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pro vyhledávání: '"Megan Siemann"'
Autor:
Abdel Nasser Hosein, Gita Dangol, Takashi Okumura, Jason Roszik, Kimal Rajapakshe, Megan Siemann, Mohamed Zaid, Bidyut Ghosh, Maria Monberg, Paola A. Guerrero, Aatur Singhi, Cara L. Haymaker, Hans Clevers, Lotfi Abou-Elkacem, Sonja M. Woermann, Anirban Maitra
Publikováno v:
Gastroenterology
Gastroenterology. W.B. Saunders Ltd
Gastroenterology. W.B. Saunders Ltd
BACKGROUND: RNF43 is an E3 ubiquitin ligase that is recurrently mutated in pancreatic ductal adenocarcinoma (PDAC) and precursor cystic neoplasms of the pancreas. The impact of RNF43 mutations on PDAC is poorly understood and autochthonous models hav