Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Meghan E. Wynne"'
Autor:
Thomas S. Wingo, Yue Liu, Ekaterina S. Gerasimov, Selina M. Vattathil, Meghan E. Wynne, Jiaqi Liu, Adriana Lori, Victor Faundez, David A. Bennett, Nicholas T. Seyfried, Allan I. Levey, Aliza P. Wingo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Studying the shared genetic etiology of disease can help improve diagnosis and treatment. Here, the authors find evidence for shared genetic and molecular pathophysiology between several common psychiatric and neurodegenerative diseases using results
Externí odkaz:
https://doaj.org/article/b0d7b7da35414544b542e983ada6206d
Autor:
Meghan E Wynne, Oluwaseun Ogunbona, Alicia R Lane, Avanti Gokhale, Stephanie A Zlatic, Chongchong Xu, Zhexing Wen, Duc M Duong, Sruti Rayaprolu, Anna Ivanova, Eric A Ortlund, Eric B Dammer, Nicholas T Seyfried, Blaine R Roberts, Amanda Crocker, Vinit Shanbhag, Michael Petris, Nanami Senoo, Selvaraju Kandasamy, Steven Michael Claypool, Antoni Barrientos, Aliza Wingo, Thomas S Wingo, Srikant Rangaraju, Allan I Levey, Erica Werner, Victor Faundez
Publikováno v:
eLife, Vol 12 (2023)
Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors. Here, we demonstrate that mitochondrial regulation of the secretome is more extensive tha
Externí odkaz:
https://doaj.org/article/f59364e09ba749e59bd95488824ad15b
Autor:
Meghan E Wynne, Oluwaseun Ogunbona, Alicia R Lane, Avanti Gokhale, Stephanie A Zlatic, Chongchong Xu, Zhexing Wen, Duc M Duong, Sruti Rayaprolu, Anna Ivanova, Eric A Ortlund, Eric B Dammer, Nicholas T Seyfried, Blaine R Roberts, Amanda Crocker, Vinit Shanbhag, Michael Petris, Nanami Senoo, Selvaraju Kandasamy, Steven Michael Claypool, Antoni Barrientos, Aliza Wingo, Thomas S Wingo, Srikant Rangaraju, Allan I Levey, Erica Werner, Victor Faundez
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0581dc23c9240a230b1ea4bcd4158336
https://doi.org/10.7554/elife.85779.sa2
https://doi.org/10.7554/elife.85779.sa2
Autor:
Erica Werner, David A. Lewis, Carrie E. Bearden, Meghan E. Wynne, Nicholas T. Seyfried, Zhexing Wen, Nicole Shearing, Oluwaseun B. Ogunbona, Avanti Gokhale, Julia L. Bassell, Duc M. Duong, Jill R. Glausier, Matthew J. M. Rowan, Chongchong Xu, Viktor János Oláh, Amanda A. H. Freeman, Chelsea E. Lee, Stephanie A. Zlatic, Cortnie Hartwig, Victor Faundez
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 41, iss 31
J Neurosci
J Neurosci
Eukaryotic cells maintain proteostasis through mechanisms that require cytoplasmic and mitochondrial translation. Genetic defects affecting cytoplasmic translation perturb synapse development, neurotransmission, and are causative of neurodevelopmenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddc35451c70ec74bb2ad9520ec41bbb
https://doi.org/10.1523/jneurosci.2197-20.2021
https://doi.org/10.1523/jneurosci.2197-20.2021
Autor:
Meghan E Wynne, Oluwaseun Ogunbona, Alicia R Lane, Avanti Gokhale, Stephanie A Zlatic, Chongchong Xu, Zhexing Wen, Duc M Duong, Sruti Rayaprolu, Anna Ivanova, Eric A Ortlund, Eric B Dammer, Nicholas T Seyfried, Blaine R Roberts, Amanda Crocker, Vinit Shanbhag, Michael Petris, Nanami Senoo, Selvaraju Kandasamy, Steven Michael Claypool, Antoni Barrientos, Aliza Wingo, Thomas S Wingo, Srikant Rangaraju, Allan I Levey, Erica Werner, Victor Faundez
Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors. Here, we demonstrate that mitochondrial regulation of the secretome is more extensive tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65329a4d8e687b2d4fa59e0ef7527fcc
https://doi.org/10.1101/2022.05.11.491499
https://doi.org/10.1101/2022.05.11.491499
Autor:
Thomas S, Wingo, Yue, Liu, Ekaterina S, Gerasimov, Selina M, Vattathil, Meghan E, Wynne, Jiaqi, Liu, Adriana, Lori, Victor, Faundez, David A, Bennett, Nicholas T, Seyfried, Allan I, Levey, Aliza P, Wingo
Publikováno v:
Nature communications. 13(1)
Several common psychiatric and neurodegenerative diseases share epidemiologic risk; however, whether they share pathophysiology is unclear and is the focus of our investigation. Using 25 GWAS results and LD score regression, we find eight significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f9436c55cac08e0fc9e92116a634dbf
https://pubmed.ncbi.nlm.nih.gov/35882878
https://pubmed.ncbi.nlm.nih.gov/35882878
Autor:
Kaela S. Singleton, Jennifer Q. Kwong, Amanda Crocker, Avanti Gokhale, Victor Faundez, Alicia R. Lane, Duc M. Duong, Meghan E. Wynne, Stephanie A. Zlatic, Erica Werner
Publikováno v:
eNeuro
Mitochondrial composition varies by organ and their constituent cell types. This mitochondrial diversity likely determines variations in mitochondrial function. However, the heterogeneity of mitochondria in the brain remains underexplored despite the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf55041e07385d4146a4a8fdb562fa8c
https://pubmed.ncbi.nlm.nih.gov/34312306
https://pubmed.ncbi.nlm.nih.gov/34312306
Autor:
Carrie E. Bearden, Erica Werner, Nicole Shearing, Cortnie Hartwig, Avanti Gokhale, Meghan E. Wynne, Zhexing Wen, David A. Lewis, Chelsea E. Lee, Oluwaseun B. Ogunbona, Julia L. Bassell, Stephanie A. Zlatic, Nicholas T. Seyfried, Jill R. Glausier, Faundez, Freeman Aah, Chongchong Xu
Eukaryotic cells maintain proteostasis through mechanisms that require cytoplasmic and mitochondrial translation. Genetic defects affecting cytoplasmic translation perturb synapse development, neurotransmission, and are causative of neurodevelopmenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0066d8e2a4e84c96b191d98fea13cd
Publikováno v:
Frontiers in Integrative Neuroscience
Frontiers in Integrative Neuroscience, Vol 13 (2019)
Frontiers in Integrative Neuroscience, Vol 13 (2019)
Neurodevelopmental disorders represent a challenging biological and medical problem due to their genetic and phenotypic complexity. In many cases, we lack the comprehensive understanding of disease mechanisms necessary for targeted therapeutic develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc972e1701450b7047597dbf2ea195c
https://pubmed.ncbi.nlm.nih.gov/31379529
https://pubmed.ncbi.nlm.nih.gov/31379529