Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Megan V. Michelson"'
Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice
Autor:
Patricia A. Conrad, Joseph H. Nadeau, Megan V. Michelson, Jason D. Heaney, Jennifer L. Zechel, Ericka L. Anderson, David C. Page
Publikováno v:
Development. 139:1577-1586
Testicular teratomas result from anomalies in germ cell development during embryogenesis. In the 129 family of inbred strains of mice, teratomas initiate around embryonic day (E) 13.5 during the same developmental period in which female germ cells in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5dd37340e542907f14abd5ffedbd89
https://doi.org/10.1242/dev.076851
https://doi.org/10.1242/dev.076851
Publikováno v:
Human Molecular Genetics. 18:1395-1404
The agouti-yellow (A(y)) deletion is the only genetic modifier known to suppress testicular germ cell tumor (TGCT) susceptibility in mice or humans. The A(y) mutation deletes Raly and Eif2s2, and induces the ectopic expression of agouti, all of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23916294a0188a3935271c35035f5aa
https://doi.org/10.1093/hmg/ddp045
https://doi.org/10.1093/hmg/ddp045
Publikováno v:
Cancer Research. 68:5193-5197
Several genetic variants act as modifiers of testicular germ cell tumor (TGCT) susceptibility in the 129/Sv mouse model of human pediatric TGCTs. One such modifier, the Steel locus, encodes the transmembrane-bound and soluble ligand of the kit recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51dd7b0669c093bef095cb144ea0344
https://doi.org/10.1158/0008-5472.can-08-0779
https://doi.org/10.1158/0008-5472.can-08-0779