Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Meghah, Vuppalapaty"'
Autor:
Haiyan E. Liu, Meghah Vuppalapaty, Christian R. Hoerner, Colin P. Bergstrom, Michael Chiu, Clementine Lemaire, James Che, Amanpreet Kaur, Adam Dimmick, Sean Liu, Thomas J. Metzner, Menna Araya, Steve Crouse, Markus Sprenger-Haussels, Martin Schlumpberger, John T. Leppert, Siegfried Hauch, Elodie Sollier, Alice C. Fan
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Therapies for metastatic castration-resistant prostate cancer (mCRPC) include targeting the androgen receptor (AR) with androgen receptor inhibitors (ARIs) and prostate-specific membrane antigen (PSMA). Having the ability to detec
Externí odkaz:
https://doaj.org/article/f147876cb7db462d84fa5bc412a8c4d4
Autor:
Hui Chen, Sung-Jin Lee, Ryan Li, Asmiti Sura, Nicholas Suen, Archana Dilip, Yan Pomogov, Meghah Vuppalapaty, Timothy T Suen, Chenggang Lu, Yorick Post, Yang Li
Publikováno v:
eLife, Vol 12 (2024)
Systemic toxicity is a major challenge in the development of therapeutics. Consequently, cell-type-specific targeting is needed to improve on-target efficacy while reducing off-target toxicity. Here, we describe a cell-targeting system we have termed
Externí odkaz:
https://doaj.org/article/b18a4fedb9594fe39bd8ab03b0fe2af9
Autor:
Jie Ding, Sung-Jin Lee, Lukas Vlahos, Kanako Yuki, Cara C. Rada, Vincent van Unen, Meghah Vuppalapaty, Hui Chen, Asmiti Sura, Aaron K. McCormick, Madeline Tomaske, Samira Alwahabi, Huy Nguyen, William Nowatzke, Lily Kim, Lisa Kelly, Douglas Vollrath, Andrea Califano, Wen-Chen Yeh, Yang Li, Calvin J. Kuo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer’s disease. The Norrin/FZD4/TSPAN12 pathway activates WNT/β-catenin signaling,
Externí odkaz:
https://doaj.org/article/31df630cc0d74d1eb51da2d91c5e7f3c
Autor:
Tristan W. Fowler, Troy L. Mitchell, Claudia Y. Janda, Liqin Xie, Shengjiang Tu, Hui Chen, Haili Zhang, Jingjing Ye, Brian Ouyang, Tom Z. Yuan, Sung-Jin Lee, Maureen Newman, Nikita Tripuraneni, Erica S. Rego, Devin Mutha, Archana Dilip, Meghah Vuppalapaty, Helene Baribault, Wen-Chen Yeh, Yang Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Antibody-based Wnt agonists are able to phenocopy Wnt signaling in vivo resulting in increased bone density, repair, and strength. Here, the authors show that Wnt agonists can reverse bone loss associated with ovariectomy and build stronger bone when
Externí odkaz:
https://doaj.org/article/f832347476cc4872864883076749da99
Autor:
Haiyan E. Liu, Meghah Vuppalapaty, Charles Wilkerson, Corinne Renier, Michael Chiu, Clementine Lemaire, James Che, Melissa Matsumoto, James Carroll, Steve Crouse, Violet R. Hanft, Stefanie S. Jeffrey, Dino Di Carlo, Edward B. Garon, Jonathan Goldman, Elodie Sollier
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Lung cancer is the leading cause of cancer-related mortality worldwide. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapies, based on the evaluation of EGFR mutations, have shown dramatic clinical benefits. EGFR mutation
Externí odkaz:
https://doaj.org/article/723a9ab238364e0eb7b4e993350af58a
Autor:
Purushothaman, Sruthi, Saxena, Sandeep, Meghah, Vuppalapaty, Swamy, Cherukuvada V. Brahmendra, Ortega-Martinez, Olga, Dupont, Sam, Idris, Mohammed
Publikováno v:
In Journal of Proteomics 1 January 2015 112:113-124
Autor:
Jie Ding, Sung-Jin Lee, Lukas Vlahos, Kanako Yuki, Cara C. Rada, Vincent van Unen, Meghah Vuppalapaty, Hui Chen, Asmiti Sura, Aaron K. McCormick, Madeline Tomaske, Samira Alwahabi, Huy Nguyen, William Nowatzke, Lily Kim, Lisa Kelly, Douglas Vollrath, Andrea J. Califano, Wen-Chen Yeh, Yang Li, Calvin J. Kuo
Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer’s disease. The Norrin/FZD4/TSPAN12 pathway activates WNT/β-catenin signaling, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19bbbd11a56b64e460faffbbd6fab7fb
https://doi.org/10.1101/2022.10.13.510564
https://doi.org/10.1101/2022.10.13.510564
Autor:
Troy L. Mitchell, Yang Li, Tom Z. Yuan, Meghah Vuppalapaty, Nikita Tripuraneni, Fowler Tristan William, Sung-Jin Lee, Jingjing Ye, Haili Zhang, Erica S. Rego, Hui Chen, Archana Dilip, Liqin Xie, Helene Baribault, Janda Claudia Yvonne, Wen-Chen Yeh, Shengjiang Tu, Maureen Newman, Brian Ouyang, Devin Mutha
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The Wnt signaling pathway is intricately connected with bone mass regulation in humans and rodent models. We designed an antibody-based platform that generates potent and selective Wnt mimetics. Using this platform, we engineer bi-specific Wnt mimeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b417c9384484d7b1c272b1f89bb76314
https://doaj.org/article/f832347476cc4872864883076749da99
https://doaj.org/article/f832347476cc4872864883076749da99
Autor:
Saxena, Sandeep ‡, Singh, Sachin K. ‡, Lakshmi, Mula G. Meena, Meghah, Vuppalapaty, Bhatti, Bhawna, Swamy, Cherukuvada V. Brahmendra, Sundaram, Curam S., Idris, Mohammed M. §
Publikováno v:
In Molecular & Cellular Proteomics June 2012 11(6)
Autor:
Saxena, Sandeep, Singh, Sachin K., Lakshmi, Mula G. Meena, Meghah, Vuppalapaty, Sundaram, Curam S., Swamy, Cherukuvada V. Brahmendra, Idris, Mohammed M.
Publikováno v:
In Journal of Proteomics 18 November 2011 74(12):2937-2947