Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Megan N. Kelchen"'
Autor:
James Fisher, Karunya K. Kandimalla, Srinivasan Rajagopal, Anna M. Wokovich, Caroline Strasinger, Megan N. Kelchen, Nicole K. Brogden, Jamie Carr, Kenichi Ueda, Wei Ye, Priyanka Ghosh, Suresh Kumar Swaminathan
Publikováno v:
AAPS PharmSciTech. 21
To estimate strength of a scopolamine transdermal delivery system (TDS) in vivo, using residual drug vs. pharmacokinetic analyses with the goal of scientifically supporting a single and robust method for use across the dosage form and ultimately faci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1159b8de1c036af65bbe1aeee9a29ae
https://doi.org/10.1208/s12249-020-01658-4
https://doi.org/10.1208/s12249-020-01658-4
Autor:
Megan N. Kelchen, Nicole K. Brogden
Publikováno v:
Biomedical Microdevices. 20
Topical beta-blocker formulations are commonly used to treat infantile hemangiomas (IHs); however, the skin concentrations and drug permeation through the skin have not been quantified. Microneedles (MNs) may increase local skin concentrations, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d80b99ce1c50a385cd04e803b070778
https://doi.org/10.1007/s10544-018-0348-7
https://doi.org/10.1007/s10544-018-0348-7
Autor:
Megan N. Kelchen, Grant O. Holdren, Kyle Siefers, Matthew J. Farley, Courtney C. Converse, Nicole K. Brogden
Publikováno v:
Journal of Controlled Release. 225:294-300
Transdermal delivery is an advantageous method of drug administration, particularly for an elderly population. Microneedles (MNs) allow transdermal delivery of otherwise skin-impermeable drugs by creating transient micropores that bypass the barrier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9109a7bd1324aa3e4d84a1f963560ab6
https://doi.org/10.1016/j.jconrel.2016.01.051
https://doi.org/10.1016/j.jconrel.2016.01.051
Autor:
Megan N. Kelchen, Nicole K. Brogden
Publikováno v:
Pharmaceutical Research. 35
PURPOSE: Topical beta-blockers are efficacious for treating infantile hemangiomas, but no formulations have been specifically optimized for skin delivery. Our objective was to quantify skin concentrations and drug permeation of propranolol (a nonsele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db55d32ea390c0304d8e20b7dcbd4e8
https://doi.org/10.1007/s11095-018-2495-1
https://doi.org/10.1007/s11095-018-2495-1
Publikováno v:
Skin pharmacology and physiology. 31(5)
Application of exogenous products, such as creams, to the skin can result in subclinical changes in selected epidermal functions such as transepidermal water loss (TEWL), hydration, redness, and pH; these changes may lead to or contribute to irritati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75618aae06fcf9777632a4a7aca861f
https://pubmed.ncbi.nlm.nih.gov/30110695
https://pubmed.ncbi.nlm.nih.gov/30110695
Autor:
M. Bridget Zimmerman, Matthew J. Farley, Grant O. Holdren, Nicole K. Brogden, Megan N. Kelchen, Janet A. Fairley
Publikováno v:
Pharmaceutical Research. 31:3478-3486
The objective of this study was to optimize a reproducible impedance spectroscopy method in elderly subjects as a means to evaluate the effects of microneedles on aging skin.Human volunteers were treated with microneedles at six sites on the upper ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399e485edc54bd02152b43e75b7893b1
https://doi.org/10.1007/s11095-014-1435-y
https://doi.org/10.1007/s11095-014-1435-y