Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Megha, Ranganathan"'
Autor:
Yun Xu, Kai Liu, Cong Li, Minghan Li, Fangqi Liu, Xiaoyan Zhou, Menghong Sun, Megha Ranganathan, Liying Zhang, Sheng Wang, Xin Hu, Ye Xu
Publikováno v:
Research, Vol 6 (2023)
While genetic factors were associated with over 30% of colorectal cancer (CRC) patients, mutations in CRC-susceptibility genes were identified in only 5% to 10% of these patients. Besides, previous studies on hereditary CRC were largely designed to a
Externí odkaz:
https://doaj.org/article/d7af06624cd74ef982d52617bccae29f
Autor:
Sushmita Gordhandas, Eric Rios-Doria, Karen A Cadoo, Amanda Catchings, Anna Maio, Yelena Kemel, Margaret Sheehan, Megha Ranganathan, Dina Green, Anjali Aryamvally, Angela G Arnold, Erin Salo-Mullen, Beryl Manning-Geist, Tiffany Sia, Pier Selenica, Arnaud Da Cruz Paula, Chad Vanderbilt, Maksym Misyura, Mario M Leitao, Jennifer J Mueller, Vicky Makker, Maria Rubinstein, Claire F Friedman, Qin Zhou, Alexia Iasonos, Alicia Latham, Maria I Carlo, Yonina R Murciano-Goroff, Marie Will, Michael F Walsh, Shirin Issa Bhaloo, Lora H Ellenson, Ozge Ceyhan-Birsoy, Michael F Berger, Mark E Robson, Nadeem Abu-Rustum, Carol Aghajanian, Kenneth Offit, Zsofia Stadler, Britta Weigelt, Diana L Mandelker, Ying L Liu
Publikováno v:
JNCI: Journal of the National Cancer Institute. 115:560-569
Background We sought to determine the prevalence of germline pathogenic variants (gPVs) in unselected patients with endometrial cancer (EC), define biallelic gPVs within tumors, and describe their associations with clinicopathologic features. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec9f316b2b3f5be8abdd95005032897d
https://doi.org/10.1093/jnci/djad016
https://doi.org/10.1093/jnci/djad016
Autor:
Kelsey Breen, Zsofia K. Stadler, Rachel N. Grisham, Kara Long Roche, Deborah J. Goldfrank, Melissa K. Frey, Alicia Latham, Ying L Liu, Carol Aghajanian, Amanda Catchings, Dennis S. Chi, Kenneth Offit, Megha Ranganathan, Nadeem R. Abu-Rustum
Publikováno v:
JCO Oncology Practice. 18:201-209
Pathogenic germline variants underlie up to 20% of ovarian cancer (OC) and are associated with varying degrees of risk for OC. For mutations in high-penetrance genes such as BRCA1/ 2, the role of risk-reducing bilateral salpingo-oophorectomy (RRSO) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7dec283d5b7d1fa21111b11afbb046c
https://doi.org/10.1200/op.21.00382
https://doi.org/10.1200/op.21.00382
Autor:
Tony El Jabbour, Maksym Misyura, Darren Cowzer, Michal Zimmermann, Victoria Rimkunas, Antonio Marra, Fatemeh Derakhshan, Pier Selenica, Megan Parilla, Jeremy S Setton, Ozge Ceyhan-Birsoy, Yelena Kemel, Amanda Catchings, Megha Ranganathan, Geoffrey Y Ku, Yelena Y Janjigian, Michael Zinda, Maria Koehler, Zsofia Stadler, Jinru Shia, Jorge S Reis-Filho, Diana Mandelker
Publikováno v:
JNCI: Journal of the National Cancer Institute. 114:761-770
Background Gastroesophageal junction (GEJ) adenocarcinoma is a rare cancer associated with poor prognosis. The genetic factors conferring predisposition to GEJ adenocarcinoma have yet to be identified. Methods We analyzed germline testing results fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85ad2a13b42b7896a45a3e66f90a566
https://doi.org/10.1093/jnci/djac024
https://doi.org/10.1093/jnci/djac024
Autor:
