Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Meghan B, O'Donoghue"'
Autor:
Ling Meng, Kwame Sefah, Meghan B O'Donoghue, Guizhi Zhu, Dihua Shangguan, Afshan Noorali, Yan Chen, Lei Zhou, Weihong Tan
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14018 (2010)
Protein tyrosine kinase-7 (PTK7) is a catalytically inactive receptor tyrosine kinase (RTK). PTK7 is upregulated in many common human cancers, including colon cancer, lung cancer, gastric cancer and acute myeloid leukemia. The reason for this up-regu
Externí odkaz:
https://doaj.org/article/cc8b58ef9b34478884d1560b93d82eb0
Publikováno v:
Analytical and Bioanalytical Chemistry. 402:3205-3209
Some researchers have questioned whether synthetic aptamers bind as robustly as natural antibodies. To address this issue, we used single-molecule atomic force microscopy to measure the rupture force between a protein and both its aptamer and its ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ead7d3d27e3d96baeff99881122ee5d
https://doi.org/10.1007/s00216-011-5667-y
https://doi.org/10.1007/s00216-011-5667-y
Autor:
Haipeng Liu, Joseph A. Phillips, Weihong Tan, Mingxu You, Ruowen Wang, Meghan B. O’Donoghue, Xiangling Xiong, Kwame Sefah
Publikováno v:
Bioconjugate Chemistry. 22:282-288
The rational design of DNA/RNA aptamers for use as molecular probes depends on a clear understanding of their structural elements in relation to target-aptamer binding interactions. We present a simple method to create aptamer probes that can occupy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6edf448628b9516513d755f28711acc
https://doi.org/10.1021/bc100402p
https://doi.org/10.1021/bc100402p
Autor:
Xiaolan Chen, M.-Carmen Estevez, Joseph A. Phillips, Yu-Fen Huang, Chaoyong James Yang, Yan Chen, Meghan B. O’Donoghue, Weihong Tan, Huaizhi Kang
Publikováno v:
Journal of the American Chemical Society. 132:16559-16570
Measuring distances at molecular length scales in living systems is a significant challenge. Methods like Förster resonance energy transfer (FRET) have limitations due to short detection distances and strict orientations. Recently, surface energy tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f69f28702bf534b8a08f8b600df1be
https://doi.org/10.1021/ja106360v
https://doi.org/10.1021/ja106360v
Publikováno v:
Nano Research. 2:448-461
Early and accurate diagnosis and treatment of cancer depend on rapid, sensitive, and selective detection of tumor cells. Current diagnosis of cancers, especially leukemia, relies on histology and flow cytometry using single dye-labeled antibodies. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195fdcc287fb531f3fd9467bf1267333
https://doi.org/10.1007/s12274-009-9041-8
https://doi.org/10.1007/s12274-009-9041-8
Publikováno v:
Langmuir. 24:1635-1639
In this paper, we report the preparation and characterization of fluorophore-free luminescent organosilica nanoparticles (NPs) with sizes varying from 50 to 250 nm. These NPs were synthesized by the Stöber method by incorporating several organosilan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda48bd8c7e4f0871d85139e0f72f6a9
https://doi.org/10.1021/la703392m
https://doi.org/10.1021/la703392m
Publikováno v:
Bioconjugate Chemistry. 18:297-301
Rapid, sensitive, and selective detection of pathogenic bacteria is extremely important for proper containment, diagnosis, and treatment of diseases like foodborne illness, sepsis, and bioterrorism. Most current bacterial detection methods are time-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10e4c91770a1483bf76b411abcb4051
https://doi.org/10.1021/bc060255n
https://doi.org/10.1021/bc060255n
Publikováno v:
Nanomedicine. 1:413-426
The drive to understand biology and medicine at the molecular level with accurate quantitation demands much of current high-throughput analysis systems. Nanomaterials and nanotechnology combined with modern instrumentation have the potential to addre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7adf6205119280163fb8629101bcfb9e
https://doi.org/10.2217/17435889.1.4.413
https://doi.org/10.2217/17435889.1.4.413
Autor:
Stephen F. Larner, Erin C. Golden Bs, Zhiqun Zhang, Meghan B. O'Donoghue Bs, Firas H. Kobeissy Ms, Mark S. Gold
Publikováno v:
Journal of Addictive Diseases. 25:47-59
SUMMARY Since its emergence as a recreational club drug in the 1970s, 3-4 methylenedioxy-methamphetamine's usage, more commonly known as ecstasy or MDMA, has risen rapidly through the 1990s, mainly among the teens and young adults of the United State
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e6c47bd0dfb2a467d7abef56f93f01a
https://doi.org/10.1300/j069v25s01_05
https://doi.org/10.1300/j069v25s01_05
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57773e0a8cb46903854d7aadb0511f73
https://doi.org/10.1096/fasebj.26.1_supplement.657.10
https://doi.org/10.1096/fasebj.26.1_supplement.657.10