Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Megan R. Showalter"'
Autor:
Jun Ding, Jian Ji, Zachary Rabow, Tong Shen, Jacob Folz, Christopher R. Brydges, Sili Fan, Xinchen Lu, Sajjan Mehta, Megan R. Showalter, Ying Zhang, Renee Araiza, Lynette R. Bower, K. C. Kent Lloyd, Oliver Fiehn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Metabolites play an important role in physiology, yet the complexity of the metabolome and its interaction with disease and aging is poorly understood. Here the authors present a comprehensive atlas of the mouse brain metabolome and how it changes du
Externí odkaz:
https://doaj.org/article/a2f3452ce44b41c2919934ac9e218480
Autor:
Shu‐Yi Liao, Angela Linderholm, Megan R. Showalter, Ching‐Hsien Chen, Oliver Fiehn, Nicholas J. Kenyon
Publikováno v:
Obesity Science & Practice, Vol 7, Iss 3, Pp 339-345 (2021)
Abstract Obesity is considered as a risk factor for COVID‐19 with insulin resistance and increased production of inflammatory cytokines as likely mechanisms. Glucagon‐like peptide‐1 (GLP‐1) agonists and inhaled nitric oxide are proposed thera
Externí odkaz:
https://doaj.org/article/a9b55b491dba4b498dbdbaac8960bee9
Autor:
Jason W. Miklas, Elisa Clark, Shiri Levy, Damien Detraux, Andrea Leonard, Kevin Beussman, Megan R. Showalter, Alec T. Smith, Peter Hofsteen, Xiulan Yang, Jesse Macadangdang, Tuula Manninen, Daniel Raftery, Anup Madan, Anu Suomalainen, Deok-Ho Kim, Charles E. Murry, Oliver Fiehn, Nathan J. Sniadecki, Yuliang Wang, Hannele Ruohola-Baker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
Mutations in the gene HADHA result in mitochondrial tri-functional protein (MTP) deficiency and can result in sudden infant death syndrome for which there is no treatment. Here the authors show that the MTP deficient pathology in human cardiomyocytes
Externí odkaz:
https://doaj.org/article/eb9585b9475b4ec39e5021a1cc4c96fb
Autor:
Lan N. Tu, Megan R. Showalter, Tomas Cajka, Sili Fan, Viju V. Pillai, Oliver Fiehn, Vimal Selvaraj
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Nonalcoholic fatty liver disease (NAFLD) in non-obese patients remains a clinical condition with unclear etiology and pathogenesis. Using a metabolomics approach in a mouse model that recapitulates almost all the characteristic features of n
Externí odkaz:
https://doaj.org/article/273c2e5360d44f8d90ee63f1a2c4e581
Autor:
Jason W. Miklas, Elisa Clark, Shiri Levy, Damien Detraux, Andrea Leonard, Kevin Beussman, Megan R. Showalter, Alec T. Smith, Peter Hofsteen, Xiulan Yang, Jesse Macadangdang, Tuula Manninen, Daniel Raftery, Anup Madan, Anu Suomalainen, Deok-Ho Kim, Charles E. Murry, Oliver Fiehn, Nathan J. Sniadecki, Yuliang Wang, Hannele Ruohola-Baker
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/f7095833820746779a08b9bceffb7aec
Publikováno v:
Metabolites, Vol 10, Iss 1, p 25 (2020)
The authors wish to make the following correction to this paper [...]
Externí odkaz:
https://doaj.org/article/4b4a1768b6b647db80258eda9b3d3821
Autor:
Dinesh K. Barupal, Ying Zhang, Tong Shen, Sili Fan, Bryan S. Roberts, Patrick Fitzgerald, Benjamin Wancewicz, Luis Valdiviez, Gert Wohlgemuth, Gregory Byram, Ying Yng Choy, Bennett Haffner, Megan R. Showalter, Arpana Vaniya, Clayton S. Bloszies, Jacob S. Folz, Tobias Kind, Ann M. Flenniken, Colin McKerlie, Lauryl M. J. Nutter, Kent C. Lloyd, Oliver Fiehn
Publikováno v:
Metabolites, Vol 9, Iss 5, p 101 (2019)
Mouse knockouts facilitate the study ofgene functions. Often, multiple abnormal phenotypes are induced when a gene is inactivated. The International Mouse Phenotyping Consortium (IMPC) has generated thousands of mouse knockouts and catalogued their p
Externí odkaz:
https://doaj.org/article/82bd7caeac484fafbefa4cf0cc55a23b
Autor:
Keith Baar, Kyoungmi Kim, Jose Alberto Lopez-Dominguez, Bryan S. Roberts, Megan R. Showalter, Megan N. Roberts, Mittal Jasoliya, Gino A Cortopassi, Jennifer M. Rutkowsky, Jon J. Ramsey, Kevork Hagopian, Zeyu Zhou, José A. González-Reyes
Publikováno v:
Aging, vol 13, iss 6
Aging (Albany NY)
Aging (Albany NY)
Declines in mitochondrial mass are thought to be a hallmark of mammalian aging, and a ketogenic diet (KD) may prevent the age-related decreases in mitochondrial content. The objective of this study was to investigate the impact of a KD on markers of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e516f20d617b70fbda5546e42517cc
https://doi.org/10.18632/aging.202834
https://doi.org/10.18632/aging.202834
Autor:
Kelli Goodman, Megan R. Showalter, Anne M. Evans, Matthew W. Mitchell, Rangaprasad Sarangarajan
Publikováno v:
Cancer Research. 83:6607-6607
The COVID19 pandemic accelerated opportunities for innovation within the decentralization process of clinical trials with opportunities for implementation of patient-centric workflows for efficiency and cost-reduction. Decentralized sample collection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be9be8ef3012a8bf7f2f3365d877de2b
https://doi.org/10.1158/1538-7445.am2023-6607
https://doi.org/10.1158/1538-7445.am2023-6607
Autor:
Anastasia L. Berg, Megan R. Showalter, Nont Kosaisawe, Michelle Hu, Nathanial C. Stephens, Michael Sa, Hailey Heil, Noemi Castro, Jenny J. Chen, Kacey VanderVorst, Madelyn R. Wheeler, Zachary Rabow, Tomas Cajka, John Albeck, Oliver Fiehn, Kermit L. Carraway
Publikováno v:
Cancer Letters. 557:216090
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4731ce25d98ac95d366596c0766e4c
https://doi.org/10.1016/j.canlet.2023.216090
https://doi.org/10.1016/j.canlet.2023.216090