Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Meghan A Arnold"'
Autor:
Gary Weiner, George B Mychaliska, Niki Matusko, Nathan Rubalcava, Gabriella A Norwitz, Aimee G Kim, Meghan A Arnold, Erin E Perrone
Publikováno v:
World Journal of Pediatric Surgery, Vol 5, Iss 3 (2022)
Externí odkaz:
https://doaj.org/article/857a0822a8be4d0789981f2acce2e513
Autor:
Meghan Lee Arnold, Jason Cooper, Rebecca Androwski, Sohil Ardeshna, Ilija Melentijevic, Joelle Smart, Ryan J. Guasp, Ken C. Q. Nguyen, Ge Bai, David H. Hall, Barth D. Grant, Monica Driscoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Toxic protein aggregates can spread among neurons to promote human neurodegenerative disease pathology. We found that in C. elegans touch neurons intermediate filament proteins IFD-1 and IFD-2 associate with aggresome-like organelles and are
Externí odkaz:
https://doaj.org/article/7789921720d54283b486c645e8eba774
Autor:
Yu Wang, Meghan Lee Arnold, Anna Joelle Smart, Guoqiang Wang, Rebecca J Androwski, Andres Morera, Ken CQ Nguyen, Peter J Schweinsberg, Ge Bai, Jason Cooper, David H Hall, Monica Driscoll, Barth D Grant
Publikováno v:
eLife, Vol 12 (2023)
Caenorhabditis elegans neurons under stress can produce giant vesicles, several microns in diameter, called exophers. Current models suggest that exophers are neuroprotective, providing a mechanism for stressed neurons to eject toxic protein aggregat
Externí odkaz:
https://doaj.org/article/f03cd4354e174bee8cd967a06a26154e
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-7 (2018)
Abstract Caenorhabditis elegans neurons have recently been found to throw out cellular debris for remote degradation and/or storage, adding an “extracellular garbage elimination” option to known intracellular protein and organelle degradation pat
Externí odkaz:
https://doaj.org/article/30eec02dc5424365823aaa6f8d7dd382
Autor:
Yu Wang, Meghan Lee Arnold, Anna Joelle Smart, Guoqiang Wang, Rebecca J Androwski, Andres Morera, Ken CQ Nguyen, Peter J Schweinsberg, Ge Bai, Jason Cooper, David H Hall, Monica Driscoll, Barth D Grant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f361086e9108b0a30c519da4da98563
https://doi.org/10.7554/elife.82227.sa2
https://doi.org/10.7554/elife.82227.sa2
Autor:
Yongzhi Yang, Meghan Lee Arnold, Elizabeth H. Choy, Caitlin M. Lange, Karie Poon, Michael Broussalian, Ling-Hsuan Sun, Tatiana M. Moreno, Anupama Singh, Monica Driscoll, Caroline Kumsta, Malene Hansen
While autophagy is key to maintain cellular homeostasis, tissue-specific roles of individual autophagy genes are less understood. To study neuronal autophagyin vivo, we inhibited autophagy genes specifically inC. elegansneurons, and unexpectedly foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf84ef9b09dfc1f272f6e5460f393f49
https://doi.org/10.1101/2022.12.12.520171
https://doi.org/10.1101/2022.12.12.520171
Autor:
Meghan Lee Arnold, Jason Cooper, Rebecca Androwski, Sohil Ardeshna, Ilija Melentijevic, Joelle Smart, Ryan J. Guasp, Ken C.Q. Nguyen, Ge Bai, David H. Hall, Barth D. Grant, Monica Driscoll
Under conditions of proteostasis disequilibrium, neurons can enhance intracellular and extracellular protective mechanisms to guard against neurotoxicity. In mammals, an intracellular response to severe proteostasis imbalance that results from proteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cd67597b046726c06f36991d5d63358
https://doi.org/10.1101/2022.08.03.501714
https://doi.org/10.1101/2022.08.03.501714
Autor:
Stephen L. Harvey, Brian P. Fallon, Jennifer S. McLeod, Niki Matusko, Raja Rabah, Meghan A. Arnold, Alvaro Rojas-Pena, Robert H. Bartlett, George B. Mychaliska
Publikováno v:
ASAIO J
The artificial placenta (AP) promotes organ development and reduces organ injury in a lamb model of extreme prematurity. This study evaluates hepatic outcomes after AP support with total parenteral nutrition (TPN) administration. Premature lambs (116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72431648dc0bf16b9de685af11767ec8
https://europepmc.org/articles/PMC9246820/
https://europepmc.org/articles/PMC9246820/
Autor:
George B. Mychaliska, Meghan A. Arnold, Marcus D. Jarboe, Ronald B. Hirschl, Mercedes Pilkington, Samir K. Gadepalli
Publikováno v:
Journal of Pediatric Surgery. 55:29-32
Background The practice of “cutting-away” from venoarterial extracorporeal life support (ECLS) and leaving indwelling heparinized cannulas prior to decannulation is controversial. This study aims to determine the safety and efficacy of this strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f5b71d9e1b926647a5fd7ca3772a57
https://doi.org/10.1016/j.jpedsurg.2019.09.070
https://doi.org/10.1016/j.jpedsurg.2019.09.070
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance In neurodegenerative disease, protein aggregates spread to neighboring cells to promote pathology. The in vivo regulation of toxic material transfer remains poorly understood, although mechanistic understanding should reveal previously u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7249fd4c969248c1b2ec77969cc9aa39
http://europepmc.org/articles/PMC8433523
http://europepmc.org/articles/PMC8433523