Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Megha Talati"'
Autor:
Anna Hemnes, Niki Fortune, Katie Simon, Irina A. Trenary, Sheila Shay, Eric Austin, Jamey D. Young, Evan Britain, James West, Megha Talati
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundIn PAH metabolic abnormalities in multiple pathways are well-recognized features of right ventricular dysfunction, however, prior work has focused mainly on the use of a single “omic” modality to describe a single deranged pathway. We i
Externí odkaz:
https://doaj.org/article/22d6d48498684b8396f4cc91e68694e9
Autor:
Megha Talati, Evan Brittain, Vineet Agrawal, Niki Fortune, Katie Simon, Sheila Shay, Xiaofang Zeng, Michael L. Freeman, James West, Anna Hemnes
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionPulmonary arterial hypertension is a fatal cardiopulmonary disease. Leptin, a neuroendocrine hormone released by adipose tissue, has a complex relationship with cardiovascular diseases, including PAH. Leptin is thought to be an important
Externí odkaz:
https://doaj.org/article/18126b69c87e4ec29b237f8c7e6df4a2
Autor:
Vineet Agrawal, Anna R. Hemnes, Nicholas J. Shelburne, Niki Fortune, Julio L. Fuentes, Dan Colvin, Marion W. Calcutt, Megha Talati, Emily Poovey, James D. West, Evan L. Brittain
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Pulmonary arterial hypertension (PAH) is a fatal vasculopathy that ultimately leads to elevated pulmonary pressure and death by right ventricular (RV) failure, which occurs in part due to decreased fatty acid oxidation and cytotoxic lipid ac
Externí odkaz:
https://doaj.org/article/5f982da54b464a12a0b70bc83b5a374f
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Inflammatory cells contribute to irreversible damage in pulmonary arterial hypertension (PAH). We hypothesized that in PAH, dysfunctional BMPR2 signaling in macrophages contributes to pulmonary vascular injury and phenotypic changes via proinflammato
Externí odkaz:
https://doaj.org/article/b2ca2ce95abf40f3b2c721c1b28ad58a
Autor:
James West, Anandharajan Rathinasabapathy, Xinping Chen, Sheila Shay, Shanti Gladson, Megha Talati
Publikováno v:
Cells, Vol 10, Iss 9, p 2306 (2021)
Pulmonary arterial hypertension (PAH) is a progressive lung disease caused by thickening of the pulmonary arterial wall and luminal obliteration of the small peripheral arteries leading to increase in vascular resistance which elevates pulmonary arte
Externí odkaz:
https://doaj.org/article/aa1d05f70b594ca4b5fa3e08a43e797c
Autor:
Evan L. Brittain, Megha Talati, Niki Fortune, Vineet Agrawal, David F. Meoli, James West, Anna R. Hemnes
Publikováno v:
Pulmonary Circulation, Vol 9 (2018)
Little is known about the impact of metabolic syndrome (MS) on right ventricular (RV) structure and function. We hypothesized that mice fed a Western diet (WD) would develop RV lipid accumulation and impaired RV function, which would be ameliorated w
Externí odkaz:
https://doaj.org/article/c7ad4f5fd05b48039ada68cc7678f67d
Autor:
Megha Talati, Haitham Mutlak, Kirk B. Lane, Wei Han, Anna Hemnes, Outi Mutlak, Tom Blackwell, Rinat Zaynagetdinov, Timothy S. Blackwell, James West
Publikováno v:
Diseases, Vol 2, Iss 2, Pp 148-167 (2014)
Aim: The present study investigates the role of NF-κB in Bmpr2-related pulmonary hypertension (PH) using a murine model of PH with inducible overexpression of a cytoplasmic tail Bmpr2 mutation. Methods and Results: Electrophoretic mobility shift ass
Externí odkaz:
https://doaj.org/article/df81727870de4bbc8cebe6c5402aeeca
Autor:
Megha Talati, James West, Rinat Zaynagetdinov, Charles C Hong, Wei Han, Tom Blackwell, Linda Robinson, Timothy S Blackwell, Kirk Lane
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94119 (2014)
Pulmonary arterial hypertension (PAH) is a disease of progressively increasing pulmonary vascular resistance, associated with mutations of the type 2 receptor for the BMP pathway, BMPR2. The canonical signaling pathway for BMPR2 is through the SMAD f
Externí odkaz:
https://doaj.org/article/08156025a98f4e33bd178f47388b0811
Autor:
Xinping Chen, Santhi Gladson, Megha Talati, Ling Ping, James West, Rizwan Hamid, James E Lloyd
Publikováno v:
Pulmonary Circulation
Pulmonary Circulation, Vol 10 (2020)
Pulmonary Circulation, Vol 10 (2020)
Inflammatory cells contribute to irreversible damage in pulmonary arterial hypertension (PAH). We hypothesized that in PAH, dysfunctional BMPR2 signaling in macrophages contributes to pulmonary vascular injury and phenotypic changes via proinflammato
Autor:
Megha Talati, James West, Anandharajan Rathinasabapathy, Xinping Chen, Sheila Shay, Shanti Gladson
Publikováno v:
Cells
Volume 10
Issue 9
Cells, Vol 10, Iss 2306, p 2306 (2021)
Volume 10
Issue 9
Cells, Vol 10, Iss 2306, p 2306 (2021)
Pulmonary arterial hypertension (PAH) is a progressive lung disease caused by thickening of the pulmonary arterial wall and luminal obliteration of the small peripheral arteries leading to increase in vascular resistance which elevates pulmonary arte