Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Meghan G. Hart"'
Autor:
Christine D. Palmer, Ciaran D. Scallan, Lauren D. Kraemer Tardif, Melissa A. Kachura, Amy R. Rappaport, Daniel O. Koralek, Alison Uriel, Leonid Gitlin, Joshua Klein, Matthew J. Davis, Harshni Venkatraman, Meghan G. Hart, Jason R. Jaroslavsky, Sonia Kounlavouth, Martina Marrali, Charmaine N. Nganje, Kyounghwa Bae, Tiffany Yan, Katharyn Leodones, Milana Egorova, Sue-Jean Hong, Jenchun Kuan, Silvia Grappi, Pedro Garbes, Karin Jooss, Andrew Ustianowski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract SARS-CoV-2 has resulted in high levels of morbidity and mortality world-wide, and severe complications can occur in older populations. Humoral immunity induced by authorized vaccines wanes within 6 months, and frequent boosts may only offer
Externí odkaz:
https://doaj.org/article/a5bd0b01360c4ba2becb6b71a325f706
Autor:
Christine D. Palmer, Meghan G. Hart, Sonia Kounlavouth, Harshni Venkatraman, Lauren D. Kraemer, Martina Marrali, Calixto Dominguez, Fatema Z. Chowdhury, Jason R. Jaroslavsky, Lindsey Arcebuche, Lorenzo Hernandez, Bukola Adeoye, Severino Cuison, Amy R. Rappaport, Greg Boucher, Monica Lane, Melissa Rotunno, Kenneth Avocetien, Leiliane Sousa, Chris Puccia, Molly Likes, Rahul Vegesna, Rita Zhou, Alexis Mantilla, Matthew J. Davis, Ankur Dhanik, Melissa Johnson, Andrew R. Ferguson, Karin Jooss
Publikováno v:
Cancer Research. 83:2267-2267
Mutations in the KRAS gene are among the most common driver mutations in cancer. Targeting KRAS G12C mutations has shown some promise in clinical studies, though acquired resistance mutations pose a challenge for small molecule-based monotherapies. V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93ad16672aa616f9fe27fb240af508cd
https://doi.org/10.1158/1538-7445.am2023-2267
https://doi.org/10.1158/1538-7445.am2023-2267
Autor:
Christine D. Palmer, Amy R. Rappaport, Meghan G. Hart, Lauren D. Kraemer, Sonia Kounlavouth, Martina Marrali, Jason R. Jaroslavsky, Charmaine N. Nganje, Annie Shen, Gregory R. Boucher, Melissa A. Kachura, Ciaran D. Scallan, Sue-Jean Hong, Leonid Gitlin, Alexander I. Spira, Chrisann Kyi, Daniel V. Catenacci, Raphael Rousseau, Andrew Ferguson, Karin Jooss
Publikováno v:
Cancer Research. 82:4159-4159
The immunogenicity and efficacy of RNA-based vaccine platforms has been abundantly shown through their application in prophylactic SARS-CoV2 vaccines. Contrasting to mRNA based vectors, self amplifying mRNA platforms may offer dose-sparing and superi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62de1f445a85e4d28233716e3e9c26b2
https://doi.org/10.1158/1538-7445.am2022-4159
https://doi.org/10.1158/1538-7445.am2022-4159
Autor:
Amy R. Rappaport, Christine D. Palmer, Annie Shen, Claudia X. Dominguez, Meghan G. Hart, Lauren D. Kraemer, Sonia Koulavouth, Martina Marrali, Jason R. Jaroslavsky, Charmaine N. Nganje, Ciaran D. Scallan, Sue-Jean Hong, Leonid Gitlin, Monica Lane, Daniel V. Catenacci, Chrisann Kyi, David P. Carbone, Hossein Borghaei, Raphael Rousseau, Andrew Ferguson, Karin Jooss
Publikováno v:
Cancer Research. 82:3578-3578
Vaccines targeting neoantigens identified from common tumor driver mutations are of increasing interest as evidence of clinical benefit builds, and opportunities to combine such vaccines with immune modulators are growing. Our individualized neoantig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78232c5a27e1751e18dcb2e80be1b942
https://doi.org/10.1158/1538-7445.am2022-3578
https://doi.org/10.1158/1538-7445.am2022-3578
Autor:
Naiyer A. Rizvi, Thomas Boucher, Elie Fadel, Christine D. Palmer, Andrew Clark, Matthew J. Davis, Vladimir Makarov, John Hrom, Mark G. Frattini, Niki Karachaliou, Timothy A. Chan, Michele Busby, Kamilah Caldwell, Mojca Skoberne, Jennifer Busby, Karin Choquette, Ian Anderson, Joshua M. Francis, Jesse Abhyankar, Meghan G. Hart, Vincent Thomas de Montpréville, Olaf Mercier, Raphael Rousseau, Karin Jooss, Paolo Bironzo, Aaron Yang, Alexander I. Spira, Rafael Rosell, Tyler Murphy, Fujiko Duke, Roman Yelensky, Noelle C Ojo, Lauren Young, Chainarong Limvarapuss, Giorgio V. Scagliotti, Nashat Gabrail, Brendan Bulik-Sullivan, Cynthia Voong, Silvia Novello
Publikováno v:
Nature biotechnology.
