Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Meggin Taylor"'
Autor:
Laura Lin, Mark Stahl, William S. Somers, Karen C. Carroll, Zhang-Bao Xu, Pranab K. Chanda, KeWei Wang, Karl Malakian, Robert Scannevin, Flora Jow, Meggin Taylor, Lydia Mosyak, Wade Edris, Alan H. Katz, Jennifer Megules, Stephane Olland, Kenneth J. Rhodes, Mark R. Bowlby, Weixin Xu, Qiang Lu, David C. Kopsco
Publikováno v:
Neuron. 41:587-598
The family of calcium binding proteins called KChIPs associates with Kv4 family K + channels and modulates their biophysical properties. Here, using mutagenesis and X-ray crystallography, we explore the interaction between Kv4 subunits and KChIP1. Tw
Autor:
Kristine Svenson, Kevin D. Parris, Robert M. Czerwinski, Elizabeth Federico, Scott Wolfrom, Jasbir Seehra, Jean-Baptiste Telliez, William S. Somers, Michelle Maguire, Karl Malakian, Mark Stahl, Ronald W. Kriz, Kathryn W. Underwood, Chu-Lai Hsiao, Tania Shane, Lih-Ling Lin, Meggin Taylor, Yan Liu, Lidia Mosyak
Publikováno v:
Structure. 11(6):627-636
MAP KAP kinase 2 (MK2), a Ser/Thr kinase, plays a crucial role in the inflammatory process. We have determined the crystal structures of a catalytically active C-terminal deletion form of human MK2, residues 41–364, in complex with staurosporine at
Autor:
Meggin Taylor, Robert Lowell Simmons, Amy D. Fung, Daniel A. Erlanson, Mark T. Cancilla, Nina Viswanathan, Molly M. He, Kathy Cao
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(14)
We demonstrate a fragment-based lead discovery method that combines site-directed ligand discovery with dynamic combinatorial chemistry. Our technique targets dynamic combinatorial screening to a specified region of a protein by using reversible disu