Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Meghan A. Wynosky-Dolfi"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The discovery of gasdermin D (GSDMD) as the terminal executioner of pyroptosis provided a large piece of the cell death puzzle, whilst simultaneously and firmly putting the gasdermin family into the limelight. In its purest form, GSDMD provides a con
Externí odkaz:
https://doaj.org/article/52dd730f04d149e29d081b2c0416c896
Autor:
Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A. Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N. Savvides, Albert J. R. Heck, Peter Vandenabeele, Igor E. Brodsky, Mathieu J. M. Bertrand
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
RIPK1 kinase activity is known to transduce a death signal, but the molecular mechanisms that normally prevent RIPK1 activation are unclear. Here, the authors report that IKK-mediated phosphorylation on RIPK1 Ser25 directly represses its enzymatic ac
Externí odkaz:
https://doaj.org/article/09b6a96e862a47278fdf07e7af978602
Autor:
Erin E. Zwack, Annelise G. Snyder, Meghan A. Wynosky-Dolfi, Gordon Ruthel, Naomi H. Philip, Melanie M. Marketon, Matthew S. Francis, James B. Bliska, Igor E. Brodsky
Publikováno v:
mBio, Vol 6, Iss 1 (2015)
ABSTRACT Type III secretion systems (T3SS) translocate effector proteins into target cells in order to disrupt or modulate host cell signaling pathways and establish replicative niches. However, recognition of T3SS activity by cytosolic pattern recog
Externí odkaz:
https://doaj.org/article/7f64c014a5aa4c928925802ef24e358f
Autor:
James P. Grayczyk, Marisa S. Egan, Luying Liu, Emily Aunins, Meghan A. Wynosky-Dolfi, Scott Canna, Andy J. Minn, Sunny Shin, Igor E. Brodsky
Publikováno v:
bioRxiv
NLR family, apoptosis inhibitory proteins (NAIPs) detect bacterial flagellin and structurally related components of bacterial type III secretion systems (T3SS), and recruit NLR family, CARD domain containing protein 4 (NLRC4) and caspase-1 into an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab2db818611498cc590dfac6c0cade1
https://europepmc.org/articles/PMC10187295/
https://europepmc.org/articles/PMC10187295/
Autor:
Alexandra DeLaney, Opher S. Kornfeld, Bettina L. Lee, Daniel P. Beiting, Eric M. Rodriguez Lopez, Petr Broz, Timothée Fettrelet, Jorge Henao-Mejia, Daniel Grubaugh, Elisabet Bjanes, Benjamin Demarco, Reyna Garcia Sillas, Elise Krespan, Kaiwen W. Chen, Igor E. Brodsky, Meghan A. Wynosky-Dolfi, Dorothy Tovar, Rina Matsuda, Naomi H. Philip, Leonel Joannas, Brian C. Schaefer
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009967 (2021)
PLoS Pathogens
Plos Pathogens
PLoS pathogens, vol. 17, no. 10, pp. e1009967
PLoS Pathogens
Plos Pathogens
PLoS pathogens, vol. 17, no. 10, pp. e1009967
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokine release.
Autor:
Meghan A. Wynosky-Dolfi, Elise Krespan, Reyna Garcia Sillas, Petr Broz, Opher S. Kornfeld, Kaiwen W. Chen, Jorge Henao-Mejia, Daniel Grubaugh, Elisabet Bjanes, Timothée Fettrelet, Alexandra DeLaney, Benjamin Demarco, Rina Matsuda, Dorothy Tovar, Eric M. Rodriguez Lopez, Naomi H. Philip, Leonel Joannas, Brian C. Schaefer, Daniel P. Beiting, Igor E. Brodsky, Bettina L. Lee
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokine release.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d4e82de528db10234c8640e54e62584
https://doi.org/10.1101/2021.03.19.436207
https://doi.org/10.1101/2021.03.19.436207
Autor:
Meghan A. Wynosky-Dolfi, B. Brett Finlay, Igor E. Brodsky, Sergei I. Grivennikov, Çagla Tükel, Kathy Q. Cai, Masahiro Yamamoto, Joris van der Heijden, Justin P. Ingram, Ting Zhang, Siddharth Balachandran, Sarah A. Tursi, Wei Guo, Chaoran Yin
Publikováno v:
The Journal of Immunology. 200:3626-3634
The cytokine IFN-γ has well-established antibacterial properties against the bacterium Salmonella enterica in phagocytes, but less is known about the effects of IFN-γ on Salmonella-infected nonphagocytic cells, such as intestinal epithelial cells (
Autor:
Baofeng Hu, Igor E. Brodsky, Ruth Choa, Kendra Asklof, Elisabet Bjanes, Elisabeth L. Buza, Alexandra DeLaney, Falon Gray, Lance W. Peterson, Meghan A. Wynosky-Dolfi, Christopher P. Dillon, Peter J. Gough, Douglas R. Green, Naomi H. Philip, Scott B. Berger, John Bertin
Publikováno v:
The Journal of Experimental Medicine
RIPK1 regulates cytokine signaling and cell death during infection and inflammation. Peterson et al. show that RIPK1 kinase activity triggers apoptosis in response to bacterial pathogen blockade of innate immune signaling and that this pathway of eff
Autor:
Alexandra A, DeLaney, Corbett T, Berry, David A, Christian, Andrew, Hart, Elisabet, Bjanes, Meghan A, Wynosky-Dolfi, Xinyuan, Li, Bart, Tummers, Irina A, Udalova, Youhai H, Chen, Uri, Hershberg, Bruce D, Freedman, Christopher A, Hunter, Igor E, Brodsky
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(24)
Caspase-8 is a key integrator of cell survival and cell death decisions during infection and inflammation. Following engagement of tumor necrosis factor superfamily receptors or certain Toll-like receptors (TLRs), caspase-8 initiates cell-extrinsic a
Autor:
Meghan A. Wynosky-Dolfi, Michael S. Marks, Adriana R. Mantegazza, Igor E. Brodsky, Sunny Shin, Ariel J Lefkovith, Cierra N. Casson
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006785 (2017)
PLoS Pathogens
PLoS Pathogens
Bacterial pathogens that compromise phagosomal membranes stimulate inflammasome assembly in the cytosol, but the molecular mechanisms by which membrane dynamics regulate inflammasome activity are poorly characterized. We show that in murine dendritic