Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Megan S. Saari"'
1
Molecular basis of polycomb group protein-mediated fetal hemoglobin repression
Autor: Kunhua Qin, Xianjiang Lan, Peng Huang, Megan S. Saari, Eugene Khandros, Cheryl A Keller, Belinda M. Giardine, Osheiza Abdulmalik, Junwei Shi, Ross C. Hardison, Gerd A. Blobel
Publikováno v: Blood.
The fetal (HbF)-to-adult (HbA) hemoglobin switch is a paradigm for developmental gene expression control with relevance to sickle cell disease and b-thalassemia. Polycomb repressive complex (PRC) proteins regulate this switch, and an inhibitor of PRC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2836ffab659abb0f4353fd99a0d730d4
https://doi.org/10.1182/blood.2022019578
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5
Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression
Autor: Aoi Wakabayashi, Maryanne Kihiu, Malini Sharma, A. Josephine Thrasher, Megan S. Saari, Mathieu Quesnel-Vallières, Osheiza Abdulmalik, Scott A. Peslak, Eugene Khandros, Cheryl A. Keller, Belinda M. Giardine, Yoseph Barash, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
Publikováno v: Blood advances. 6(23)
The fetal-to-adult hemoglobin transition is clinically relevant because reactivation of fetal hemoglobin (HbF) significantly reduces morbidity and mortality associated with sickle cell disease (SCD) and β-thalassemia. Most studies on the development
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28be025594677320dfead8f98b4f5ac6
https://pubmed.ncbi.nlm.nih.gov/35622975
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6
Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells
Autor: Kunhua, Qin, Peng, Huang, Ruopeng, Feng, Cheryl A, Keller, Scott A, Peslak, Eugene, Khandros, Megan S, Saari, Xianjiang, Lan, Thiyagaraj, Mayuranathan, Phillip A, Doerfler, Osheiza, Abdulmalik, Belinda, Giardine, Stella T, Chou, Junwei, Shi, Ross C, Hardison, Mitchell J, Weiss, Gerd A, Blobel
Publikováno v: Nature genetics. 54(6)
The mechanisms by which the fetal-type β-globin-like genes HBG1 and HBG2 are silenced in adult erythroid precursor cells remain a fundamental question in human biology and have therapeutic relevance to sickle cell disease and β-thalassemia. Here, w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d2d0df83c38bbeb7158427e90ed8d07
https://pubmed.ncbi.nlm.nih.gov/35650318
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