Zobrazeno 1 - 10 of 168 pro vyhledávání: '"Megan R Lerner"'
1
G-CSF Is a Novel Mediator of T-Cell Suppression and an Immunotherapeutic Target for Women with Colon Cancer
Autor: Anita L. Ray, Apryl S. Saunders, Robert A. Nofchissey, Megan A. Reidy, Maria Kamal, Megan R. Lerner, Kar-Ming Fung, Mark L. Lang, Joshua A. Hanson, Shaoxuan Guo, Maria G. Urdaneta-Perez, Samara E. Lewis, Michael Cloyde, Katherine T. Morris
Publikováno v: Clinical Cancer Research. 29:2158-2169
Purpose: G-CSF enhances colon cancer development. This study defines the prevalence and effects of increased G-CSF signaling in human colon cancers and investigates G-CSF inhibition as an immunotherapeutic strategy against metastatic colon cancer. Ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa31e59a5008c428f418ecf192c92970
https://doi.org/10.1158/1078-0432.ccr-22-3918
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2
Akademický článek
Dried plum polyphenolic extract combined with vitamin K and potassium restores trabecular and cortical bone in osteopenic model of postmenopausal bone loss
Autor: Jennifer L. Graef, Ping Ouyang, Yan Wang, Elizabeth Rendina-Ruedy, Megan R. Lerner, Denver Marlow, Edralin A. Lucas, Brenda J. Smith
Publikováno v: Journal of Functional Foods, Vol 42, Iss , Pp 262-270 (2018)
Dried plum has unique anabolic effects on bone, but the responsible bioactive components have remained unclear. This study investigated components of dried plum with potential osteoprotective activity utilizing aged, osteopenic Sprague Dawley rats fe
Externí odkaz: https://doaj.org/article/96ab7cfac85d4534a8797deae30523da
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3
Akademický článek
Distinguishing and phenotype monitoring of traumatic brain injury and post-concussion syndrome including chronic migraine in serum of Iraq and Afghanistan war veterans.
Autor: Jay S Hanas, James R S Hocker, Megan R Lerner, James R Couch
Publikováno v: PLoS ONE, Vol 14, Iss 4, p e0215762 (2019)
Traumatic Brain Injury (TBI) and persistent post-concussion syndrome (PCS) including chronic migraine (CM) are major health issues for civilians and the military. It is important to understand underlying biochemical mechanisms of these conditions, an
Externí odkaz: https://doaj.org/article/2059a63ddcd8467f858078664c4b2b01
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7
Akademický článek
Distinguishing Alzheimer’s Disease Patients and Biochemical Phenotype Analysis Using a Novel Serum Profiling Platform: Potential Involvement of the VWF/ADAMTS13 Axis
Autor: Jay S. Hanas, James R. S. Hocker, Christian A. Vannarath, Megan R. Lerner, Scott G. Blair, Stan A. Lightfoot, Rushie J. Hanas, James R. Couch, Linda A. Hershey
Publikováno v: Brain Sciences, Vol 11, Iss 5, p 583 (2021)
It is important to develop minimally invasive biomarker platforms to help in the identification and monitoring of patients with Alzheimer’s disease (AD). Assisting in the understanding of biochemical mechanisms as well as identifying potential nove
Externí odkaz: https://doaj.org/article/cf15017443b5450a9d5cfb7b2f70ca97
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8
Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model
Autor: Arlan Richardson, Megan R. Lerner, Rheal A. Towner, Debra Saunders, Rafal Gulej, Michelle Zalles, Nataliya Smith, Kathryn A. Morton
Publikováno v: GeroScience
Rapamycin (RAPA) is found to have neuro-protective properties in various neuroinflammatory pathologies, including brain aging. With magnetic resonance imaging (MRI) techniques, we investigated the effect of RAPA in a lipopolysaccharide (LPS)-induced
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2b5cf5ab1c5459908e90e0e79d0ef0
https://doi.org/10.1007/s11357-021-00363-9
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9
The role of sex in the innate and adaptive immune environment of metastatic colorectal cancer
Autor: Nathaniel Weygant, Sarah Adams, Robert A. Nofchissey, Michael B. Stout, Shaoxuan Guo, Megan A Reidy, Megan R. Lerner, Spencer L Hill, William L. Berry, Xiangyan Wu, Anita L. Ray, Eliseo F. Castillo, Maaz A Khan, Katherine T. Morris
Publikováno v: British Journal of Cancer
Background Women with colorectal cancer (CRC) have a significant survival advantage over men. Sex influences on the tumour microenvironment (TME) are not well characterised, despite the importance of immune response in CRC. We hypothesised that sex-d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac91461427a2c4ec1a1191deaf4b10e
https://doi.org/10.1038/s41416-020-0913-8
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10
Optimized monoclonal antibody treatment against ELTD1 for GBM in a G55 xenograft mouse model
Autor: Chase A. Brown, Kar Ming Fung, Nataliya Smith, Shannon Remerowski, Debra Saunders, Junyeong Jin, Michelle Zalles, Rheal A. Towner, Graham B. Wiley, Nadya Mamedova, Rafal Gulej, Kyusang Hwang, James Battiste, Megan R. Lerner, Junho Chung, Jadith Ziegler, Lincy Thomas, Jonathan D. Wren
Publikováno v: Journal of Cellular and Molecular Medicine
Glioblastoma is an aggressive brain tumour found in adults, and the therapeutic approaches available have not significantly increased patient survival. Recently, we discovered that ELTD1, an angiogenic biomarker, is highly expressed in human gliomas.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72924fee4dde080262b1a1759a2d65f7
https://doi.org/10.1111/jcmm.14867
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