Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Megan N. Michalski"'
Autor:
Megan N. Michalski, Bart O. Williams
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1311 (2023)
The ability to create genetically engineered mouse models (GEMMs) has exponentially increased our understanding of many areas of biology. Musculoskeletal biology is no exception. In this review, we will first discuss the historical development of GEM
Externí odkaz:
https://doaj.org/article/da31df96274545a49476f72a98dbd92b
Publikováno v:
Osteoporosis International. 33:2423-2433
Hypophosphatasia, the rare heritable disorder caused by TNAP enzyme mutations, presents wide-ranging severity of bone hypomineralization and skeletal abnormalities. Intermittent PTH (1-34) increased long bone volume in AlplHypophosphatasia is the rar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1751ddf6dc19da2f2fad12ffdc0029
https://doi.org/10.1007/s00198-022-06496-7
https://doi.org/10.1007/s00198-022-06496-7
Autor:
Ryan P. Liegel, Megan N. Michalski, Sanika Vaidya, Elizabeth Bittermann, Erin Finnerty, Chelsea A. Menke, Cassandra R. Diegel, Zhendong A. Zhong, Bart O. Williams, Rolf W. Stottmann
Publikováno v:
Development. 150
Frizzled 2 (FZD2) is a transmembrane Wnt receptor. We previously identified a pathogenic human FZD2 variant in individuals with FZD2-associated autosomal dominant Robinow syndrome. The variant encoded a protein with a premature stop and loss of 17 am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb5829693dce3be1fc341982265aa23
https://doi.org/10.1242/dev.201038
https://doi.org/10.1242/dev.201038
Publikováno v:
Current Topics in Developmental Biology ISBN: 9780128201671
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38d60506946b05a5f90c40434f4f4758
https://doi.org/10.1016/bs.ctdb.2023.01.004
https://doi.org/10.1016/bs.ctdb.2023.01.004
Autor:
Ryan P. Liegel, Megan N. Michalski, Sanika Vaidya, Elizabeth Bittermann, Erin Finnerty, Chelsea A. Menke, Cassandra R. Diegel, Zhendong A. Zhong, Bart O. Williams, Rolf W. Stottmann
FRIZZLED-2 (FZD2) is a transmembrane Wnt ligand receptor. We previously identified a pathogenic human FZD2 variant, encoding for a protein with a premature stop and loss of 17 amino acids. This includes a portion of the consensus DISHEVELLED binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c9ffcef1c3de2d362c3b915bd6ccdce
https://doi.org/10.1101/2022.06.02.494481
https://doi.org/10.1101/2022.06.02.494481
Autor:
Ryan C. Riddle, Bart O. Williams, Gabrielle E. Foxa, Megan N. Michalski, Priyanka Kushwaha, Ryan E. Tomlinson, Soohyun P. Kim
Publikováno v:
J Cell Physiol
The activation of the Wnt/β-catenin signaling pathway is critical for skeletal development but surprisingly little is known about the requirements for the specific frizzled (Fzd) receptors that recognize Wnt ligands. To define the contributions of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e436b392eff158667cac3ef93112e4
https://doi.org/10.1002/jcp.29563
https://doi.org/10.1002/jcp.29563
Autor:
Benjamin P. Sinder, Junro Yamashita, Megan N. Michalski, Laurie K. McCauley, Hernan Roca, Laura E. Zweifler, Amy J. Koh
Publikováno v:
Journal of Dental Research. 98:459-467
Ineffective oral wound healing is detrimental to patients’ oral health–related quality of life. Delineating the cellular mechanisms involved in optimal healing will elicit better approaches to treating patients with compromised healing. Osteal ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9aa524c8ee4960d13775a8f5fb358a9
https://doi.org/10.1177/0022034518821685
https://doi.org/10.1177/0022034518821685
Autor:
Jarrett Adams, Zhendong A. Zhong, Bart O. Williams, Megan N. Michalski, Transgenics Core, Stephane Angers, Karsten Melcher, Sachdev S. Sidhu, Cassandra R. Diegel, Ian Beddows, Kelly Suino-Powell, Levi L. Blazer, Vai Vivarium
It is currently accepted that Wnt receptors, Frizzleds (Fzd), have high functional redundancy, making individual receptors challenging to target therapeutically. Specifically, Fzd2 is believed to be functionally redundant with Fzd1 and Fzd7, findings
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::710d8e0978a7d2525d13c90622fd0a19
https://doi.org/10.1101/2021.01.27.428341
https://doi.org/10.1101/2021.01.27.428341
Autor:
J. Ignacio Aguirre, Laura E. Zweifler, Kamran Atabai, Erica M. Siismets, Benjamin P. Sinder, Anna L. Seydel, Amy J. Koh, Hernan Roca, Megan N. Michalski, Laurie K. McCauley
Publikováno v:
The FASEB Journal. 32:3730-3741
A prolonged increase in proinflammatory cytokines is associated with osteoporotic and autoimmune bone loss and, conversely, anti-inflammatory pathways are associated with protection against bone loss. Milk fat globule-epidermal growth factor (MFG-E)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d06306e8eb1e0bf2c5e55c7b8e77d04
https://doi.org/10.1096/fj.201701238r
https://doi.org/10.1096/fj.201701238r
Autor:
Flavia Q Pirih, Megan N Michalski, Sun W Cho, Amy J Koh, Janice E Berry, Eduardo Ghaname, Pachiyappan Kamarajan, Edith Bonnelye, Charles W Ross, Yvonne L Kapila, Pierre Jurdic, Laurie K McCauley
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13657 (2010)
Parathyroid hormone (PTH) stimulates hematopoietic cells through mechanisms of action that remain elusive. Interleukin-6 (IL-6) is upregulated by PTH and stimulates hematopoiesis. The purpose of this investigation was to identify actions of PTH and I
Externí odkaz:
https://doaj.org/article/1b8aaf0b755d4c758a95432cf71d4ee2