Cardiac LXRα protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization

Autor: Megan V Cannon, Herman HW Silljé, Jürgen WA Sijbesma, Inge Vreeswijk‐Baudoin, Jolita Ciapaite, Bart van der Sluis, Jan van Deursen, Gustavo JJ Silva, Leon J de Windt, Jan‐Åke Gustafsson, Pim van der Harst, Wiek H van Gilst, Rudolf A de Boer

Publikováno v: EMBO Molecular Medicine, Vol 7, Iss 9, Pp 1229-1243 (2015)

Abstract Pathological cardiac hypertrophy is characterized by a shift in metabolic substrate utilization from fatty acids to glucose, but the molecular events underlying the metabolic remodeling remain poorly understood. Here, we investigated the rol

Externí odkaz: https://doaj.org/article/a60b17b5ab81414fab6747461a6c56fa

52 Genetic Loci Influencing Myocardial Mass

Autor: Alan F. Wright, Cisca Wijmenga, Bruno H. Stricker, Peter W. Macfarlane, Edward G. Lakatta, Uwe Völker, Lenore J. Launer, Olli T. Raitakari, Stephan B. Felix, Toshiko Tanaka, Osorio Meirelles, Phil Barnett, Thomas Meitinger, Albert Hofman, Bosco Trinh, Tamara B. Harris, Peter M. Okin, Axel Visel, Teresa Nutile, Claudia T. Silva, Harry Campbell, Ilja M. Nolte, M. Fabiola Del Greco, Terho Lehtimäki, Shih-Jen Hwang, Alicia Lundby, Kamil Slowikowski, Luigi Ferrucci, Joshua C. Bis, Jerome I. Rotter, Nona Sotoodehnia, Sebastian Schafer, Igor Rudan, Ozren Polasek, Vinicius Tragante, Kenneth Rice, Connie R. Bezzina, Siegfried Perz, Aravinda Chakravarti, Paul I.W. de Bakker, Jared W. Magnani, Xinchen Wang, Yigal M. Pinto, Carsten Oliver Schmidt, Marcus Dörr, Peter P. Pramstaller, Jobanpreet Sehmi, Susan R. Heckbert, Richard B. Devereux, Jesper V. Olsen, Sheila Ulivi, Shane Neph, Peter M. Visscher, James F. Wilson, Alexander Nord, Tim D. Spector, Stefan Kääb, Elsayed Z. Soliman, Weihua Zhang, Lin Y. Chen, Pim van der Harst, Veronique Vitart, Anna F. Dominiczak, Mark Eijgelsheim, Pieter A. Doevendans, Josef M. Penninger, Jaspal S. Kooner, Georg Vogler, Patricia B. Munroe, Soumya Raychaudhuri, Christian Gieger, Harold Snieder, Annamaria Iorio, Caroline Hayward, Yalda Jamshidi, Mika Kähönen, Jessica van Setten, Wilko Spiering, Ian Ford, Andrew A. Hicks, John C. Chambers, Joel N. Hirschhorn, Matthew T. Maurano, Niek Verweij, Maria Grazia Pilia, Rolf Bodmer, Vilmundur Gudnason, Ben A. Oostra, Megan V. Cannon, Nilesh J. Samani, Bruce H. R. Wolffenbuttel, Annette Peters, David Schlessinger, Daniel Levy, J. Wouter Jukema, Malou van den Boogaard, Brendan M. Buckley, Arne Pfeufer, Michiel E. Adriaens, Rossella Sorice, Matthias Heinig, Jian Yang, Norbert Hubner, Stefania Bandinelli, André G. Uitterlinden, Hans L. Hillege, Martina Müller-Nurasyid, Andres Metspalu, Eric Haugen, Laurie A. Boyer, Ronald P. Stolk, Gonçalo R. Abecasis, Dan E. Arking, Manolis Kellis, Ishminder K. Kooner, Leo-Pekka Lyytikäinen, Dena G. Hernandez, Dirk J. van Veldhuisen, Len A. Pennacchio, Kasper Lage, Gianfranco Sinagra, Bruce M. Psaty, Christopher Newton-Cheh, Cornelia M. van Duijn, Stefania Nappo, Dalit May, Paolo Gasparini, Elizabeth J. Rossin, Rudolf A. de Boer, Alessandro P Delitala, Tõnu Esko, John A. Stamatoyannopoulos, Aaron Isaacs, Kathleen F. Kerr, Sian Tsung Tan, Tune H. Pers, Serena Sanna, Melanie Waldenberger, Marina Ciullo, Jorma Viikari, Vincent M. Christoffels, Bram P. Prins, Alvaro Alonso, Sandosh Padmanabhan, Harm-Jan Westra, Moritz F. Sinner, Albert V. Smith, Kirill V. Tarasov, Konstantin Strauch, Wiek H. van Gilst, Christian X. Weichenberger, Lude Franke, Folkert W. Asselbergs, Herman H W Silljé, Jan A. Kors, Irene Mateo Leach, Karl Andersen, Ivana Kolcic, Stella Trompet, Silvia Naitza

