Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Megan R. Chastney"'
Autor:
Johanna Lilja, Jasmin Kaivola, James R. W. Conway, Joni Vuorio, Hanna Parkkola, Pekka Roivas, Michal Dibus, Megan R. Chastney, Taru Varila, Guillaume Jacquemet, Emilia Peuhu, Emily Wang, Ulla Pentikäinen, Itziar Martinez D. Posada, Hellyeh Hamidi, Arafath K. Najumudeen, Owen J. Sansom, Igor L. Barsukov, Daniel Abankwa, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the development of KRAS inhibitors difficult. Here we identify the s
Externí odkaz:
https://doaj.org/article/aab4a06c715b4e4481e20d3e6037ab7e
Autor:
Jonathan D. Humphries, Junzhe Zha, Jessica Burns, Janet A. Askari, Christopher R. Below, Megan R. Chastney, Matthew C. Jones, Aleksandr Mironov, David Knight, Derek A. O'Reilly, Mark J. Dunne, David R. Garrod, Claus Jorgensen, Martin J. Humphries
Publikováno v:
Matrix Biology. 110:16-39
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to its aggressive progression, late detection and lack of druggable driver mutations, which often combine to result in unsuitability for surgical intervention. Together with activatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfee4f927422bbf2cde97522e154f49
https://doi.org/10.1016/j.matbio.2022.03.010
https://doi.org/10.1016/j.matbio.2022.03.010
Autor:
Jonathan D. Humphries, Martin J. Humphries, Matthew Jones, Junzhe Zha, Christopher R. Below, Alexander A. Mironov, David R. Garrod, David Knight, Derek A. O'Reilly, Claus Jørgensen, Megan R. Chastney, Janet A. Askari, Mark Dunne, Jessica Burns
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to its aggressive progression, late detection and lack of druggable driver mutations, which often combine to result in unsuitability for surgical intervention. Together with activatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f1158a21445e7b82aebc4d121a8cd53
https://doi.org/10.1101/2021.08.19.456969
https://doi.org/10.1101/2021.08.19.456969
Publikováno v:
Current biology : CB. 31(10)
Tissue architecture and function are orchestrated by an intricate repertoire of cellular adhesion and signalling receptors, and by the surrounding extracellular matrix (ECM). The essential role of cell-tissue interactions in guiding organogenesis was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ece9ad31047a4a3fa296a0ad50971fd
https://pubmed.ncbi.nlm.nih.gov/34033786
https://pubmed.ncbi.nlm.nih.gov/34033786
Publikováno v:
Chastney, M, Lawless, C & Humphries, M J 2020, ' Multiplexed proximity biotinylation coupled to mass spectrometry for defining integrin adhesion complexes ', Current Protocols in Cell Biology . https://doi.org/10.1002/cpcb.113
BioID, a proximity biotinylation technique, offers a valuable approach to examine the interactions occurring within protein complexes that complements traditional protein biochemical methods. BioID has various advantages that are beneficial to the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f114a43dd78a77325fb71892a3de5b01
https://pubmed.ncbi.nlm.nih.gov/32833344
https://pubmed.ncbi.nlm.nih.gov/32833344
Autor:
Matthew Jones, Martin J. Humphries, Stacey Warwood, Claus Jørgensen, Craig Lawless, Megan R. Chastney, David Knight, Jonathan D. Humphries
Publikováno v:
Chastney, M, Lawless, C, Humphries, J, Warwood, S, Jones, M, Knight, D, Jorgensen, C & Humphries, M J 2020, ' Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation ', Journal of Cell Biology, vol. 219, no. 8 . https://doi.org/10.1083/jcb.202003038
Journal of Cell Biology
The Journal of Cell Biology
Journal of Cell Biology
The Journal of Cell Biology
Chastney et al. use multiplexed proximity-dependent labeling to define the topology of integrin adhesion complexes. The data support current models of adhesome architecture and provide a resource to examine proximal relationships within the adhesome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1026f502efa46e2adffa27764c88b33c
https://pure.manchester.ac.uk/ws/files/172983913/jcb_202003038.pdf
https://pure.manchester.ac.uk/ws/files/172983913/jcb_202003038.pdf
Autor:
Claus Jørgensen, Matthew Jones, David Knight, Megan R. Chastney, Stacey Warwood, Martin J. Humphries, Craig Lawless, Jonathan D. Humphries
Integrin adhesion complexes (IACs) bridge the extracellular matrix to the actin cytoskeleton and transduce signals in response to both chemical and mechanical cues. The composition, interactions, stoichiometry and topological organisation of proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3186cdfbe0793aa9656d7923d152e7e8
https://doi.org/10.1101/2020.01.24.918458
https://doi.org/10.1101/2020.01.24.918458
Publikováno v:
Humphries, J, Chastney, M, Askari, J & Humphries, M J 2019, ' Signal transduction via integrin adhesion complexes ', Current opinion in cell biology, vol. 56, pp. 14-21 . https://doi.org/10.1016/j.ceb.2018.08.004
Integrin adhesion complexes (IACs) have evolved over millions of years to integrate metazoan cells physically with their microenvironment. It is presumed that the simultaneous interaction of thousands of integrin receptors to binding sites in anisotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f00310d9c02b760467156cba76e2ff
https://www.research.manchester.ac.uk/portal/en/publications/signal-transduction-via-integrin-adhesion-complexes(a93bff19-ddef-43d4-8e60-b2f62477170a).html
https://www.research.manchester.ac.uk/portal/en/publications/signal-transduction-via-integrin-adhesion-complexes(a93bff19-ddef-43d4-8e60-b2f62477170a).html