Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Megan Noel"'
Autor:
Christopher Pignanelli, Dennis Ma, Megan Noel, Jesse Ropat, Fadi Mansour, Colin Curran, Simon Pupulin, Kristen Larocque, Jianzhang Wu, Guang Liang, Yi Wang, Siyaram Pandey
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-25 (2017)
Abstract Recently, research has focused on targeting the oxidative and metabolic vulnerabilities in cancer cells. Natural compounds like curcumin that target such susceptibilities have failed further clinical advancements due to the poor stability an
Externí odkaz:
https://doaj.org/article/541280dca3a14ddc9144ea845137126b
Autor:
Alexis Heaton, Amanda Ombeva, Deogratias Leopold, Golbert Kazoza, Patrick Nganji, Cathy Mugeni, Megan Noel, Yasmin Chandani
Publikováno v:
Journal of Pharmaceutical Policy and Practice, Vol 7, Iss sup1 (2014)
Externí odkaz:
https://doaj.org/article/93485354db684a4d88a3493d61eeea79
Autor:
Yasmin Chandani, Sarah Andersson, Alexis Heaton, Megan Noel, Mildred Shieshia, Amanda Mwirotsi, Kirstin Krudwig, Humphreys Nsona, Barbara Felling
Publikováno v:
Journal of Global Health, Vol 4, Iss 2 (2014)
A UNICEF review of the challenges to scaling up integrated community case management (iCCM) found that drug shortages were a common bottleneck. In many settings, little thought has gone into the design of supply chains to the community level and l
Externí odkaz:
https://doaj.org/article/53f7ec8eae134b1a8e6c0bbd21333008
Autor:
Mildred Shieshia, Megan Noel, Sarah Andersson, Barbara Felling, Soumya Alva, Smisha Agarwal, Amnesty Lefevre, Amos Misomali, Boniface Chimphanga, Humphreys Nsona, Yasmin Chandani
Publikováno v:
Journal of Global Health, Vol 4, Iss 2 (2014)
, , In 2010, 7.6 million children under five died globally – largely due to preventable diseases. Majority of these deaths occurred in sub–Saharan Africa. As a strategy to reduce child mortality, the Government of Malawi, in 2008, initiated int
Externí odkaz:
https://doaj.org/article/cfae837954a044c991ba6f045036043f
Autor:
Ammar Saleem, Mark Rodrigues, Dennis Ma, Inderpal Singh, Fadi Mansour, Ivan Ruvinov, John T. Arnason, Jesse Ropat, Christopher Pignanelli, Siyaram Pandey, Megan Noel, Cory Philion
Publikováno v:
Oncotarget
Cancer cells are reported to have elevated levels of reactive oxygen species (ROS) and are highly dependent on cellular defense mechanisms against oxidative stress. Numerous nutraceuticals and natural polyphenolic compounds have a wide range of abili
Autor:
Daniel Tarade, Megan Noel, Dennis Ma, Tyler Gilbert, Manika Gupta, Christopher Pignanelli, Siyaram Pandey, Sabrina Ma, Sergey Vshyvenko, Colin Curran, Jesse Ropat, Tomas Hudlicky, Fadi Mansour
Publikováno v:
The FASEB Journal. 32:417-430
Harsh adverse effects as a result of nonspecific targeting of chemotherapeutics currently pose obstacles in cancer therapy; thus, it would be invaluable to devise novel approaches to specifically target cancer cells. The natural compound pancratistat
Autor:
Sergey Vshyvenko, Alexander Dowhayko, Tyler Gilbert, James McNulty, Daniel Tarade, Christopher Pignanelli, Siyaram Pandey, Dennis Ma, Megan Noel, Kyle Stokes, Fadi Mansour, Tomas Hudlicky, Jonathan Collins, Scott Adams
Publikováno v:
Scientific Reports. 8
Scientific Reports 7; Article number: 42957; published online: 21 February 2017; updated: 04 July 2018 Jonathan Collins was omitted from the author list in the original version of this Article. This has been corrected in the PDF and HTML versions of
Autor:
Jesse Ropat, Kristen Elizabeth Larocque, Simon Pupulin, Colin Curran, Dennis Ma, Christopher Pignanelli, Siyaram Pandey, Fadi Mansour, Yi Wang, Guang Liang, Megan Noel, Jianzhang Wu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-25 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-25 (2017)
Recently, research has focused on targeting the oxidative and metabolic vulnerabilities in cancer cells. Natural compounds like curcumin that target such susceptibilities have failed further clinical advancements due to the poor stability and bioavai
Autor:
Dennis Ma, Christopher Pignanelli, Daniel Tarade, Tyler Gilbert, Megan Noel, Fadi Mansour, Scott Adams, Alexander Dowhayko, Kyle Stokes, Sergey Vshyvenko, Jonathan Collins, Tomas Hudlicky, James McNulty, Siyaram Pandey
Publikováno v:
Scientific Reports
Enhanced mitochondrial stability and decreased dependence on oxidative phosphorylation confer an acquired resistance to apoptosis in cancer cells, but may present opportunities for therapeutic intervention. The compound pancratistatin (PST) has been