Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Meghan A Rego"'
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81387 (2013)
Fanconi anemia (FA) is a rare recessive disease, characterized by congenital defects, bone marrow failure, and increased cancer susceptibility. FA is caused by biallelic mutation of any one of sixteen genes. The protein products of these genes functi
Externí odkaz:
https://doaj.org/article/8e1eb78d59c94aae87e4ae5e4ac3e7a4
Autor:
Alanna Mitsopoulos, Erin Sanders, K. Guerin, Michelle Tillgren, Maya Kostman, Ina Ersing, Isabelle Mueller, Meron Tasissa, Kate Harten DeMaio, Meghan A. Rego, Luke Hanley, Leila Haery, Melina Fan, Daniela Bourges
Publikováno v:
Human Gene Therapy
Recombinant adeno-associated virus (rAAV) vectors are increasingly popular gene delivery tools in biological systems. They are safe and lead to high-level, long-term transgene expression. rAAV are available in multiple serotypes, natural or engineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf2544e51b4c18a64273f861a46cd78
https://doi.org/10.1089/hum.2019.277
https://doi.org/10.1089/hum.2019.277
Autor:
Jae-Hyun Yang, Motoshi Hayano, Patrick T. Griffin, João A. Amorim, Michael S. Bonkowski, John K. Apostolides, Elias L. Salfati, Marco Blanchette, Elizabeth M. Munding, Mital Bhakta, Yap Ching Chew, Wei Guo, Xiaojing Yang, Sun Maybury-Lewis, Xiao Tian, Jaime M. Ross, Giuseppe Coppotelli, Margarita V. Meer, Ryan Rogers-Hammond, Daniel L. Vera, Yuancheng Ryan Lu, Jeffrey W. Pippin, Michael L. Creswell, Zhixun Dou, Caiyue Xu, Sarah J. Mitchell, Abhirup Das, Brendan L. O’Connell, Sachin Thakur, Alice E. Kane, Qiao Su, Yasuaki Mohri, Emi K. Nishimura, Laura Schaevitz, Neha Garg, Ana-Maria Balta, Meghan A. Rego, Meredith Gregory-Ksander, Tatjana C. Jakobs, Lei Zhong, Hiroko Wakimoto, Jihad El Andari, Dirk Grimm, Raul Mostoslavsky, Amy J. Wagers, Kazuo Tsubota, Stephen J. Bonasera, Carlos M. Palmeira, Jonathan G. Seidman, Christine E. Seidman, Norman S. Wolf, Jill A. Kreiling, John M. Sedivy, George F. Murphy, Richard E. Green, Benjamin A. Garcia, Shelley L. Berger, Philipp Oberdoerffer, Stuart J. Shankland, Vadim N. Gladyshev, Bruce R. Ksander, Andreas R. Pfenning, Luis A. Rajman, David A. Sinclair
Publikováno v:
Cell. 186:305-326.e27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a40d556fd25f6db5d4a9f1a0234305aa
https://doi.org/10.1016/j.cell.2022.12.027
https://doi.org/10.1016/j.cell.2022.12.027
Autor:
Brendan O'Connell, Xiaojing Yang, Jaime M. Ross, Yuancheng Lu, Jonathan G. Seidman, Mital Bhakta, Amy J. Wagers, João A. Amorim, Qiao Su, Bruce R. Ksander, Jae-Hyun Yang, Jill A. Kreiling, Elias L. Salfati, Stuart J. Shankland, Richard E. Green, Christine E. Seidman, Ana-Maria Balta, Andreas R. Pfenning, George F. Murphy, Michael Bonkowski, Benjamin A. Garcia, Luis A. Rajman, Patrick Griffin, Marco Blanchette, Yasuaki Mohri, Meghan A. Rego, Sarah J. Mitchell, Meredith S Gregory-Ksander, Kazuo Tsubota, Sachin Thakur, Raul Mostoslavsky, Caiyue Xu, Hiroko Wakimoto, John M. Sedivy, Norman S. Wolf, Philipp Oberdoerffer, Yap Ching Chew, John K. Apostolides, Alice E. Kane, Michael L. Creswell, Laura Schaevitz, Motoshi Hayano, Zhixun Dou, Margarita V. Meer, Giuseppe Coppotelli, Elizabeth M. Munding, Xiao Tian, Carlos M. Palmeira, Wei Guo, Shelley L. Berger, Tatjana C. Jakobs, Daniel L. Vera, Emi K. Nishimura, Lei Zhong, David A. Sinclair, Abhirup Das, Jeffrey W. Pippin, Vadim N. Gladyshev, Stephen J. Bonasera, Neha Garg
Publikováno v:
SSRN Electronic Journal.
