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pro vyhledávání: '"Megan Yao"'
Autor:
Kirk Clark, Andrew Paul Garner, William R. Sellers, Jing Li, Sharon Li, Rajiv Chopra, Alwin Schuller, Bruno Dombrecht, Sandra Nunes, Jennifer Johnson, Heather Huet, David R. Stover, Sanela Bilic, Megan Yao, Karen Cromie, Kris Meerschaert, Seth Ettenberg, Stephen Fawell
Publikováno v:
Cancer Research. 72:3853-3853
Preferential induction of apoptosis in cancer cells has been the objective of therapeutic strategies targeting apoptotic pathways. To this end, multiple therapeutic agonists of Death Receptors 4 and 5 (DR4, DR5), have been developed and are under cli
Autor:
Rebecca Mosher, Christopher Sean Straub, He Feng, Megan Yao, Yang Fan, Colleen Conway, Julian Chen, Dan He, Brant Firestone, John Sullivan, Stephen Fawell, Frank Stegmeier, Kymberly Levine, Dale Porter, Joanna Slisz, Tim Ramsey, Pham Ly Luu, Hui Gao, John Monahan, Michael Morrissey, Leigh Zawel, Guizhi Yang
Publikováno v:
Cancer Research. 70:138-138
Inhibitor of Apoptosis Proteins (IAP) proteins negatively regulate cell death through a variety of mechanisms. The prototypical IAP family member XIAP binds and inhibits the catalytic activity of caspases 3/7 and caspase 9 via the BIR2-linker region