Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Megerle L. Scherholz"'
Publikováno v:
Adv Drug Deliv Rev
Glucocorticoids influence a wide array of metabolic, anti-inflammatory, immunosuppressive, and cognitive signaling processes, playing an important role in homeostasis and preservation of normal organ function. Synthesis is regulated by the hypothalam
Publikováno v:
Mathematical Biosciences. 308:70-80
Pharmacokinetic models are particularly useful to study the underlying and complex physiological mechanisms contributing to clinical differences across patient subgroups or special populations. Unfortunately, the inherent variability of biological sy
Publikováno v:
Chronobiol Int
Endogenous glucocorticoids have diverse physiological effects and are important regulators of metabolism, immunity, cardiovascular function, musculoskeletal health and central nervous system activity. Synthetic glucocorticoids have received widesprea
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 43:481-504
Personalized medicine strives to deliver the ‘right drug at the right dose’ by considering inter-person variability, one of the causes for therapeutic failure in specialized populations of patients. Physiologically-based Pharmacokinetic (PBPK) mo
Publikováno v:
Chronobiology international. 35(12)
Natural glucocorticoids, a class of cholesterol-derived hormones, modulate an array of metabolic, anti-inflammatory, immunosuppressive and cognitive signaling. The synthesis of natural glucocorticoids, largely cortisol in humans, is regulated by the
Publikováno v:
Computerschemical engineering. 107
The use of models in biology has become particularly relevant as it enables investigators to develop a mechanistic framework for understanding the operating principles of living systems as well as in quantitatively predicting their response to both p
Autor:
Clara Hartmanshenn, Kamau Pierre, Seul-A Bae, Ioannis P. Androulakis, Rohit Rao, Megerle L. Scherholz, Alison Acevedo
Breakthroughs in high-throughput technologies have provided vast information related to the genome, transcriptome, proteome, and metabolome that enable human physiology to be described mathematically. The collection of biological data at various orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9b93e4c64f803c90602cb04708a0e6f
https://doi.org/10.1016/b978-0-444-63964-6.00001-5
https://doi.org/10.1016/b978-0-444-63964-6.00001-5
Publikováno v:
AAPS PharmSciTech. 18(2)
Early risk detection and quick diagnosis of manufacturing challenges are necessary to support the accelerated development pace of drug product in the current competitive environment. Analytical tools, such as near-infrared (NIR) chemical imaging (CI)
Autor:
Caitlin A. Boyd, Pamela L. Kubinski, Xiaoxuan Shen, Laura E. Kuczynski, Michael J. Girgis, Donald Drinkwater, Stanislaw Babiak, Sonia M. Berberena, Megerle L. Scherholz, Brian G. Lefebvre
Publikováno v:
Organic Process Research & Development. 12:1209-1217
The increasing use of metal-containing catalysts in producing pharmaceutical intermediates and active pharmaceutical ingredients, in conjunction with requirements of low metal content in a drug substance, has motivated the development of efficient se
Autor:
Wayne R. Curtis, Megerle L Scherholz
Publikováno v:
BMC Biotechnology
Background Lack of accounting for proton uptake and secretion has confounded interpretation of the stoichiometry of photosynthetic growth of algae. This is also problematic for achieving growth of microalgae to high cell concentrations which is neces