All living things experience entropy, manifested as a loss of inherited genetic and epigenetic information over time. In yeast, epigenetic changes result in a loss of cell identity and sterility, both hallmarks of yeast aging. In mammals, epigenetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::245f07f1a3ddd3b145824aa1a6d8802f
https://doi.org/10.2139/ssrn.3951490
https://doi.org/10.2139/ssrn.3951490
Autor:
Jada L. Garzon, Meghan A. Rego, Niall G. Howlett, Morganne M. Adroved, Maurizio Mauro, David A. Vierra
Publikováno v:
Oncotarget
// David A. Vierra 1 , Jada L. Garzon 1 , Meghan A. Rego 2 , Morganne M. Adroved 1 , Maurizio Mauro 3 and Niall G. Howlett 1 1 Department of Cell and Molecular Biology, University of Rhode Island, Kingston, Rhode Island, U.S.A 2 Addgene, Cambridge, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983d9e667dfa1c51bfa3f5e61d25e7de
https://doi.org/10.18632/oncotarget.19470
https://doi.org/10.18632/oncotarget.19470
Autor:
Leila Haery, Benjamin E. Deverman, Katherine S. Matho, Ali Cetin, Kenton Woodard, Connie Cepko, Karen I. Guerin, Meghan A. Rego, Ina Ersing, Susanna M. Bachle, Joanne Kamens, Melina Fan
Publikováno v:
Frontiers in Neuroanatomy
Frontiers in Neuroanatomy, Vol 13 (2019)
Frontiers in Neuroanatomy, Vol 13 (2019)
Cell-type-specific expression of molecular tools and sensors is critical to construct circuit diagrams and to investigate the activity and function of neurons within the nervous system. Strategies for targeted manipulation include combinations of cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7f3a110761f79fd1d09e3e7c4040df
https://pubmed.ncbi.nlm.nih.gov/31849618
https://pubmed.ncbi.nlm.nih.gov/31849618
Autor:
Karen I. Guerin, Luke Hanley, Leila Haery, Ina Ersing, Meghan A. Rego, Erin Sanders, Melina Fan, Isabelle Mueller, Meron Tasissa
Hyperosmolarity has been used as a means to improve yields in various processes such as antibody production in hybridoma cells and retroviral and adenoviral production systems. In this study we demonstrate that treatment of AAVpro 293T packaging cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7a99445ba42cb7fae8f87a22d8df2b
Autor:
Rebecca A. Boisvert, Francesca Cavallo, Meghan A. Rego, Niall G. Howlett, Fumiko Esashi, Maurizio Mauro, Maria Jasin
Publikováno v:
Nucleic Acids Research
p21 is a well-established regulator of cell cycle progression. The role of p21 in DNA repair, however, remains poorly characterized. Here, we describe a critical role of p21 in a replication-coupled DNA double-strand break (DSB) repair that is mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59950a2210d6e6679b41b164f610c2a3
https://ora.ox.ac.uk/objects/uuid:86d55a26-08f8-4a12-b4b4-be4a98edf5c0
https://ora.ox.ac.uk/objects/uuid:86d55a26-08f8-4a12-b4b4-be4a98edf5c0
Publikováno v:
Blood. 120:2109-2117
The Fanconi anemia (FA)–BRCA pathway is critical for the repair of DNA interstrand crosslinks (ICLs) and the maintenance of chromosome stability. A key step in FA-BRCA pathway activation is the covalent attachment of monoubiquitin to FANCD2 and FAN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe3bad3e771f2bb6f060b83021a106c
https://doi.org/10.1182/blood-2012-02-410472
https://doi.org/10.1182/blood-2012-02-410472
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 668:27-41
It has long been hypothesized that a defect in the repair of damaged DNA is central to the etiology of Fanconi anemia (FA). Indeed, an increased sensitivity of FA patient-derived cells to the lethal effects of various forms of DNA damaging agents was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6181ecf21bef7f20e49ec27fa977010
https://doi.org/10.1016/j.mrfmmm.2008.11.018
https://doi.org/10.1016/j.mrfmmm.2008.11.018