Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Megan S. Utter"'
Autor:
Marcus Henze, R. John Solaro, Michelle M. Monasky, Chad M. Warren, Domenico M. Taglieri, Jonathan D. Violin, David G. Soergel, Megan S. Utter
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 305:H856-H866
In the present study, we compared the cardioprotective effects of TRV120023, a novel angiotensin II (ANG II) type 1 receptor (AT1R) ligand, which blocks G protein coupling but stimulates β-arrestin signaling, against treatment with losartan, a conve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b2858ea743acc3099ae54d8c93a99d
https://doi.org/10.1152/ajpheart.00327.2013
https://doi.org/10.1152/ajpheart.00327.2013
Apart from transplant, there are no satisfactory therapies for the severe depression in contractility in familial dilated cardiomyopathy (DCM). Current heart failure treatments that act by increasing contractility involve signaling cascades that alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2309b1e3d2d3f1f579e3e24c265c8c
https://europepmc.org/articles/PMC5460532/
https://europepmc.org/articles/PMC5460532/
Publikováno v:
Physiological Reports
Although high fidelity measurements of posttranslational modifications (PTMs) of cardiac myofilament proteins exist, important issues remain regarding basic techniques of sample acquisition and storage. We investigated the effects of anesthetic regim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100a0ca0059d3266635045073ea109fa
https://pubmed.ncbi.nlm.nih.gov/25952935
https://pubmed.ncbi.nlm.nih.gov/25952935
Autor:
Shamim A. K. Chowdhury, Megan S. Utter, Jillian N. Simon, R. John Solaro, Yunbo Ke, Manuel G. Alvarez, Beata M. Wolska, Robert T. Davis, Ahlke Heydemann, Paul Mungai
Publikováno v:
Cardiovascular research. 108(3)
Aims Despite its known cardiovascular benefits, the intracellular signalling mechanisms underlying physiological cardiac growth remain poorly understood. Therefore, the purpose of this study was to investigate a novel role of p21-activated kinase-1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614e97a4b5d659221a974d02c185ce91
https://pubmed.ncbi.nlm.nih.gov/26464331
https://pubmed.ncbi.nlm.nih.gov/26464331
Autor:
R. John Solaro, Aldrin V. Gomes, Jose L. Puglisi, Donald M. Bers, Megan S. Utter, Paul H. Goldspink
Chronic increases in myofilament Ca(2+)-sensitivity in the heart are known to alter gene expression potentially modifying Ca(2+)-homeostasis and inducing arrhythmias. We tested age-dependent effects of a chronic increase in myofilament Ca(2+)-sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7467def206bb37939b57e94493e923
https://escholarship.org/uc/item/3qd4q0dv
https://escholarship.org/uc/item/3qd4q0dv
Autor:
Aaron C. Hinken, Chad M. Warren, R. John Solaro, Fernando Augusto Lavezzo Dias, David F. Wieczorek, Megan S. Utter, Brandon J. Biesiadecki, Eric M. Montminy, Sakthivel Sadayappan, Beata M. Wolska, Jillian N. Simon, Robert D. Gaffin, Marco S.L. Alves, rd Robert T. Davis, Jeffrey Robbins
Publikováno v:
Circulation. Cardiovascular genetics. 7(2)
Background— Hypertrophic cardiomyopathy (HCM) is a common genetic disorder caused mainly by mutations in sarcomeric proteins and is characterized by maladaptive myocardial hypertrophy, diastolic heart failure, increased myofilament Ca 2+ sensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf59e3aa0ae082292113101997c8aca9
https://pubmed.ncbi.nlm.nih.gov/24585742
https://pubmed.ncbi.nlm.nih.gov/24585742