Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Meghan E. Hopf"'
Autor:
Sheila R. Costford, Bram Brouwers, Meghan E. Hopf, Lauren M. Sparks, Mauro Dispagna, Ana P. Gomes, Heather H. Cornnell, Chris Petucci, Peter Phelan, Hui Xie, Fanchao Yi, Glenn A. Walter, Timothy F. Osborne, David A. Sinclair, Randall L. Mynatt, Julio E. Ayala, Stephen J. Gardell, Steven R. Smith
Publikováno v:
Molecular Metabolism, Vol 7, Iss , Pp 1-11 (2018)
Objective: Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD+), an essential co-substrate regulating a myriad of signaling pathways. We produced a m
Externí odkaz:
https://doaj.org/article/cefef0c499e9466090c8b56c7f367887
Autor:
Bram Brouwers, Natalie A. Stephens, Sheila R. Costford, Meghan E. Hopf, Julio E. Ayala, Fanchao Yi, Hui Xie, Jian-Liang Li, Stephen J. Gardell, Lauren M. Sparks, Steven R. Smith
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Mice overexpressing NAMPT in skeletal muscle (NamptTg mice) develop higher exercise endurance and maximal aerobic capacity (VO2max) following voluntary exercise training compared to wild-type (WT) mice. Here, we aimed to investigate the mechanisms un
Externí odkaz:
https://doaj.org/article/9ec1bf409ca84269ba312c2f1542ef6d
Autor:
Timothy F. Osborne, Joshua S Smith, Adeline Divoux, Dóra Bojcsuk, Fanchao Yi, Balint L. Balint, Katalin Sandor, Meghan E. Hopf, Steven R. Smith
Publikováno v:
Journal of the Endocrine Society
Background Preferential accumulation of fat in the upper body (apple shape) is associated with higher risk of developing metabolic syndrome relative to lower body fat (pear shape). We previously discovered that chromatin openness partially defined th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd76104a355c72b2c5348291b2fa73e
https://doi.org/10.1210/jendso/bvaa042
https://doi.org/10.1210/jendso/bvaa042
Autor:
Randall L. Mynatt, Sheila R. Costford, Stephen J. Gardell, Bram Brouwers, David A. Sinclair, Lauren M. Sparks, Heather H. Cornnell, Julio E. Ayala, Hui Xie, Meghan E. Hopf, Fanchao Yi, Glenn A. Walter, Steven R. Smith, Timothy F. Osborne, Chris Petucci, Mauro Dispagna, Peter E. Phelan, Ana P. Gomes
Publikováno v:
Molecular Metabolism, Vol 7, Iss, Pp 1-11 (2018)
Molecular Metabolism
Molecular Metabolism
Objective Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD+), an essential co-substrate regulating a myriad of signaling pathways. We produced a mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89a01374700cb489521f89013a4e5f9
https://doi.org/10.1016/j.molmet.2017.10.012
https://doi.org/10.1016/j.molmet.2017.10.012
Autor:
Mayuko Akiu, Steven E. Cohen, Chen-Ting Ma, E. Hampton Sessions, Layton H. Smith, Michael R. Jackson, Paul Hershberger, Stephen J. Gardell, Patrick R. Maloney, Takashi Tsuji, Eduard Sergienko, Satyamaheshwar Peddibhotla, Jun Tanaka, Anthony B. Pinkerton, Tsuyoshi Nakamura, Meghan E. Hopf
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 41:128007
NAD+ is a crucial cellular factor that plays multifaceted roles in wide ranging biological processes. Low levels of NAD+ have been linked to numerous diseases including metabolic disorders, cardiovascular disease, neurodegeneration, and muscle wastin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e4dbfbf4d7a8be49608d581c3278b1
https://doi.org/10.1016/j.bmcl.2021.128007
https://doi.org/10.1016/j.bmcl.2021.128007
Autor:
Jun Tanaka, Emmanuel S. Burgos, Rebecca Falter, E. Hampton Sessions, Jeanne Brooks, Stephen J. Gardell, Steven E. Cohen, Anthony B. Pinkerton, Asima Khan, Jennifer S. Hirschi, Meghan E. Hopf, Nidhi Kapoor, Jeffrey A. Culver, Chris Petucci, Steven R. Smith, Eduard Sergienko, Chen Ting Ma, Mauro Dispagna
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Pharmacological strategies that boost intracellular NAD+ are highly coveted for their therapeutic potential. One approach is activation of nicotinamide phosphoribosyltransferase (NAMPT) to increase production of nicotinamide mononucleotide (NMN), the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585eec1c791ac237c67f377064693612
https://doi.org/10.1038/s41467-019-11078-z
https://doi.org/10.1038/s41467-019-11078-z
Autor:
Natalie A. Stephens, Meghan E. Hopf, Sheila R. Costford, Jian-Liang Li, Lauren M. Sparks, Steven R. Smith, Hui Xie, Stephen J. Gardell, Julio E. Ayala, Bram Brouwers, Fanchao Yi
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Frontiers in Physiology
Frontiers in Physiology
Mice overexpressing NAMPT in skeletal muscle (NamptTg mice) develop higher exercise endurance and maximal aerobic capacity (VO2max) following voluntary exercise training compared to wild-type (WT) mice. Here, we aimed to investigate the mechanisms un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99fa05cbd7d7aa5ce9a4e9abc01d93a
https://www.frontiersin.org/article/10.3389/fphys.2018.00704/full
https://www.frontiersin.org/article/10.3389/fphys.2018.00704/full