Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Meghan E. Boyer"'
Autor:
Meghan E. Boyer, Emery H. Bresnick, Xin Gao, Yuan I. Chang, Colin N. Dewey, Jing Zhang, Kirby D. Johnson
Publikováno v:
The Journal of Experimental Medicine
Cis-element requirement for the emergence of HSCs in the AGM and for hemogenic endothelium to generate HSC-containing c-Kit+ cell clusters.
The generation of hematopoietic stem cells (HSCs) from hemogenic endothelium within the aorta, gonad, mes
The generation of hematopoietic stem cells (HSCs) from hemogenic endothelium within the aorta, gonad, mes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e7202d818208624fd38356a13addd8
https://doi.org/10.1084/jem.20130733
https://doi.org/10.1084/jem.20130733
Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity
Autor:
Katherine R. Calvo, Xin Gao, Youngsook Lee, Steven M. Holland, Yangang Liu, Jinyong Wang, Meghan E. Boyer, Jing Zhang, Myung-Jeom Ryu, Kirby D. Johnson, Sunduz Keles, Amy P. Hsu, Emery H. Bresnick
Publikováno v:
Journal of Clinical Investigation. 122:3692-3704
Haploinsufficiency for GATA2 causes human immunodeficiency syndromes characterized by mycobacterial infection, myelodysplasia, lymphedema, or aplastic anemia that progress to myeloid leukemia. GATA2 encodes a master regulator of hematopoiesis that is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed9324d790e1bf320acb459883a63e3
https://doi.org/10.1172/jci61623
https://doi.org/10.1172/jci61623
Publikováno v:
Journal of Biological Chemistry. 286:18834-18844
A poorly understood problem in genetics is how the three-dimensional organization of the nucleus contributes to establishment and maintenance of transcriptional networks. Genetic loci can reside in chromosome “territories” and undergo dynamic cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34ae19589d4f942f233b3c21f6ea76e
https://doi.org/10.1074/jbc.m111.221481
https://doi.org/10.1074/jbc.m111.221481
Autor:
Hsiang-Ying Lee, Emery H. Bresnick, Kirby D. Johnson, Tohru Fujiwara, Shin Il Kim, Meghan E. Boyer
Publikováno v:
Molecular Cell. 36(6):984-995
Abstract 1467 Poster Board I-490 GATA factors function via distinct modes to establish transcriptional networks that control fundamental developmental processes including hematopoiesis. Whereas the master regulator of hematopoiesis GATA-1 is subject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437a9a9fc9762447fb222103f5256074
Autor:
Sunduz Keles, Tuan M. Tran, Ken He Young, Emery H. Bresnick, Kyunghee Choi, Ryan J. Wozniak, Meghan E. Boyer, Jesse J. Lugus
Publikováno v:
Molecular and Cellular Biology. 28:6681-6694
Combinatorial interactions among trans-acting factors establish transcriptional circuits that orchestrate cellular differentiation, survival, and development. Unlike circuits instigated by individual factors, efforts to identify gene ensembles contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e170d01e28f87aea9d839de94cfbfd
https://doi.org/10.1128/mcb.01061-08
https://doi.org/10.1128/mcb.01061-08
Publikováno v:
Biochemistry. 47:859-869
Whereas the transcription factors GATA-1 and GATA-2 function both uniquely and redundantly to control blood cell development, the process termed hematopoiesis, mechanisms underlying their unique versus common functions are poorly understood. We used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aee3a3e4cc5a408afe38c5fad5d3f07
https://doi.org/10.1021/bi701692p
https://doi.org/10.1021/bi701692p
Publikováno v:
Journal of Biological Chemistry. 282:14665-14674
GATA factors are fundamental components of developmentally important transcriptional networks. By contrast to common mechanisms in which transacting factors function directly at promoters, the hematopoietic GATA factors GATA-1 and GATA-2 often assemb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bf16adef1b1fc56dc1488b16c5b22da
https://doi.org/10.1074/jbc.m700792200
https://doi.org/10.1074/jbc.m700792200
Autor:
Sean M. Hasso, Saumen Pal, Meghan E. Boyer, Timothy M. Gomez, Justin K. Murray, Michele A. Wozniak, Jing Wu, Emery H. Bresnick, Patricia J. Keely, Samuel H. Gellman, John F. Fallon
Publikováno v:
The Journal of Cell Biology
Establishment of angiogenic circuits that orchestrate blood vessel development and remodeling requires an exquisite balance between the activities of pro- and antiangiogenic factors. However, the logic that permits complex signal integration by vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae74cbf91de25eb8dbddd84dc91ce51
https://doi.org/10.1083/jcb.200603152
https://doi.org/10.1083/jcb.200603152
Publikováno v:
Journal of Biological Chemistry. 280:1724-1732
Given the simplicity of the DNA sequence that mediates binding of GATA transcription factors, GATA motifs reside throughout chromosomal DNA. However, chromatin immunoprecipitation analysis has revealed that GATA-1 discriminates exquisitely among thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2769ae2baa9bfba27bff63c7e33814
https://doi.org/10.1074/jbc.m406038200
https://doi.org/10.1074/jbc.m406038200
Disease mutations provide unique opportunities to decipher protein and cell function. Mutations in the master regulator of hematopoiesis GATA-2 underlie an immunodeficiency associated with myelodysplastic syndrome and leukemia. We discovered that a G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2a20d1671c8de6e3e99962cd702016
https://europepmc.org/articles/PMC4198037/
https://europepmc.org/articles/PMC4198037/