Publikováno v: Elsevier
Journal of the American College of Cardiology, 68(13), 1435-1448. Elsevier Science
Journal of The American College of Cardiology
Journal of the American College of Cardiology, 68(13), 1435. Elsevier USA
van der Harst, P, van Setten, J, Verweij, N, Vogler, G, Franke, L, Maurano, M T, Wang, X, Mateo Leach, I, Eijgelsheim, M, Sotoodehnia, N, Hayward, C, Sorice, R, Meirelles, O, Lyytikäinen, L-P, Polašek, O, Tanaka, T, Arking, D E, Ulivi, S, Trompet, S, Müller-Nurasyid, M, Smith, A V, Dörr, M, Kerr, K F, Magnani, J W, Del Greco M, F, Zhang, W, Nolte, I M, Silva, C T, Padmanabhan, S, Tragante, V, Esko, T, Abecasis, G R, Adriaens, M E, Andersen, K, Barnett, P, Bis, J C, Bodmer, R, Buckley, B M, Campbell, H, Cannon, M V, Chakravarti, A, Chen, L Y, Delitala, A, Devereux, R B, Doevendans, P A, Dominiczak, A F, Ferrucci, L, Ford, I, Gieger, C, Harris, T B, Haugen, E, Heinig, M, Hernandez, D G, Hillege, H L, Hirschhorn, J N, Hofman, A, Hubner, N, Hwang, S-J, Iorio, A, Kähönen, M, Kellis, M, Kolcic, I, Kooner, I K, Kooner, J S, Kors, J A, Lakatta, E G, Lage, K, Launer, L J, Levy, D, Lundby, A, Macfarlane, P W, May, D, Meitinger, T, Metspalu, A, Nappo, S, Naitza, S, Neph, S, Nord, A S, Nutile, T, Okin, P M, Olsen, J V, Oostra, B A, Penninger, J M, Pennacchio, L A, Pers, T H, Perz, S, Peters, A, Pinto, Y M, Pfeufer, A, Pilia, M G, Pramstaller, P P, Prins, B P, Raitakari, O T, Raychaudhuri, S, Rice, K M, Rossin, E J, Rotter, J I, Schafer, S, Schlessinger, D, Schmidt, C O, Sehmi, J, Silljé, H H W, Sinagra, G, Sinner, M F, Slowikowski, K, Soliman, E Z, Spector, T D, Spiering, W, Stamatoyannopoulos, J A, Stolk, R P, Strauch, K, Tan, S-T, Tarasov, K V, Trinh, B, Uitterlinden, A G, van den Boogaard, M, van Duijn, C M, van Gilst, W H, Viikari, J S, Visscher, P M, Vitart, V, Völker, U, Waldenberger, M, Weichenberger, C X, Westra, H-J, Wijmenga, C, Wolffenbuttel, B H, Yang, J, Bezzina, C R, Munroe, P B, Snieder, H, Wright, A F, Rudan, I, Boyer, L A, Asselbergs, F W, van Veldhuisen, D J, Stricker, B H, Psaty, B M, Ciullo, M, Sanna, S, Lehtimäki, T, Wilson, J F, Bandinelli, S, Alonso, A, Gasparini, P, Jukema, J W, Kääb, S, Gudnason, V, Felix, S B, Heckbert, S R, de Boer, R A, Newton-Cheh, C, Hicks, A A, Chambers, J C, Jamshidi, Y, Visel, A, Christoffels, V M, Isaacs, A, Samani, N J & de Bakker, P I W 2016, ' 52 Genetic Loci Influencing Myocardial Mass ', Journal of the American College of Cardiology, vol. 68, no. 13, pp. 1435-1448 . https://doi.org/10.1016/j.jacc.2016.07.729
Journal of the American College of Cardiology
68 (2016): 1435–1448. doi:10.1016/j.jacc.2016.07.729
info:cnr-pdr/source/autori:van der Harst, Pim; van Setten, Jessica; Verweij, Niek; Vogler, Georg; Franke, Lude; Maurano, Matthew T.; Wang, Xinchen; Leach, Irene Mateo; Eijgelsheim, Mark; Sotoodehnia, Nona; Hayward, Caroline; Sorice, Rossella; Meirelles, Osorio; Lyytikainen, Leo-Pekka; Polasek, Ozren; Tanaka, Toshiko; Arking, Dan E.; Ulivi, Sheila; Trompet, Stella; Mueller-Nurasyid, Martina; Smith, Albert V.; Doerr, Marcus; Kerr, Kathleen F.; Magnani, Jared W.; Del Greco, Fabiola; Zhang, Weihua; Nolte, Ilja M.; Silva, Claudia T.; Padmanabhan, Sandosh; Tragante, Vinicius; Esko, Tonu; Abecasis, Gonclo R.; Adriaens, Michiel E.; Andersen, Karl; Barnett, Phil; Bis, Joshua C.; Bodmer, Rolf; Buckley, Brendan M.; Campbell, Harry; Cannon, Megan V.; Chakravarti, Aravinda; Chen, Lin Y.; Delitala, Alessandro; Devereux, Richard B.; Doevendans, Pieter A.; Dominiczak, Anna F.; Ferrucci, Luigi; Ford, Ian; Gieger, Christian; Harris, Tamara B.; Haugen, Eric; Heinig, Matthias; Hernandez, Dena