Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Megan Podowski"'
Autor:
Carla Calvi, Megan Podowski, Armando Lopez-Mercado, Shana Metzger, Kaori Misono, Alla Malinina, Dustin Dikeman, Hataya Poonyagariyon, Leslie Ynalvez, Roshanak Derakhshandeh, Anne Le, Mark Merchant, Ralph Schwall, Enid R Neptune
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003228 (2013)
The alveolar compartment, the fundamental gas exchange unit in the lung, is critical for tissue oxygenation and viability. We explored hepatocyte growth factor (HGF), a pleiotrophic cytokine that promotes epithelial proliferation, morphogenesis, migr
Externí odkaz:
https://doaj.org/article/33127e411ddc49149e0d29cc7cb3106b
Autor:
Carla L Calvi, Megan Podowski, Franco R D'Alessio, Shana L Metzger, Kaori Misono, Hataya Poonyagariyagorn, Armando Lopez-Mercado, Therese Ku, Thomas Lauer, Christopher Cheadle, C Conover Talbot, Chunfa Jie, Sharon McGrath-Morrow, Landon S King, Jeremy Walston, Enid R Neptune
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20712 (2011)
Respiratory dysfunction is a major contributor to morbidity and mortality in aged populations. The susceptibility to pulmonary insults is attributed to "low pulmonary reserve", ostensibly reflecting a combination of age-related musculoskeletal, immun
Externí odkaz:
https://doaj.org/article/1095d237ce484a7f82988ad0bb385320
Autor:
Enid Neptune, Kaori Misono, Christopher Cheadle, Hataya Poonyagariyagorn, Armando Lopez-Mercado, Megan Podowski, Alan E. Berger, Therese Ku, Wayne Mitzner, Rubin M. Tuder, Sharon A. McGrath-Morrow, Thomas Lauer, Robert A. Wise, Harry C. Dietz, Shana Metzger, Carla L. Calvi
Publikováno v:
Journal of Clinical Investigation. 122:229-240
Chronic obstructive pulmonary disease (COPD) is a prevalent smoking-related disease for which no disease-altering therapies currently exist. As dysregulated TGF-β signaling associates with lung pathology in patients with COPD and in animal models of
Autor:
Marc K. Halushka, Tammy M. Holm, Francesco Ramirez, Daniel B. Rifkin, Kathleen L. Gabrielson, Ronald D. Cohn, Megan Podowski, Bart Loeys, Djahida Bedja, G. Liu, Jennifer P Habashi, Loretha Myers, David L. Huso, Daniel P. Judge, Enid Neptune, Erin C Klein, Harry C. Dietz, Timothy K. Cooper, Luca Carta, Carla L. Calvi
Publikováno v:
Journal of the American Society of Nephrology. 17:1759-1764
Marfan syndrome is a disease resulting from a mutation of the gene coding for fibrillin-1 ([1][1]), a protein that forms fibrils in the extracellular matrix, thus depleting elastic tissue of a key building block. As a result, the ascending aorta of t
Autor:
Harry C. Dietz, Megan Podowski, Marc K. Halushka, Kathleen L. Gabrielson, Tammy M. Holm, Erin C Klein, Djahida Bedja, David L. Huso, Loretha Myers, Timothy K. Cooper, Luca Carta, Francesco Ramirez, Carla L. Calvi, Ronald D. Cohn, Bart Loeys, Daniel B. Rifkin, Enid Neptune, Daniel P. Judge, Jennifer P Habashi, Guosheng Liu
Publikováno v:
Science. 312:117-121
Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected manifestations of MFS reflect excessive signaling by the transforming growth factor–β (TGF-β
Autor:
Shana Metzger, Hataya Poonyagariyon, Ralph H. Schwall, Kaori Misono, Mark Merchant, Enid Neptune, Anne Le, Dustin Dikeman, Megan Podowski, Roshanak Derakhshandeh, Alla Malinina, Leslie Ynalvez, Armando Lopez-Mercado, Carla L. Calvi
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003228 (2013)
PLoS Genetics
PLoS Genetics
The alveolar compartment, the fundamental gas exchange unit in the lung, is critical for tissue oxygenation and viability. We explored hepatocyte growth factor (HGF), a pleiotrophic cytokine that promotes epithelial proliferation, morphogenesis, migr
Autor:
Christopher Cheadle, Megan Podowski, Rubin M. Tuder, Carla L. Calvi, Shyam Biswals, Enid Neptune
Publikováno v:
The American journal of pathology. 175(1)
Alveolar enlargement, which is characteristic of bronchopulmonary dysplasia, congenital matrix disorders, and cigarette smoke-induced emphysema, is thought to result from enhanced inflammation and ensuing excessive matrix proteolysis. Although there
Autor:
Enid Neptune, Megan Podowski, Thomas Lauer, Michael A. O'Reilly, Sharon A. McGrath-Morrow, Min Yee, Rajesh K. Thimmulappa, Shyam Biswal
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 296(4)
Increased oxidative stress is associated with perinatal asphyxia and respiratory distress in the newborn period. Induction of nuclear factor erythroid 2 p45-related factor (Nrf2) has been shown to decrease oxidative stress through the regulation of s
Autor:
R. Ilona Linnoila, Enid Neptune, Megan Podowski, Ming-Jer Tsai, Carla L. Calvi, Harry C. Dietz, Jang Hyeon Cho, Joe G.N. Garcia, Rubin M. Tuder
Publikováno v:
The Journal of Biological Chemistry
Despite the importance of airspace integrity in vertebrate gas exchange, the molecular pathways that instruct distal lung formation are poorly understood. Recently, we found that fibrillin-1 deficiency in mice impairs alveolar formation and recapitul
Autor:
Alison Murphy, Hunter C. Champion, Linda S. Higgins, Enid Neptune, Megan Podowski, Lijie Zhen, Sarvajit Chakravarty, Kimberley Gordy, Larissa A. Shimoda, Satya Medicherla, Pravin B. Sehgal, Ari L. Zaiman, Rubin M. Tuder, Fang Xu, Andrew A. Protter
Publikováno v:
American journal of respiratory and critical care medicine. 177(8)
Pulmonary arterial hypertension is a progressive disease characterized by an elevation in the mean pulmonary artery pressure leading to right heart failure and a significant risk of death. Alterations in two transforming growth factor (TGF) signaling