Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Megha Marathe"'
Autor:
Harshada Desai, Megha Marathe, Varada Potdar, Prabhakar Tiwari, Ashwini Joshi, Sheetal R. Kadam, Arti Rajesh Joshi, Abhay Kulkarni, Vikram Bhosale, Avinash Hadambar, Bhavik Lodhiya, Venkatesha Udupa, Dayanidhi Behera, Sachin S. Chaudhari, Sanjib Das, Malini Bajpai, Nagaraj Gowda, Pravin S. Iyer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The role of RORγ as a transcription factor for Th17 cell differentiation and thereby regulation of IL-17 levels is well known. Increased RORγ expression along with IL-17A levels was observed in animal models, immune cells and BAL fluid of
Externí odkaz:
https://doaj.org/article/a7d1fc806fe64770a823646dd30ddaee
Autor:
Nagaraj Gowda, Sanjib Das, Sravan Mandadi, Jagmohan Saini, Sachin Chaudhari, Ameya Deshpande, Murugan Chinnapattu, Malini Bajpai, Priyanka Pangre, Varada Potdar, Megha Marathe, Pooja Sawant, Atul Akarte, Chandrasekhar Misra, Subhadip Das, Anuj Singh, Avratanu Das, Pandurang Lambade, Chaitanya Tirumalasetty, Raju Patole, Nilanjana Biswas, Vikas Karande, Heta Shah, Dayanidhi Behera, Pravin Iyer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/3b4b03f862394120b275158b7a6d0779
Autor:
Murugan Chinnapattu, Sandeep Shelke, Prashant Ingale, Nayan Waghmare, Nanasaheb Kadlag, Manoj Pawar, Akshay Kangane, Sachin S. Chaudhari, Jagmohan Saini, Vidya Kattige, Arti Joshi, Colina Dutta, Debjyoti Boral, Sheetal Kadam, Varada Potdar, Jiju Mani, Pooja Sawant, Megha Marathe, Madhavi Mulay, Akshata Virdikar, Sravan Mandadi, Atul Akarte, Anuj Singh, Chandrasekhar Misra, Pandurang Lambade, Chaitanya Tirumalasetty, Raju Patole, Vikas Karande, Dayanidhi Behera, Pankaj Jain, Vishwanath Kurawattimath, Nagaraj Gowda, Pravin S. Iyer
Publikováno v:
Cancer Research. 83:462-462
Background: Casitas B-lineage lymphoma b (Cbl-b), a RING finger E3 ligase, is a negative regulator of immune cell activation1. Genetic deletion or pharmacological inhibition of Cbl-b resulted in hyper-reactive and co-stimulation independent T cell ac
Autor:
Sravan Mandadi, Sanjib Das, Malini Bajpai, Jagmohan Saini, Murugan Chinnapattu, Sanjay Patale, Sandip Patil, Nanasaheb Kadlag, Nayan Waghmare, Balasaheb Gavhane, Ameya Deshpande, Dnyaneshwar Dahale, Vidya Kattige, Priyanka Pangre, Namrata Singh, Ekta Kashyap, Megha Marathe, Jiju Mani, Atul Akarte, Chandrasekhar Misra, Subhadip Das, Anuj Singh, Pandurang Lambade, Avratanu Das, Chaitanya Tirumalasetty, Raju Patole, Nilanjana Biswas, Vikas Karande, Heta Shah, Dayanidhi Behera, Pankaj Jain, Pavankumar Sancheti, Pramod Pawar, Vinod KR, Venkatesha Udupa, Sachin S. Chaudhari, Nagaraj Gowda, Pravin S. Iyer
Publikováno v:
Cancer Research. 83:463-463
Background: Pre-clinical profile of GRC 54276, a clinical candidate with Phase 1/2 clinical trial ongoing, is presented here. GRC 54276 is a novel small molecule inhibitor of Hematopoietic progenitor kinase 1 (HPK1), a serine/threonine kinase1,2 that
Autor:
Pooja Sawant, Ameya Deshpande, Pravin Iyer, Nagaraj Gowda, Avratanu Das, Megha Marathe, Dayanidhi Behera, Subhadip Das, Sravan Mandadi, Nilanjana Biswas, Priyanka Pangre, Heta Shah, Raju Patole, Murugan Chinnapattu, Vikas Karande, Sanjib Das, Pandurang Lambade, Sachin Sundarlal Chaudhari, Chandrasekhar Misra, Anuj Singh, Chaitanya Tirumalasetty, Jagmohan S. Saini, Varada Potdar, Malini Bajpai, Atul Akarte
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundHematopoietic progenitor kinase 1 (HPK1, MAP4K1), is a negative regulator of T and B cell receptor signaling.1 2 3 A strong anti-tumor immunogenic response and tumor rejection was observed in mice with HPK1 gene knocked out.3 Treatment of H
Autor:
Harshada Desai, Megha Marathe, Varada Potdar, Prabhakar Tiwari, Ashwini Joshi, Sheetal R. Kadam, Arti Rajesh Joshi, Abhay Kulkarni, Vikram Bhosale, Avinash Hadambar, Bhavik Lodhiya, Venkatesha Udupa, Dayanidhi Behera, Sachin S. Chaudhari, Sanjib Das, Malini Bajpai, Nagaraj Gowda, Pravin S. Iyer
Publikováno v:
Scientific reports. 12(1)
The role of RORγ as a transcription factor for Th17 cell differentiation and thereby regulation of IL-17 levels is well known. Increased RORγ expression along with IL-17A levels was observed in animal models, immune cells and BAL fluid of COPD pati
Autor:
Sravan Mandadi, Sanjib Das, Jagmohan Saini, Sachin S. Chaudhari, Murugan Chinnapattu, Ameya Deshpande, Dnyaneshwar Dahale, Malini Bajpai, Priyanka Pangre, Namrata Singh, Ekta Kashyap, Megha Marathe, Jiju Mani, Atul Akarte, Chandrasekhar Misra, Subhadip Das, Anuj Singh, Avratanu Das, Pandurang Lambade, Chaitanya Tirumalasetty, Raju Patole, Nilanjana Biswas, Vikas Karande, Heta Shah, Dayanidhi Behera, Pankaj Jain, Pavankumar Sancheti, Somesh Kakade, Pramod K. Pawar, Vinod KR, Venkatesha Udupa, Nagaraj Gowda, Pravin S. Iyer
Publikováno v:
Cancer Research. 82:1804-1804
Background Hematopoietic progenitor kinase 1 (HPK1) is a member of the mitogen-activated protein kinase (MAP4K) family of protein serine/threonine kinases1,2 and is a negative regulator of T and B cell receptor signaling3. Inhibition of HPK1 is an at
Autor:
Vijayshree B. Avhad, Rajendra L. Harde, Ashwini A. Joshi, Megha Marathe, Malini Bajpai, Satyawan Jadhav, Mahamad Yunnus A. Mahat, Praveen Kumar Gupta, Sanjib Das, Neelima Khairatkar-Joshi, Maulik Nitinkumar Gandhi, Girish S. Gudi, Deepak K. Bhateja, Srinivas Gullapalli, Shelke Dnyaneshwar Eknath, A. P. Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3238-3242
We report analogue-based rational design and synthesis of two novel series of polycyclic heteroarenes, pyrrolo[3,2-b]quinolines and pyrido[2,3-b]indoles, tethered to a biaryl system by a methyl-, ethyl- or propyl ether as PDE10A inhibitors. A number