David B. Solit, Angela G. Arnold, Mark E. Robson, Diana Mandelker, Michael F. Berger, Shweta S. Chavan, Maksym Misyura, Michael Walsh, Anna Maio, Sarah R. Kane, Karen Cadoo, Yelena Kemel, Preethi Srinivasan, Ying Liu, Jinru Shia, Kenneth Offit, Kelsey Breen, Jennifer Kennedy, Margaret Sheehan, Semanti Mukherjee, Caitlin Bourque, Chaitanya Bandlamudi, Zalak Patel, Maria I. Carlo, Zsofia K. Stadler, Amanda Catchings, Erin E. Salo-Mullen, Arnold J. Markowitz, Barry S. Taylor, Prince Rainier Tejada, Rosalba Sacca, Vanessa Marcell, Alicia Latham, Ozge Ceyhan-Birsoy, Mark T.A. Donoghue, Kimberly Amoroso, Megha Ranganathan
Publikováno v:
JCO Precision Oncology. :455-465
PURPOSE NTHL1 and MSH3 have been implicated as autosomal recessive cancer predisposition genes. Although individuals with biallelic NTHL1 and MSH3 pathogenic variants (PVs) have increased cancer and polyposis risk, risks for monoallelic carriers are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ba859253338af25f8aa87589967d494
https://doi.org/10.1200/po.20.00443
https://doi.org/10.1200/po.20.00443
Autor:
Muhammet Ozer, Megha Ranganathan, Nicolas Lecomte, Juan M. Schvartzman, Henry S. Walch, Walid K. Chatila, Jungeui Hong, Maria I. Carlo, Michael F. Walsh, Margaret Sheehan, Diana Mandelker, Ozge Ceyhan-Birsoy, Anna Maio, Yelena Kemel, Christine A. Iacobuzio-Donahue, Eileen M. O'Reilly, Kenneth H. Yu
Publikováno v:
JCO Precis Oncol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c06ddc089be2ac510b35c7cbbe1c700
https://doi.org/10.1200/po.21.00560
https://doi.org/10.1200/po.21.00560
Publikováno v:
Clinical Genetics. 99:133-142
Huntington's disease is associated with motor, cognitive and behavioral dysfunction. Behavioral symptoms may present before, after, or simultaneously with clinical disease manifestation. The relationship between age of onset and behavioral symptom pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188fda63f087fcde7f8de667dfe5a978
https://doi.org/10.1111/cge.13857
https://doi.org/10.1111/cge.13857
Autor:
Kelsey E. Breen, Bryson W. Katona, Amanda Catchings, Megha Ranganathan, Vanessa Marcell, Alicia Latham, Matthew B. Yurgelun, Zsofia K. Stadler
Publikováno v:
Genetics in medicine : official journal of the American College of Medical Genetics. 24(12)
With the recent guideline change for individuals at average risk for colorectal cancer (CRC) to initiate colonoscopy at the age of 45 years, there is a need to provide an updated counseling framework for individuals with variants in moderate-penetran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb48956878ed2766da254f638c4b26f
https://pubmed.ncbi.nlm.nih.gov/36222830
https://pubmed.ncbi.nlm.nih.gov/36222830
Autor:
Erin E, Salo-Mullen, Anna, Maio, Semanti, Mukherjee, Chaitanya, Bandlamudi, Jinru, Shia, Yelena, Kemel, Karen A, Cadoo, Ying, Liu, Maria, Carlo, Megha, Ranganathan, Sarah, Kane, Preethi, Srinivasan, Shweta S, Chavan, Mark T A, Donoghue, Caitlin, Bourque, Margaret, Sheehan, Prince Rainier, Tejada, Zalak, Patel, Angela G, Arnold, Jennifer A, Kennedy, Kimberly, Amoroso, Kelsey, Breen, Amanda, Catchings, Rosalba, Sacca, Vanessa, Marcell, Arnold J, Markowitz, Alicia, Latham, Michael, Walsh, Maksym, Misyura, Ozge, Ceyhan-Birsoy, David B, Solit, Michael F, Berger, Mark E, Robson, Barry S, Taylor, Kenneth, Offit, Diana, Mandelker, Zsofia K, Stadler
Publikováno v:
JCO Precis Oncol
NTHL1 and MSH3 have been implicated as autosomal recessive cancer predisposition genes. Although individuals with biallelic NTHL1 and MSH3 pathogenic variants (PVs) have increased cancer and polyposis risk, risks for monoallelic carriers are uncertai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::570d76aa04006e2cfd20804e33478a42
https://pubmed.ncbi.nlm.nih.gov/34250384
https://pubmed.ncbi.nlm.nih.gov/34250384
