Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Meghan E. Bushway"'
Autor:
Mark M. Awad, Ramaswamy Govindan, Kristen N. Balogh, David R. Spigel, Edward B. Garon, Meghan E. Bushway, Asaf Poran, Joong Hyuk Sheen, Victoria Kohler, Ekaterina Esaulova, John Srouji, Suchitra Ramesh, Rohit Vyasamneni, Binisha Karki, Tracey E. Sciuto, Himanshu Sethi, Jesse Z. Dong, Melissa A. Moles, Kelledy Manson, Michael S. Rooney, Zakaria S. Khondker, Mark DeMario, Richard B. Gaynor, Lakshmi Srinivasan
Publikováno v:
Cancer cell. 40(9)
Neoantigens arising from mutations in tumor DNA provide targets for immune-based therapy. Here, we report the clinical and immune data from a Phase Ib clinical trial of a personalized neoantigen-vaccine NEO-PV-01 in combination with pemetrexed, carbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935d29553f74594992b9744ac0684da4
https://pubmed.ncbi.nlm.nih.gov/36027917
https://pubmed.ncbi.nlm.nih.gov/36027917
Autor:
Rohit Vyasamneni, Victoria Kohler, Binisha Karki, Gauri Mahimkar, Ekaterina Esaulova, Jonathan McGee, Daniel Kallin, Joong Hyuk Sheen, Dewi Harjanto, Miles Kirsch, Asaf Poran, Jesse Dong, Lakshmi Srinivasan, Richard B. Gaynor, Meghan E. Bushway, John R. Srouji
Publikováno v:
Cell Reports Methods. 3:100388
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50694cbe8d76c8b0748573cdf16279f3
https://doi.org/10.1016/j.crmeth.2022.100388
https://doi.org/10.1016/j.crmeth.2022.100388
Autor:
Meghan E. Bushway, Melissa A. Moles, Amy Wanamaker, Zakaria S. Khondker, Mark DeMario, David R. Spigel, Jennifer Tepper, Mark Awad, Ramaswamy Govindan, Saiama N. Waqar, Kristen N. Balogh, Asaf Poran, Richard B. Gaynor, Edward B. Garon, Jesse Z. Dong, Aaron Lisberg, Lakshmi Srinivasan, April Lamb, John Srouji
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Neoantigens arising from mutations in cancer cell DNA are important targets for T cell mediated anti-tumor immunity. NEO-PV-01 is a personal neoantigen vaccine of up to 20 peptides (14–35 amino acids) based on a patient‘s HLA profile a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c2b26d52ca49422c84c0b2a2796bf4
https://doaj.org/article/87f0b6347d22484b87bc7e8bf04d1d1e
https://doaj.org/article/87f0b6347d22484b87bc7e8bf04d1d1e
Autor:
Meghan E. Bushway, Kristen N. Balogh, Lakshmi Srinivasan, Zakaria S. Khondker, Patrick A. Ott, Rana H. Besada, Richard B. Gaynor, Julian Scherer, Jasmina Prabhakara, Siwen Hu-Lieskovan, Michael S. Rooney, Reid G. Williams, Amy Wanamaker, Asaf Poran
Publikováno v:
Cell Reports Medicine
Summary T cells use highly diverse receptors (TCRs) to identify tumor cells presenting neoantigens arising from genetic mutations and establish anti-tumor activity. Immunotherapy harnessing neoantigen-specific T cells to target tumors has emerged as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454be1df2b0d61360ad4496862fe793c
https://pubmed.ncbi.nlm.nih.gov/33294862
https://pubmed.ncbi.nlm.nih.gov/33294862
Autor:
Lakshmi Srinivasan, Yvonne Ware, Kelledy Manson, Asaf Poran, Benjamin Trapp, Joel Greshock, Mark M. Awad, Dominik Barthelme, Dewi Harjanto, Victoria Kohler, Ying S. Ting, Richard B. Gaynor, Yuting Huang, Matthew D. Hellmann, Samantha J. Turnbull, Siwen Hu-Lieskovan, Ed Fritsch, Meghan E. Bushway, Jessica J. Lin, Lisa D. Cleary, Bartosz Chmielowski, Zhengping Huang, Michael S. Rooney, Terence W. Friedlander, Rana H. Besada, Patrick A. Ott, Zakaria S. Khondker, Mark DeMario, Kristen N. Balogh, Aung Naing, Melissa A. Moles, Riley R. Curran, Kim Margolin, Nina Bhardwaj, Tracey E. Sciuto, Jesse Z. Dong, Ramaswamy Govindan, Julian Scherer, Amy Wanamaker
Publikováno v:
Cell. 183(2)
Summary Neoantigens arise from mutations in cancer cells and are important targets of T cell-mediated anti-tumor immunity. Here, we report the first open-label, phase Ib clinical trial of a personalized neoantigen-based vaccine, NEO-PV-01, in combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515738446c00429f62713aedbb493a4c
