Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Meghan, Gage"'
Autor:
Suraj S. Vasanthi, Nikhil S. Rao, Manikandan Samidurai, Nyzil Massey, Christina Meyer, Meghan Gage, Mihir Kharate, Aida Almanza, Logan Wachter, Candide Mafuta, Lily Trevino, Adriana M. Carlo, Elijah Bryant, Brooke E. Corson, Morgan Wohlgemuth, Morgan Ostrander, Lucas Showman, Chong Wang, Thimmasettappa Thippeswamy
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-25 (2023)
Abstract Background Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate status epilepticus (SE), reactive gliosis, neurodegeneration,
Externí odkaz:
https://doaj.org/article/27b5448e94704f1a86180ed9deaf58b0
Autor:
Meghan Gage, Suraj S Vasanthi, Christina M Meyer, Nikhil S Rao, Daniel R Thedens, Sridhar S. Kannurpatti, Thimmasettappa Thippeswamy
Publikováno v:
Epilepsia Open, Vol 8, Iss 2, Pp 399-410 (2023)
Abstract Objective Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex
Externí odkaz:
https://doaj.org/article/5cf3a7149c2048d9ab198687bb4291b4
Autor:
Christina Meyer, Nikhil S. Rao, Suraj S. Vasanthi, Beatriz Pereira, Meghan Gage, Marson Putra, Claire Holtkamp, Joselyn Huss, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Organophosphates (OP) are highly toxic chemical nerve agents that have been used in chemical warfare. Currently, there are no effective medical countermeasures (MCMs) that mitigate the chronic effects of OP exposure. Oxidative stress is a key mechani
Externí odkaz:
https://doaj.org/article/ee60e460bdda414980be652438df1986
Autor:
Nyzil Massey, Suraj Sundara Vasanthi, Manikandan Samidurai, Meghan Gage, Nikhil Rao, Christina Meyer, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Organophosphate nerve agent (OPNA) exposure induces acute and long-term neurological deficits. OPNA exposure at sub-lethal concentrations induces irreversible inhibition of acetylcholinesterase and cholinergic toxidrome and develops status epilepticu
Externí odkaz:
https://doaj.org/article/5bcec7d195a74a1fbab94e68ca61bb2b
Autor:
Nikhil S. Rao, Christina Meyer, Suraj S. Vasanthi, Nyzil Massey, Manikandan Samidurai, Meghan Gage, Marson Putra, Aida N. Almanza, Logan Wachter, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Sex is a biological variable in experimental models. In our previous diisopropylfluorophosphate (DFP) studies, female rats required a higher dose of DFP to achieve a somewhat similar severity of status epilepticus (SE) as males. In those studies, mal
Externí odkaz:
https://doaj.org/article/3365a7c48d5447a38cc68c990cfcd13b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Glial scars have been observed following stab lesions in the spinal cord and brain but not observed and characterized in chemoconvulsant-induced epilepsy models. Epilepsy is a disorder characterized by spontaneous recurrent seizures and can be modele
Externí odkaz:
https://doaj.org/article/fdc35e6a47914793b6654177cc467f6b
Autor:
Meghan Gage, Nikhil S. Rao, Manikandan Samidurai, Marson Putra, Suraj S. Vasanthi, Christina Meyer, Chong Wang, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Modeling a real-world scenario of organophosphate nerve agent (OPNA) exposure is challenging. Military personnel are premedicated with pyridostigmine, which led to the development of OPNA models with pyridostigmine/oxime pretreatment to investigate n
Externí odkaz:
https://doaj.org/article/631974d04d3d4aefa5b682931e544a3c
Autor:
Meghan Gage, Marson Putra, Crystal Gomez-Estrada, Madison Golden, Logan Wachter, Megan Gard, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Acute organophosphate (OP) toxicity poses a significant threat to both military and civilian personnel as it can lead to a variety of cholinergic symptoms including the development of status epilepticus (SE). Depending on its severity, SE can lead to
Externí odkaz:
https://doaj.org/article/f3f8aabf783b450db21df5b8a538e0c4
Autor:
Marson Putra, Shaunik Sharma, Meghan Gage, Grace Gasser, Andy Hinojo-Perez, Ashley Olson, Adriana Gregory-Flores, Sreekanth Puttachary, Chong Wang, Vellareddy Anantharam, Thimmasettappa Thippeswamy
Publikováno v:
Neurobiology of Disease, Vol 133, Iss , Pp - (2020)
Chemical nerve agents (CNA) are increasingly becoming a threat to both civilians and military personnel. CNA-induced acute effects on the nervous system have been known for some time and the long-term consequences are beginning to emerge. In this stu
Externí odkaz:
https://doaj.org/article/ec8378c734124560a9373eeab90c8b8f
Autor:
Meghan Gage, Marson Putra, Logan Wachter, Kylie Dishman, Megan Gard, Crystal Gomez-Estrada, Thimmasettappa Thippeswamy
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 61 (2021)
Diisopropylfluorophosphate (DFP), an organophosphate nerve agent (OPNA), exposure causes status epilepticus (SE) and epileptogenesis. In this study, we tested the protective effects of saracatinib (AZD0530), a Src kinase inhibitor, in mixed-sex or ma
Externí odkaz:
https://doaj.org/article/b173e9d9b119403fb5059d593f6e9aa9