G.; Hillege, Hans L.; Hirschhorn, Joel N.; Hofman, Albert; Hubner, Norbert; Hwang, Shih-Jen; Iorio, Annamaria; Kahonen, Mika; Kellis, Manolis; Kolcic, Ivana; Kooner, Ishminder K.; Kooner, Jaspal S.; Kors, Jan A.; Lakatta, Edward G.; Lage, Kasper; Launer, Lenore J.; Levy, Daniel; Lundby, Alicia; Macfarlane, Peter W.; May, Dalit; Meitinger, Thomas; Metspalu, Andres; Nappo, Stefania; Naitza, Silvia; Neph, Shane; Nord, Alex S.; Nutile, Teresa; Okin, Peter M.; Olsen, Jesper V.; Oostra, Ben A.; Penninger, Josef M.; Pennacchio, Len A.; Pers, Tune H.; Perz, Siegfried; Peters, Annette; Pinto, Yigal M.; Pfeufer, Arne; Pilia, Maria Grazia; Pramstaller, Peter P.; Prins, Bram P.; Raitakari, Olli T.; Raychaudhuri, Soumya; Rice, Ken M.; Rossin, Elizabeth J.; Rotter, Jerome I.; Schafer, Sebastian; Schlessinger, David; Schmidt, Carsten O.; Sehmi, Jobanpreet; Sillje, Herman H. W.; Sinagra, Gianfranco; Sinner, Moritz F.; Slowikowski, Kamil; Soliman, Elsayed Z.; Spector, Timothy D.; Spiering, Wilko; Stamatoyannopoulos, John A.; Stolk, Ronald P.; Strauch, Konstantin; Tan, Sian-Tsung; Tarasov, Kirill V.; Trinh, Bosco; Uitterlinden, Andre G.; van den Boogaard, Malou; van Duijn, Cornelia M.; van Gilst, Wiek H.; Viikari, Jorma S.; Visscher, Peter M.; Vitart, Veronique; Voelker, Uwe; Waldenberger, Melanie; Weichenberger, Christian X.; Westra, Harm-Jan; Wijmenga, Cisca; Wolffenbuttel, Bruce H.; Yang, Jian; Bezzina, Connie R.; Munroe, Patricia B.; Snieder, Harold; Wright, Alan F.; Rudan, Igor; Boyer, Laurie A.; Asselbergs, Folkert W.; van Veldhuisen, Dirk J.; Stricker, Bruno H.; Psaty, Bruce M.; Ciullo, Marina; Sanna, Serena; Lehtimaki, Terho; Wilson, James F.; Bandinelli, Stefania; Alonso, Alvaro; Gasparini, Paolo; Jukema, J. Wouter; Kaeaeb, Stefan; Gudnason, Vilmundur; Felix, Stephan B.; Heckbert, Susan R.; de Boer, Rudolf A.; Newton-Cheh, Christopher; Hicks, Andrew A.; Chambers, John C.; Jamshidi, Yalda; Visel, Axel; Christoffels, Vincent M.; Isaacs, Aaron; Samani, Nilesh J.; de Bakker, Paul I. W./titolo:52 Genetic Loci Influencing Myocardial Mass/doi:10.1016%2Fj.jacc.2016.07.729/rivista:Journal of the American College of Cardiology (Print)/anno:2016/pagina_da:1435/pagina_a:1448/intervallo_pagine:1435–1448/volume:68
Journal of the American College of Cardiology, 68(13), 1435-1448
van der Harst, P, van Setten, J, Verweij, N, Vogler, G, Franke, L, Maurano, M T, Wang, X, Mateo Leach, I, Eijgelsheim, M, Sotoodehnia, N, Hayward, C, Sorice, R, Meirelles, O, Lyytikäinen, L-P, Polašek, O, Tanaka, T, Arking, D E, Ulivi, S, Trompet, S, Müller-Nurasyid, M, Smith, A V, Dörr, M, Kerr, K F, Magnani, J W, Del Greco M, F, Zhang, W, Nolte, I M, Silva, C T, Padmanabhan, S, Tragante, V, Esko, T, Abecasis, G R, Adriaens, M E, Andersen, K, Barnett, P, Bis, J C, Bodmer, R, Buckley, B M, Campbell, H, Cannon, M V, Chakravarti, A, Chen, L Y, Delitala, A, Devereux, R B, Doevendans, P A, Dominiczak, A F, Ferrucci, L, Ford, I, Gieger, C, Harris, T B, Haugen, E, Heinig, M, Hernandez, D G, Hillege, H L, Hirschhorn, J N, Hofman, A, Hubner, N, Hwang, S-J, Iorio, A, Kähönen, M, Kellis, M, Kolcic, I, Kooner, I K, Kooner, J S, Kors, J A, Lakatta, E G, Lage, K, Launer, L J, Levy, D, Lundby, A, Macfarlane, P W, May, D, Meitinger, T, Metspalu, A, Nappo, S, Naitza, S, Neph, S, Nord, A S, Nutile, T, Okin, P M, Olsen, J V, Oostra, B A, Penninger, J M, Pennacchio, L A, Pers, T H, Perz, S, Peters, A, Pinto, Y M, Pfeufer, A, Pilia, M G, Pramstaller, P P, Prins, B P, Raitakari, O T, Raychaudhuri, S, Rice, K M, Rossin, E J, Rotter, J I, Schafer, S, Schlessinger, D, Schmidt, C O, Sehmi, J, Silljé, H H W, Sinagra, G, Sinner, M