Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Megha G. Basavappa"'
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101892- (2022)
Summary: Here, we describe a protocol to assess RNA-RNA interactions in situ using an adapted proximity ligation assay (PLA). We detail steps to perform RNA-probe hybridization, in situ rolling circle amplification, and immunofluorescence confocal mi
Externí odkaz:
https://doaj.org/article/ac4b8bc40171463ea283e9cdad430ffb
Autor:
Megha G. Basavappa, Max Ferretti, Mark Dittmar, Julian Stoute, Megan C. Sullivan, Kanupriya Whig, Hui Shen, Kathy Fange Liu, David C. Schultz, Daniel P. Beiting, Kristen W. Lynch, Jorge Henao-Mejia, Sara Cherry
Publikováno v:
Molecular cell. 82(19)
Arthropod-borne viruses, including the alphavirus chikungunya virus (CHIKV), cause acute disease in millions of people and utilize potent mechanisms to antagonize and circumvent innate immune pathways including the type I interferon (IFN) pathway. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afbd0f0df1cdbbac2d2b4eb2b99320e
https://pubmed.ncbi.nlm.nih.gov/36167073
https://pubmed.ncbi.nlm.nih.gov/36167073
Autor:
Vanessa D. Neal, Jasmine M. Wright, E. John Wherry, Fany Iseka, Megan L. Clark, Adam Williams, Sean P. Spencer, Jonathan J. Kotzin, Montserrat C. Anguera, Walter K. Mowel, Mohammed-Alkhatim Ali, Tanner F. Robertson, Camille M. Syrett, Mohamed S. Abdel-Hakeem, Megha G. Basavappa, Jorge Henao-Mejia, Leonel Joannas
Publikováno v:
Proceedings of the National Academy of Sciences. 116:11916-11925
The transcriptional programs that regulate CD8 T-cell differentiation and function in the context of viral infections or tumor immune surveillance have been extensively studied; yet how long noncoding RNAs (lncRNAs) and the loci that transcribe them
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29628fec32e8bec155d43477d60e5176
https://doi.org/10.1073/pnas.1819457116
https://doi.org/10.1073/pnas.1819457116
Publikováno v:
Journal of Leukocyte Biology. 106:83-93
Immune responses are both pathogen and cell type-specific. The innate arm of immunity is characterized by rapid intracellular signaling cascades resulting in the production of hundreds of antimicrobial effectors that protect the host organism. Long n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963e31719de075e37ec3d8fc74527f03
https://doi.org/10.1002/jlb.3mir0918-354r
https://doi.org/10.1002/jlb.3mir0918-354r
Autor:
Sara Cherry, Megha G. Basavappa
Publikováno v:
Mol Cell
Circular RNAs (circRNAs) are prevalent in eukaryotic cells and viral genomes. Mammalian cells possess innate immunity to detect foreign circRNAs, but the molecular basis of self vs. foreign identity in circRNA immunity is unknown. Here we show that N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4fd30e929ac003c934aec11ca5446d
https://pubmed.ncbi.nlm.nih.gov/31474572
https://pubmed.ncbi.nlm.nih.gov/31474572
Autor:
Jonathan J, Kotzin, Fany, Iseka, Jasmine, Wright, Megha G, Basavappa, Megan L, Clark, Mohammed-Alkhatim, Ali, Mohamed S, Abdel-Hakeem, Tanner F, Robertson, Walter K, Mowel, Leonel, Joannas, Vanessa D, Neal, Sean P, Spencer, Camille M, Syrett, Montserrat C, Anguera, Adam, Williams, E John, Wherry, Jorge, Henao-Mejia
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(24)
The transcriptional programs that regulate CD8 T-cell differentiation and function in the context of viral infections or tumor immune surveillance have been extensively studied; yet how long noncoding RNAs (lncRNAs) and the loci that transcribe them
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6535a5bdcccab888e27d8de649b1f068
https://pubmed.ncbi.nlm.nih.gov/31138702
https://pubmed.ncbi.nlm.nih.gov/31138702
The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs
Autor:
Sarah E. Henrickson, Maayan Levy, Monica T. Jimenez, Sam J. McCright, Sean P. Spencer, Megan L. Clark, Christoph A. Thaiss, Sasikanth Manne, Anthony Virtue, Stephen H. Eisennagel, Walter K. Mowel, Jonathan J. Kotzin, Megha G. Basavappa, Jorge Henao-Mejia, Adam Williams, E. John Wherry, Leonel Joannas, Jasmine M. Wright, Eran Elinav
Publikováno v:
Science Translational Medicine
The gut microbiota is a key environmental determinant of mammalian metabolism. Regulation of white adipose tissue (WAT) by the gut microbiota is a process critical to maintaining metabolic fitness, and gut dysbiosis can contribute to the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675688a9c5c9d86a5712adda2cf50bee
https://pubmed.ncbi.nlm.nih.gov/31189717
https://pubmed.ncbi.nlm.nih.gov/31189717