Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Meghan J, O'Melia"'
Autor:
Lance L Munn, Mohammad R Nikmaneshi, Laurel B Darragh, Sana D Karam, Pinji Lei, Hengbo Zhou, Meghan J O’Melia, James W Baish, Lutz Menzel, Johanna J Rajotte, Mohammad S Razavi Rizi, Matthew G Vander Heiden, Timothy P Padera
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/c6e1acbf087946179d227bb69b62a486
Autor:
Jihoon Kim, David M. Francis, Lauren F. Sestito, Paul A. Archer, Margaret P. Manspeaker, Meghan J. O’Melia, Susan N. Thomas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Nitric oxide exerts a multitude of physiological functions and has also been exploited for anticancer therapies. Here the authors report the design of a micelle-releasing thermosensitive hydrogel system for the concomitant locoregional and lymphatic
Externí odkaz:
https://doaj.org/article/955df8be82f34fec86bf0913efa76330
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Tumor-draining lymph nodes (TdLNs) are critical in the regulation of local and systemic antitumor T cell immunity and are implicated in coordinating responses to immunomodulatory therapies.Methods Biomaterial nanoparticles that deliver che
Externí odkaz:
https://doaj.org/article/3fa5f1ebad2d4f6a9079cdc62f66252e
Publikováno v:
iScience, Vol 22, Iss , Pp 28-43 (2019)
Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here we review the functional role of lymphatic transport and lymph no
Externí odkaz:
https://doaj.org/article/30300c4056f640c083bd303d3f2835bb
Autor:
Katherine G. Birmingham, Meghan J. O'Melia, Samantha Bordy, David Reyes Aguilar, Bassel El-Reyas, Gregory Lesinski, Susan N. Thomas
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101751- (2020)
Summary: A lymph node sinus-on-a-chip adhesion microfluidic platform that recapitulates the hydrodynamic microenvironment of the lymph node subcapsular sinus was engineered. This device was used to interrogate the effects of lymph node remodeling on
Externí odkaz:
https://doaj.org/article/0d1706a2b93d47d7af57dd64d649ac94
Publikováno v:
Tissue engineering. Part A. 28(17-18)
Angiogenic and lymphangiogenic remodeling has long been accepted as a hallmark of cancer development and progression; however, the impacts of this remodeling on immunological responses, which are paramount to the responses to immunotherapeutic treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93e38072433bbdb48b86c36a11839e1
https://pubmed.ncbi.nlm.nih.gov/35442085
https://pubmed.ncbi.nlm.nih.gov/35442085
Autor:
Zhou Yuan, Meghan J. O’Melia, Kaitao Li, Jintian Lyu, Fangyuan Zhou, Prithiviraj Jothikumar, Nathan A. Rohner, Margaret P. Manspeaker, David M. Francis, Ke Bai, Chenghao Ge, Muaz N. Rushdi, Loice Chingozha, Samuel Ruipérez-Campillo, Hang Lu, Susan N. Thomas, Cheng Zhu
CD8+ T cells underpin effective anti-tumor immune responses in melanoma; however, their functions are attenuated due to various immunosuppressive factors in the tumor microenvironment (TME), resulting in disease progression. T cell function is elicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20242a410dc224aa202a531c3cfc6c8b
https://doi.org/10.1101/2022.09.11.507496
https://doi.org/10.1101/2022.09.11.507496
Autor:
Pin-Ji Lei, Ethel Pereira, Patrik Andersson, Zohreh Amoozgar, Jan Willem Van Wijnbergen, Meghan J. O'Melia, Hengbo Zhou, Sampurna Chatterjee, William Wee Ho, Jessica M. Posada, Ashwin Srinivasan Kumar, Satoru Morita, Charlie Chuang, Ilgin Ergin, Dennis Jones, Peigen Huang, Semir Beyaz, Timothy P. Padera
Publikováno v:
Cancer Research. 83:1298-1298
Tumor-draining lymph nodes are critical sites for generating tumor antigen-specific T cells and are associated with durable immune responses. However, lymph nodes are often the first site of metastasis and lymph node metastases portend worse outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab8b0102b66bf42d0eb741d604739f28
https://doi.org/10.1158/1538-7445.am2023-1298
https://doi.org/10.1158/1538-7445.am2023-1298
Publikováno v:
Cancer Immunol Immunother
Triple negative breast cancer (TNBC) is a significant clinical problem to which immunotherapeutic strategies have been applied with limited success. Using the syngeneic E0771 TNBC mouse model, this work explores the potential for anti-tumor CD8(+) T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9c7085b4816e986faae24ec8ed7979
https://doi.org/10.1007/s00262-020-02792-5
https://doi.org/10.1007/s00262-020-02792-5
Autor:
Meghan J. O'Melia, Adriana Mulero‐Russe, Jihoon Kim, Alyssa Pybus, Deborah DeRyckere, Levi Wood, Douglas K. Graham, Edward Botchwey, Andrés J. García, Susan N. Thomas
Publikováno v:
Adv Mater
Immunotherapy has emerged as one of the most powerful anti-cancer therapy classes but is stymied by the limits of existing preclinical models with respect to disease latency and reproducibility. In addition, the influence of differing immune microenv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3193f436be11d27feb5632dd9c1e5df
https://europepmc.org/articles/PMC8917077/
https://europepmc.org/articles/PMC8917077/