Výsledky vyhledávání - "Meghan E. Kerrisk"

ECM receptors in neuronal structure, synaptic plasticity, and behavior

Autor: Lorenzo A. Cingolani, Meghan E. Kerrisk, Anthony J. Koleske

During central nervous system development, extracellular matrix (ECM) receptors and their ligands play key roles as guidance molecules, informing neurons where and when to send axonal and dendritic projections, establish connections, and form synapse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe339440cb6adfe99f1d8d9ca76949ef
https://europepmc.org/articles/PMC4640673/

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Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

Autor: Adam C. Kaufman, Jacqueline K. Heiss, Meghan E. Kerrisk, Stephen M. Strittmatter, Mikhail A. Kostylev, Anthony J. Koleske, Erik C. Gunther, Thomas Wisniewski, Massimiliano Stagi, Alexander O. Vortmeyer, Hideyuki Takahashi, Ji Won Um, Haakon B. Nygaard

Publikováno v: Neuron. 80(2)

Soluble amyloid-β oligomers (Aβo) trigger Alzheimer's disease (AD) pathophysiology and bind with high affinity to cellular prion protein (PrP(C)). At the postsynaptic density (PSD), extracellular Aβo bound to lipid-anchored PrP(C) activates intrac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3463072bf51aad947d1860772ea73b

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Arg Kinase Signaling in Dendrite and Synapse Stabilization Pathways: Memory, Cocaine Sensitivity, and Stress

Autor: Anthony J. Koleske, Meghan E. Kerrisk

The Abl2/Arg nonreceptor tyrosine kinase is enriched in dendritic spines where it is essential for maintaining dendrite and synapse stability in the postnatal mouse brain. Arg is activated downstream of integrin α3β1 receptors and it regulates the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e2a140aed8433b5719afba3758ebf2
https://europepmc.org/articles/PMC3797846/

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Integrin α3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behavior

Autor: Anthony J. Koleske, Charles A. Greer, Meghan E. Kerrisk

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(16)

Most dendrite branches and a large fraction of dendritic spines in the adult rodent forebrain are stable for extended periods of time. Destabilization of these structures compromises brain function and is a major contributing factor to psychiatric an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0990a17a374d037426d5045fc64de8a8
https://pubmed.ncbi.nlm.nih.gov/23595732

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