Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Meghan Drummond"'
Autor:
Charleen Hunt, Suzanne A. Hartford, Derek White, Evangelos Pefanis, Timothy Hanna, Clarissa Herman, Jarrell Wiley, Heather Brown, Qi Su, Yurong Xin, Dennis Voronin, Hien Nguyen, Judith Altarejos, Keith Crosby, Jeffery Haines, Sarah Cancelarich, Meghan Drummond, Sven Moller-Tank, Ryan Malpass, Jacqueline Buckley, Maria del Pilar Molina-Portela, Gustavo Droguett, David Frendewey, Eric Chiao, Brian Zambrowicz, Guochun Gong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
CRISPR-Cas9 is a gene editing tool that can be used to modulate gene expression. Here, the authors report the generation of a mouse model that express all components of the CRISPR-Cas9 guide directed Synergistic Activation Mediator (SAM), demonstrate
Externí odkaz:
https://doaj.org/article/17fb14b41cbb4fa7890fbff2faf8ff19
Autor:
Shawn Mishra, Siying Chen, Manuel A. R. Ferreira, Brian Zambrowicz, Jeffrey Staples, Alexander Popov, Yu Bai, Arden Moscati, Alexandra Kaufman, Ariane H. Ayer, Meghan Drummond, Jonathan Marchini, Aris Baras, Janell Smith, Lauren Gurski, Kavita Praveen, Lee Dobbyn, Esteban Chen, Christian Benner, Olle Melander, Gonçalo R. Abecasis, Suganthi Balasubramanian, Marcus Herbert Jones, Giovanni Coppola, Eli A. Stahl
Understanding the genetic underpinnings of disabling hearing loss, which affects ∼466 million people worldwide, can provide avenues for new therapeutic target development. We performed a genome-wide association meta-analysis of hearing loss with 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b1ee3b60b863b0db814a04e0516815
https://doi.org/10.1101/2021.09.27.21264091
https://doi.org/10.1101/2021.09.27.21264091
Autor:
Jeffery Haines, Derek White, Maria del Pilar Molina-Portela, Brian Zambrowicz, Gustavo Droguett, Jarrell Wiley, Clarissa Herman, Timothy Hanna, Judith Altarejos, Hien Nguyen, Sven Moller-Tank, Qi Su, Heather Brown, Sarah Cancelarich, Dennis Voronin, Jacqueline Buckley, Evangelos Pefanis, Eric Chiao, Suzanne Hartford, David Frendewey, Meghan Drummond, Ryan Malpass, Keith Crosby, Charleen Hunt, Yurong Xin, Guochun Gong
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
CRISPR-based transcriptional activation is a powerful tool for functional gene interrogation; however, delivery difficulties have limited its applications in vivo. Here, we created a mouse model expressing all components of the CRISPR-Cas9 guide RNA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39debf08c4dc1f37634a7861458d9e2d
https://doi.org/10.1038/s41467-021-22932-4
https://doi.org/10.1038/s41467-021-22932-4