Neoantigens, which are expressed on tumor cells, are one of the main targets of an effective antitumor T-cell response. Cancer immunotherapies to target neoantigens are of growing interest and are in early human trials, but methods to identify neoant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2895fb09c854c605a8f4ae6a758fcc
https://pubmed.ncbi.nlm.nih.gov/30556813
https://pubmed.ncbi.nlm.nih.gov/30556813
Autor:
Alexandra Massa, Holly L. Everett, Jonathan Richard, Andrés Finzi, Meghan G. Hart, Gordon J. Freeman, Daniel E. Kaufmann, Nathalie Brassard, Maxime Veillette, Muska Hassan, Jean-Pierre Routy, Ngoc L. Ly, Filippos Porichis, Mathieu Dubé, Antigoni Morou
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 201(3)
Immune exhaustion is an important feature of chronic infections, such as HIV, and a barrier to effective immunity against cancer. This dysfunction is in part controlled by inhibitory immune checkpoints. Blockade of the PD-1 or IL-10 pathways can rein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a894c69b075e535af1bf4fc764a5fd
https://pubmed.ncbi.nlm.nih.gov/29934472
https://pubmed.ncbi.nlm.nih.gov/29934472
Autor:
Mojca Skoberne, Raphael Rousseau, Jennifer Busby, Brendan Bulik, Naiyer A. Rizvi, Karin Jooss, Aaron Yang, Mark Frattini, Joshua M. Francis, Rita Zhou, Matthew M. Davis, Meghan G. Hart, Cynthia Voong, Andrew Clark, Lauren Young, Kamilah Caldwell, Tyler Murphy, Fujiko Duke, Roman Yelensky, Mike Zhong, Jesse Abhyankar, Christine D. Palmer, Alison Cook, Thomas Boucher
Publikováno v:
Cancer Research. 79:4059-4059
Immune Checkpoint Blockade (ICB) has revolutionized the treatment of patients with cancer but provides durable clinical benefit to only a minority of patients. Neoantigens, antigens derived from tumor mutations, are emerging as key targets of T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ac3488283de14322288b70f416255c2
https://doi.org/10.1158/1538-7445.am2019-4059
https://doi.org/10.1158/1538-7445.am2019-4059
Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women
Autor:
Heike Hildebrandt, Jean-Philippe Herbeuval, Susanne Ziegler, Claudia Beisel, Marcus Altfeld, Sophie Laffont, Michael Sirignano, Brigitte Autran, Nikaïa Smith, Jean-Charles Guéry, Armon Sharei, Sylvie Le Gall, Lise Chauveau, Meghan G. Hart, Olivier Schwartz, Thomas J. Diefenbach, Phillip Tomezsko, Georgio Kourjian, Filippos Porichis, Christine D. Palmer, Morgane Griesbeck, J. Judy Chang, Alexandra-Chloé Villani, Claire Cenac
Publikováno v:
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2015, 195 (11), pp.5327-36. ⟨10.4049/jimmunol.1501684⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2015, 195 (11), pp.5327-36. 〈10.4049/jimmunol.1501684〉
Journal of Immunology, 2015, 195 (11), pp.5327-36. ⟨10.4049/jimmunol.1501684⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2015, 195 (11), pp.5327-36. ⟨10.4049/jimmunol.1501684⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2015, 195 (11), pp.5327-36. 〈10.4049/jimmunol.1501684〉
Journal of Immunology, 2015, 195 (11), pp.5327-36. ⟨10.4049/jimmunol.1501684⟩
Increased IFN-α production contributes to the pathogenesis of infectious and autoimmune diseases. Plasmacytoid dendritic cells (pDCs) from females produce more IFN-α upon TLR7 stimulation than pDCs from males, yet the mechanisms underlying this dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2a66918d07dc0b258ced614dc38dc2
https://hal-pasteur.archives-ouvertes.fr/pasteur-01372393
https://hal-pasteur.archives-ouvertes.fr/pasteur-01372393
Autor:
Amy E. Baxter, Holly L. Everett, Madelene Lindqvist, Muska Hassan, Susan Reynolds, Filippos Porichis, Scott Mordecai, Brett Norris, Morgane Griesbeck, Chunfai Lai, Sara M. Miller, Daniel G. Kavanagh, Damien Z. Soghoian, Daniel Kaufmann, Quan Nguyen, Meghan G. Hart
Publikováno v:
Nature communications
Fluorescent in situ hybridization (FISH) is a method that uses fluorescent probes to detect specific nucleic acid sequences at the single-cell level. Here we describe optimized protocols that exploit a highly sensitive FISH method based on branched D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea11c09a749c82c4f88c44767965523
https://doi.org/10.1038/ncomms6641
https://doi.org/10.1038/ncomms6641
Autor:
Jennifer Zupkosky, Lucie Barblu, Meghan G. Hart, Gordon J. Freeman, Daniel Kaufmann, Thomas J. Brennan, Rafi Ahmed, Ashley McMullen, Douglas S. Kwon, Filippos Porichis, Daniel G. Kavanagh
Publikováno v:
Journal of virology. 88(5)
Antigen persistence in chronic infections and cancer upregulates inhibitory networks, such as the PD-1 and interleukin-10 (IL-10) pathways, that impair immunity and lead to disease progression. These pathways are attractive targets for immunotherapy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cfff7abf254e7bd1a7bd3d3c69d6591
https://pubmed.ncbi.nlm.nih.gov/24352453
https://pubmed.ncbi.nlm.nih.gov/24352453