F, Slowikowski, K, Soliman, E Z, Spector, T D, Spiering, W, Stamatoyannopoulos, J A, Stolk, R P, Strauch, K, Tan, S-T, Tarasov, K V, Trinh, B, Uitterlinden, A G, van den Boogaard, M, van Duijn, C M, van Gilst, W H, Viikari, J S, Visscher, P M, Vitart, V, Völker, U, Waldenberger, M, Weichenberger, C X, Westra, H-J, Wijmenga, C, Wolffenbuttel, B H, Yang, J, Bezzina, C R, Munroe, P B, Snieder, H, Wright, A F, Rudan, I, Boyer, L A, Asselbergs, F W, van Veldhuisen, D J, Stricker, B H, Psaty, B M, Ciullo, M, Sanna, S, Lehtimäki, T, Wilson, J F, Bandinelli, S, Alonso, A, Gasparini, P, Jukema, J W, Kääb, S, Gudnason, V, Felix, S B, Heckbert, S R, de Boer, R A, Newton-Cheh, C, Hicks, A A, Chambers, J C, Jamshidi, Y, Visel, A, Christoffels, V M, Isaacs, A, Samani, N J & de Bakker, P I W 2016, ' 52 Genetic Loci Influencing Myocardial Mass ', Journal of the American College of Cardiology, vol. 68, no. 13, pp. 1435-48 . https://doi.org/10.1016/j.jacc.2016.07.729
Journal of the American College of Cardiology, 68(13), 1435-1448. Elsevier USA
Journal of the American College of Cardiology, 68(13), 1435-1448. Elsevier Inc.
Journal of the American College of Cardiology, 68(13), 1435-1448. ELSEVIER SCIENCE INC
J. Am. Coll. Cardiol. 68, 1435-1448 (2016)
van der Harst, P, van Setten, J, Verweij, N, Vogler, G, Franke, L, Maurano, M T, Wang, X, Mateo Leach, I, Eijgelsheim, M, Sotoodehnia, N, Hayward, C, Sorice, R, Meirelles, O, Lyytikäinen, L-P, Polasek, O, Tanaka, T, Arking, D E, Ulivi, S, Trompet, S, Müller-Nurasyid, M, Smith, A V, Dörr, M, Kerr, K F, Magnani, J W, Del Greco M, F, Zhang, W, Nolte, I M, Silva, C T, Padmanabhan, S, Tragante, V, Esko, T, Abecasis, G R, Adriaens, M E, Andersen, K, Barnett, P, Bis, J C, Bodmer, R, Buckley, B M, Campbell, H, Cannon, M V, Chakravarti, A, Chen, L Y, Delitala, A, Devereux, R B, Doevendans, P A, Dominiczak, A F, Ferrucci, L, Ford, I, Gieger, C, Harris, T B, Haugen, E, Heinig, M, Hernandez, D G, Hillege, H L, Hirschhorn, J N, Hofman, A, Hubner, N, Hwang, S-J, Iorio, A, Kähönen, M, Kellis, M, Kolcic, I, Kooner, I K, Kooner, J S, Kors, J A, Lakatta, E G, Lage, K, Launer, L J, Levy, D, Lundby, A, Macfarlane, P W, May, D, Meitinger, T, Metspalu, A, Nappo, S, Naitza, S, Neph, S, Nord, A S, Nutile, T, Okin, P M, Olsen, J V, Oostra, B A, Penninger, J M, Pennacchio, L A, Pers, T H, Perz, S, Peters, A, Pinto, Y M, Pfeufer, A, Pilia, M G, Pramstaller, P P, Prins, B P, Raitakari, O T, Raychaudhuri, S, Rice, K M, Rossin, E J, Rotter, J I, Schafer, S, Schlessinger, D, Schmidt, C O, Sehmi, J, Silljé, H H W, Sinagra, G, Sinner, M F, Slowikowski, K, Soliman, E Z, Spector, T D, Spiering, W, Stamatoyannopoulos, J A, Stolk, R P, Strauch, K, Tan, S-T, Tarasov, K V, Trinh, B, Uitterlinden, A G, van den Boogaard, M, van Duijn, C M, van Gilst, W H, Viikari, J S, Visscher, P M, Vitart, V, Völker, U, Waldenberger, M, Weichenberger, C X, Westra, H-J, Wijmenga, C, Wolffenbuttel, B H, Yang, J, Bezzina, C R, Munroe, P B, Snieder, H, Wright, A F, Rudan, I, Boyer, L A, Asselbergs, F W, van Veldhuisen, D J, Stricker, B H, Psaty, B M, Ciullo, M, Sanna, S, Lehtimäki, T, Wilson, J F, Bandinelli, S, Alonso, A, Gasparini, P, Jukema, J W, Kääb, S, Gudnason, V, Felix, S B, Heckbert, S R, de Boer, R A, Newton-Cheh, C, Hicks, A A, Chambers, J C, Jamshidi, Y, Visel, A, Christoffels, V M, Isaacs, A, Samani, N J & de Bakker, P I W 2016, ' 52 Genetic Loci Influencing Myocardial Mass ', Journal of the American College of Cardiology, vol. 68, no. 13, pp. 1435-48 . https://doi.org/10.1016/j.jacc.2016.07.729
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario

