An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats

Autor: Mai Iwasaki, Arthur Lefevre, Ferdinand Althammer, Etienne Clauss Creusot, Olga Łąpieś, Hugues Petitjean, Louis Hilfiger, Damien Kerspern, Meggane Melchior, Stephanie Küppers, Quirin Krabichler, Ryan Patwell, Alan Kania, Tim Gruber, Matthew K. Kirchner, Moritz Wimmer, Henning Fröhlich, Laura Dötsch, Jonas Schimmer, Sabine C. Herpertz, Beate Ditzen, Christian P. Schaaf, Kai Schönig, Dusan Bartsch, Anna Gugula, Aleksandra Trenk, Anna Blasiak, Javier E. Stern, Pascal Darbon, Valery Grinevich, Alexandre Charlet

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

The hypothalamic neuropeptide oxytocin exerts analgesic effects, but the underlying pathways remain largely elusive. Here, the authors describe an analgesic pathway formed by oxytocin neurons projecting to the periaqueductal grey, where axonally rele

Externí odkaz: https://doaj.org/article/85fa7e14fa3741ae8af552981e58801d

Assessment of Target Engagement in a First‐in‐Human Trial with Sinbaglustat, an Iminosugar to Treat Lysosomal Storage Disorders

Autor: Martine Gehin, Meggane Melchior, Richard W.D. Welford, Patricia N. Sidharta, Jasper Dingemanse

Publikováno v: Clinical and Translational Science, Vol 14, Iss 2, Pp 558-567 (2021)

In this first‐in‐human study, the tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple oral doses of sinbaglustat, a dual inhibitor of glucosylceramide synthase (GCS) and non‐lysosomal glucosyl ceramidase (GBA2)

Externí odkaz: https://doaj.org/article/ed04fd0658df4e82b8e0c214c3adc261

Pain Behavioural Response to Acoustic and Light Environmental Changes in Very Preterm Infants

Autor: Audrey Marchal, Meggane Melchior, André Dufour, Pierrick Poisbeau, Claire Zores, Pierre Kuhn

Publikováno v: Children, Vol 8, Iss 12, p 1081 (2021)

Noise and high light illumination in the neonatal intensive care unit (NICU) are recognized as stressors that could alter the well-being and development of vulnerable preterm infants. This prospective observational study evaluated the pain behaviours

Externí odkaz: https://doaj.org/article/81717eece00b4c219bbdc7196889aaab

Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation

Autor: Clémence Gieré, Vincent Lelievre, Géraldine Gazzo, Andréa Caussaint, Meggane Melchior, Pierrick Poisbeau

Publikováno v: Brain, Behavior, and Immunity
Brain, Behavior, and Immunity, Elsevier, 2021, 92, pp.193-202. ⟨10.1016/j.bbi.2020.12.010⟩
Brain, Behavior, and Immunity, 2021, 92, pp.193-202. ⟨10.1016/j.bbi.2020.12.010⟩

International audience; Background: Early life stress is known to affect the development of the nervous system and its function at a later age. It increases the risk to develop psychiatric disorders as well as chronic pain and its associated affectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f26b64934f00f26347cbb1eb20d1ec0
https://doi.org/10.1016/j.bbi.2020.12.010

A novel analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray

Autor: Mai Iwasaki, Arthur Lefevre, Ferdinand Althammer, Olga Łąpieś, Louis Hilfiger, Damien Kerspern, Meggane Melchior, Stephanie Küppers, Quirin Krablicher, Ryan Patwell, Sabine C Herpertz, Beate Ditzen, Kai Schönig, Dusan Bartsch, Javier E. Stern, Pascal Darbon, Valery Grinevich, Alexandre Charlet

The hypothalamic neuropeptide, oxytocin (OT), exerts prominent analgesic effects via central and peripheral action. Here we discovered a novel subset of OT neurons whose projections preferentially terminate on OT receptor (OTR)-expressing neurons in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0885f09c408eca9947743e88da35a77a
https://doi.org/10.1101/2022.02.23.481531