https://pubmed.ncbi.nlm.nih.gov/34781699
https://pubmed.ncbi.nlm.nih.gov/34781699
Autor:
Amy Wanamaker, Zakaria S. Khondkar, Victoria Kohler, Meghan E. Bushway, Mark DeMario, Rohit Vyasamneni, Edward B. Garon, David R. Spigel, Jennifer Tepper, Melissa A. Moles, Kristen N. Balogh, Lakshmi Srinivasan, Asaf Poran, John Srouji, Mark M. Awad, Tracey E. Sciuto, Ramaswamy Govindan, Suchitra Ramesh, Jesse Z. Dong, Richard B. Gaynor
Publikováno v:
Cancer Research. 81:73-73
Background: Neoantigens arising from mutations in cancer cell DNA are important targets for T cell-mediated anti-tumor immunity. NEO-PV-01 is a personal neoantigen vaccine of up to 20 peptides (14-35 amino acids) based on a patient's HLA profile and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd7af39f7b55e8dc605d911f86a4231c
https://doi.org/10.1158/1538-7445.am2021-73
https://doi.org/10.1158/1538-7445.am2021-73
Autor:
Meghan E. Bushway, Ying Sonia Ting, Rana H. Besada, Tracey E. Sciuto, Jasmina Prabhakara, Julian Scherer, Kristen N. Balogh, April Lamb, Jennifer A. Kaplan, Lisa D. Cleary, Melissa A. Moles, Sarah E. Church, Yuqi Ren, Xing Ren, Richard B. Gaynor, Matthew J. Goldstein, Les H. Brail, Joel Greshock, Lakshmi Srinivasan
Publikováno v:
Cancer Research. 79:5006-5006
Background: Neoantigens arise from DNA mutations in cancer cells and are important targets for T cell mediated anti-tumor immunity. NEO-PV-01 is a personal neoantigen vaccine of up to 20 peptides designed based on a patient’s neoantigen and HLA pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba1f53bb862c4ceef712f95cd683a6cc
https://doi.org/10.1158/1538-7445.am2019-5006
https://doi.org/10.1158/1538-7445.am2019-5006
Autor:
Riley R. Curran, Matthew J. Goldstein, Meghan E. Bushway, Kristen N. Balogh, Dewi Harjanto, April Lamb, Rana H. Besada, Tracey E. Sciuto, Joel Greshock, Samantha J. Gates, Yvonne Ware, Lisa D. Cleary, Siwen Hu-Lieskovan, Richard B. Gaynor, Michael S. Rooney, Julian Scherer, Lakshmi Srinivasan, Victoria R. Kohler, Aung Naing, Ying S. Ting, Yuting Huang, Melissa A. Moles, Zhengping Huang, Les H. Brail, Patrick A. Ott
Publikováno v:
Cancer Research. 79:942-942
Background: Neoantigens arise from DNA mutations in cancer cells and are important targets for T cell mediated anti-tumor immunity. NEO-PV-01 is a personal neoantigen vaccine of up to 20 peptides designed based on a patient’s neoantigen and HLA pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d4315c109868a4d3a7edbe89c78a01
https://doi.org/10.1158/1538-7445.am2019-942
https://doi.org/10.1158/1538-7445.am2019-942
Autor:
April Lamb, Julian Scherer, Victoria Kohler, Melissa A. Moles, Dominik Barthelme, Richard B. Gaynor, Lisa D. Cleary, Lakshmi Srinivasan, Riley R. Curran, Joel Greshock, Matthew J. Goldstein, Jose G. Martinez, Meghan E. Bushway, Samantha J. Gates, Jesse Z. Dong, Aung Naing, Patrick A. Ott
Publikováno v:
Cancer Research. 78:LB-147
Background: Neoantigens arise from DNA mutations and are critical targets that are presented on the surface of cancer cells for tumor-specific T cell responses. Vaccines targeting neoantigens have the potential to induce de novo and amplify pre-exist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fbeff9a4e790d07b819766de3af648a
https://doi.org/10.1158/1538-7445.am2018-lb-147
https://doi.org/10.1158/1538-7445.am2018-lb-147
Autor:
Meghan E, Bushway, Scott A, Gerber, Bruce M, Fenton, Richard K, Miller, Edith M, Lord, Shawn P, Murphy
Publikováno v:
Biology of reproduction. 90(5)
The human placenta performs multiple essential functions required for successful pregnancy. Alterations in the placental vasculature have been implicated in severe complications of pregnancy. Despite the importance of placental vascular function duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a40ab2b2901dbd0345b80b0fc71a9cf
https://pubmed.ncbi.nlm.nih.gov/24648400
https://pubmed.ncbi.nlm.nih.gov/24648400