BACKGROUND Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db2fc7f0a4c18983fe62e1ec6c7ffd5
https://doi.org/10.1016/j.jacc.2016.07.729

The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects

Autor: Wiek H. van Gilst, Hongjuan Yu, Martin M Dokter, Rudolf A. de Boer, Herman H W Silljé, Megan V. Cannon, Wellington M Candido, Eva-Lotte Lindstedt

Publikováno v: European Journal of Heart Failure. 17:273-282

AimsLiver X receptors (LXRs) transcriptionally regulate inflammation, metabolism, and immunity. Synthetic LXR agonists have been evaluated for their efficacy in the cardiovascular system; however, they elicit prolipogenic side effects which substanti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46fd8488ce403ea204dec87cd0cda7f6
https://doi.org/10.1002/ejhf.243

Emerging role of liver X receptors in cardiac pathophysiology and heart failure

Autor: Wiek H. van Gilst, Rudolf A. de Boer, Megan V. Cannon

Publikováno v: Basic Research in Cardiology

Liver X receptors (LXRs) are master regulators of metabolism and have been studied for their pharmacological potential in vascular and metabolic disease. Besides their established role in metabolic homeostasis and disease, there is mounting evidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fd9701609176728262094634432472
https://doi.org/10.1007/s00395-015-0520-7

The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects

Autor: Megan V, Cannon, Hongjuan, Yu, Wellington M, Candido, Martin M, Dokter, Eva-Lotte, Lindstedt, Herman H W, Silljé, Wiek H, van Gilst, Rudolf A, de Boer

Publikováno v: European journal of heart failure. 17(3)

Liver X receptors (LXRs) transcriptionally regulate inflammation, metabolism, and immunity. Synthetic LXR agonists have been evaluated for their efficacy in the cardiovascular system; however, they elicit prolipogenic side effects which substantially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b61b0952d775670882a4c7fc74ec7964
https://pubmed.ncbi.nlm.nih.gov/25684370