Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Meghan Holdorf"'
Autor:
Anastasia Hyrina, Christopher Jones, Darlene Chen, Scott Clarkson, Nadire Cochran, Paul Feucht, Gregory Hoffman, Alicia Lindeman, Carsten Russ, Frederic Sigoillot, Tiffany Tsang, Kyoko Uehara, Lili Xie, Don Ganem, Meghan Holdorf
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 2970-2978.e6 (2019)
Summary: A hallmark of chronic hepatitis B (CHB) virus infection is the presence of high circulating levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles. Although rare, sustained HBsAg loss is the idealized endpoint of any CHB t
Externí odkaz:
https://doaj.org/article/1de14fd71bb445e89c5fdea311bfc65e
Autor:
Carolina Arias, Ben Weisburd, Noam Stern-Ginossar, Alexandre Mercier, Alexis S Madrid, Priya Bellare, Meghan Holdorf, Jonathan S Weissman, Don Ganem
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003847 (2014)
Productive herpesvirus infection requires a profound, time-controlled remodeling of the viral transcriptome and proteome. To gain insights into the genomic architecture and gene expression control in Kaposi's sarcoma-associated herpesvirus (KSHV), we
Externí odkaz:
https://doaj.org/article/896446cc52d64ac0aa2ac2dac5b932a5
Autor:
Shahed Iqbal, Ruidong Li, Silpa Suthram, Jeffrey Wallin, James Trevaskis, Anastasia Hyrina, Simon Fletcher, Meghan Holdorf
Publikováno v:
Journal of Hepatology. 77:S276
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5215bfd648177ffedb90692e6aa6d1a0
https://doi.org/10.1016/s0168-8278(22)00921-7
https://doi.org/10.1016/s0168-8278(22)00921-7
Phenotypic Screen Leads to Identification of Novel Post-transcriptional Regulation Machinery for HBV
Autor:
Hassan Javanbakht, Meghan Holdorf
Publikováno v:
Phenotypic Drug Discovery ISBN: 9781788018760
Antiviral drug discovery aims to identify novel agents that inhibit viral replication or reduce expression of key pathogenic viral proteins while minimizing adverse effects. Target-based screening has been employed extensively to identify compounds t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa7070c15ca9a962dd718a58127e8731
https://doi.org/10.1039/9781839160721-00233
https://doi.org/10.1039/9781839160721-00233
Autor:
Meghan Holdorf, Nadire Cochran, Lili Xie, Paul Feucht, Scott Clarkson, Kyoko Uehara, Gregory R. Hoffman, Darlene Chen, Don Ganem, Frederic Sigoillot, Carsten Russ, Anastasia Hyrina, Alicia Lindeman, Christopher T. Jones
GRAPHICAL ABSTRACTSUMMARYA hallmark of chronic hepatitis B virus (CHB) infection is the presence of high circulating levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles. Although rare, sustained HBsAg loss is the idealized endpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260bc9cfe9475b4cb2496f1e7d32b1ec
Hepatitis E virus (HEV) is a 7.2 kb positive-sense, single-stranded RNA virus containing three partially overlapping reading frames, ORF 1-3. All non-structural proteins required for viral replication are encoded by ORF1 and are transcribed as a sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cfd969577df7be106236a950a1cff3
https://europepmc.org/articles/PMC6580954/
https://europepmc.org/articles/PMC6580954/
Autor:
Tobias Flecken, Meghan Holdorf, Marie-Anne Meier, Stefan Wieland, Peter Skewes-Cox, Markus H. Heim, David T. Barkan
Publikováno v:
Journal of Virology. 93
Covalently closed circular DNA (cccDNA) forms the basis for replication and persistence of hepatitis B virus (HBV) in the chronically infected liver. We have previously shown that viral transcription is subject to regulation by posttranslational modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d5bdb8952a0ca00fa0143d75f65a65
https://doi.org/10.1128/jvi.02036-18
https://doi.org/10.1128/jvi.02036-18
Autor:
Frederic Sigoillot, Lili Xie, Don Ganem, Kyoko Uehara, Scott Clarkson, Carsten Russ, Nadire Cochran, Tiffany Tsang, Gregory R. Hoffman, Darlene Chen, Meghan Holdorf, Paul Feucht, Anastasia Hyrina, Christopher T. Jones, Alicia Lindeman
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 2970-2978.e6 (2019)
Summary: A hallmark of chronic hepatitis B (CHB) virus infection is the presence of high circulating levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles. Although rare, sustained HBsAg loss is the idealized endpoint of any CHB t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437c578ad7f817c270632ea67c9e190a
https://pubmed.ncbi.nlm.nih.gov/31801065
https://pubmed.ncbi.nlm.nih.gov/31801065
Autor:
Amanda Goodsell, Ugur Halac, Joyce Judge, Jody L. Baron, Lia Avanesyan, Keith Mansfield, Stewart Cooper, Eric Pai, Michael Croft, Philip J. Rosenthal, Stephen L. Nishimura, Meghan Holdorf, Adil E. Wakil, Arya Koshti, Jillian M. Jespersen, Jean Publicover, Audra J. Johnson, Anuj Gaggar
Publikováno v:
Science translational medicine, vol 10, iss 433
Depending on age of acquisition, hepatitis B virus (HBV) can induce a cell-mediated immune response that results in either cure or progressive liver injury. In adult-acquired infection, HBV antigens are usually cleared, whereas in infancy-acquired in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06dd19afebfcd1e9dce2e4b81281f37
https://pubmed.ncbi.nlm.nih.gov/29622809
https://pubmed.ncbi.nlm.nih.gov/29622809
Publikováno v:
Journal of Virology. 88:6762-6777
Latency-associated nuclear antigen (LANA), a multifunctional protein expressed by the Kaposi sarcoma-associated herpesvirus (KSHV) in latently infected cells, is required for stable maintenance of the viral episome. This is mediated by two interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfe577e1071017fe5828e309c2024d6
https://doi.org/10.1128/jvi.00268-14
https://doi.org/10.1128/jvi.00268-14