Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Megan Tomlin"'
Autor:
Ratnakar Singh, Zeeshan Fazal, Emmanuel Bikorimana, Raya I. Boyd, Cliff Yerby, Megan Tomlin, Hannah Baldwin, Doha Shokry, Andrea K. Corbet, Khadeeja Shahid, Aleyah Hattab, Sarah J. Freemantle, Michael J. Spinella
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 683-698 (2022)
Testicular germ cell tumors (TGCTs) are aggressive but sensitive to cisplatin‐based chemotherapy. Alternative therapies are needed for tumors refractory to cisplatin with hypomethylating agents providing one possibility. The mechanisms of cisplatin
Externí odkaz:
https://doaj.org/article/1996a69b2850475d84e180ad54ed68ef
Autor:
Zeeshan Fazal, Ratnakar Singh, Fang Fang, Emmanuel Bikorimana, Hannah Baldwin, Andrea Corbet, Megan Tomlin, Cliff Yerby, Nabil Adra, Costantine Albany, Sarah Lee, Sarah J. Freemantle, Kenneth P Nephew, Brock C Christensen, Michael J. Spinella
Publikováno v:
Epigenetics, Vol 16, Iss 10, Pp 1071-1084 (2021)
Testicular germ cell tumours (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift towards DNA hypermethylation mediates cisplatin resistance in TGCT cells, altho
Externí odkaz:
https://doaj.org/article/4b7b7223caa54e218dd20f2ec7342e9a
Autor:
Sarah J. Freemantle, Megan Tomlin, Khadeeja Shahid, Andrea K. Corbet, Aleyah Hattab, Emmanuel Bikorimana, Hannah Baldwin, Raya I. Boyd, Ratnakar Singh, Cliff Yerby, Doha Shokry, Zeeshan Fazal, Michael J. Spinella
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 683-698 (2022)
Molecular Oncology
Molecular Oncology
Testicular germ cell tumors (TGCTs) are aggressive but sensitive to cisplatin‐based chemotherapy. Alternative therapies are needed for tumors refractory to cisplatin with hypomethylating agents providing one possibility. The mechanisms of cisplatin
Autor:
Sarah J. Freemantle, Sarah Lee, Fang Fang, Kenneth P. Nephew, Emmanuel Bikorimana, Ratnakar Singh, Hannah Baldwin, Cliff Yerby, Megan Tomlin, Michael J. Spinella, Brock C. Christensen, Andrea K. Corbet, Zeeshan Fazal, Costantine Albany, Nabil Adra
Publikováno v:
Epigenetics
Testicular germ cell tumours (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift towards DNA hypermethylation mediates cisplatin resistance in TGCT cells, altho
Autor:
Doha Shokry, Michael J. Spinella, Sarah Joy Spinella, Megan Tomlin, Aleyah Hattab, Zeeshan Fazal, Ratnakar Singh
Publikováno v:
Cancer Research. 81:2096-2096
Acquired resistance to chemotherapy is perhaps the major barrier to cure of advanced cancers. Testicular germ cell tumors (TGCTs) are the most common cancers of young males. TGCTs are one of the few solid tumors that are cured at a high rate with sta
Autor:
Michael J. Spinella, Khadeeja Shahid, Sarah Joy Spinella, Raya I. Boyd, Andrea K. Corbet, Cliff Yerby, Megan Tomlin, Doha Shokry, Hannah Baldwin, Emmanuel Bikorimana, Aleyah Hattab, Ratnakar Singh, Zeeshan Fazal
Publikováno v:
Cancer Research. 81:2127-2127
Testicular germ cell tumors (TGCTs) are the most frequent solid cancers of males between the ages of 16 to 39 and have the highest mortality in this age group. Testicular cancer is highly curable with platinum-based chemotherapeutics. However, 15-20%