Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Megan Stringer"'
Autor:
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106359- (2024)
Aberrant neurodevelopment in Down syndrome (DS)—caused by triplication of human chromosome 21—is commonly attributed to gene dosage imbalance, linking overexpression of trisomic genes with disrupted developmental processes, with DYRK1A particular
Externí odkaz:
https://doaj.org/article/498ceb1ba95143fe980dbcdcee3b112b
Publikováno v:
Pharmacol Biochem Behav
The neurotypical spatiotemporal patterns of gene expression are disrupted in Down syndrome (DS) by trisomy of human chromosome 21 (Hsa21), resulting in altered behavioral development and brain circuitry. The Ts65Dn DS mouse model exhibits similar phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e0c1790489d1811086eb04e7a4a654
https://europepmc.org/articles/PMC9516663/
https://europepmc.org/articles/PMC9516663/
Autor:
Megan Stringer, Lauren Wingo, Michael Gryniuk, Frances Yang, Mark D. Webster, Dirk M. Kestner, Luke Lombardi
Publikováno v:
IABSE Congress Reports.
Achieving reductions to embodied carbon, the global warming potential emissions due to the production of materials, is an essential component to meeting science-based climate targets. Studies have shown that a significant portion of embodied emission
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d5bc4a4a5697ffc393f31dfbd6e4ba4
https://doi.org/10.2749/ghent.2021.0224
https://doi.org/10.2749/ghent.2021.0224
Autor:
Charles R. Goodlett, Megan Stringer, Roshni Patel, Randall J. Roper, Jonathan LaCombe, Joseph M. Wallace
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Epigallocatechin-3-gallate (EGCG) is a candidate therapeutic for Down syndrome (DS) phenotypes based on in vitro inhibition of DYRK1A, a triplicated gene product of Trisomy 21 (Ts21). Consumption of green tea extracts containing EGCG improved some co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c644096d4bc0e546f566c1d590ff301f
https://doi.org/10.1038/s41598-020-67133-z
https://doi.org/10.1038/s41598-020-67133-z
Publikováno v:
Molecular Genetics & Genomic Medicine
Overexpression of Dual‐specificity tyrosine‐phosphorylated regulated kinase 1A (DYRK1A), located on human chromosome 21, may alter molecular processes linked to developmental deficits in Down syndrome (DS). Trisomic DYRK1A is a rational therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92a73b73d0e45f356a75c0ae75cd98a
http://europepmc.org/articles/PMC5606891
http://europepmc.org/articles/PMC5606891
Autor:
Jonathan LaCombe, Karl J. Dria, Charles R. Goodlett, Kailey Stancombe, Megan Stringer, Jared Thomas, Randall J. Roper, Irushi Abeysekera, Joseph M. Wallace, Robert J. Stewart
Publikováno v:
Physiology & Behavior. 177:230-241
Down syndrome (DS) is caused by three copies of human chromosome 21 (Hsa21) and results in phenotypes including intellectual disability and skeletal deficits. Ts65Dn mice have three copies of ~50% of the genes homologous to Hsa21 and display phenotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf53fec916b6aa7150da37590357a3b
https://doi.org/10.1016/j.physbeh.2017.05.003
https://doi.org/10.1016/j.physbeh.2017.05.003
Publikováno v:
Pharmacology Biochemistry and Behavior. 138:70-79
Down syndrome (DS) or Trisomy 21 causes intellectual disabilities in humans and the Ts65Dn DS mouse model is deficient in learning and memory tasks. DYRK1A is triplicated in DS and Ts65Dn mice. Ts65Dn mice were given up to ~20mg/kg/day epigallocatech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1bb5598bf937c0994f1034c9ca5450
https://doi.org/10.1016/j.pbb.2015.09.002
https://doi.org/10.1016/j.pbb.2015.09.002
Autor:
Megan Stringer, David W. Fowler, Taylor Crawford, David P Whitney, Moon C Won, Dar Hao Chen, James O. Jirsa
Publikováno v:
New Technologies in Construction and Rehabilitation of Portland Cement Concrete Pavement and Bridge Deck Pavement.
Longitudinal cracking and longitudinal joint separations are commonly observed distresses in concrete pavements. The Texas Department of Transportation instituted a research project to determine the causes and to recommend repair methods. Repair meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7798004244903ec53f2767b829800a7
https://doi.org/10.1061/41048(355)15
https://doi.org/10.1061/41048(355)15