Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Megan Montoya"'
Publikováno v:
Cells, Vol 13, Iss 9, p 726 (2024)
Glioblastoma (GBM) is the most common primary malignant brain tumor, with a median overall survival of less than 2 years and a nearly 100% mortality rate under standard therapy that consists of surgery followed by combined radiochemotherapy. Therefor
Externí odkaz:
https://doaj.org/article/3dae77d1791d4782aad897b928c2884d
Autor:
Pavlina Chuntova, Kira Downey, Ryusuke Hatae, Tiffany A Chen, Abigail L Mende, Megan Montoya, Bjoern Schwer, Jayne Skinner, Hideho Okada, Gary Kohanbash, Takahide Nejo, Yitzhar E. Goretsky, Yafei Hou, Hong-Erh Liang, David Diebold, Akane Yamamichi, Ryosuke Naka
Publikováno v:
Neuro-oncology, vol 24, iss 2
Neuro Oncol
Neuro Oncol
Background Rigorous preclinical studies of chimeric antigen receptor (CAR) immunotherapy will require large quantities of consistent and high-quality CAR-transduced T (CART) cells that can be used in syngeneic mouse glioblastoma (GBM) models. To this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e413a9fb76c4ae0a30fdd3ad9738da0b
https://doi.org/10.1093/neuonc/noab182
https://doi.org/10.1093/neuonc/noab182
Autor:
Pavlina Chuntova, Akane Yamamichi, Tiffany Chen, Rohini Narayanaswamy, Sebastien Ronseaux, Christine Hudson, Adriana E Tron, Marc L Hyer, Megan Montoya, Abigail L Mende, Takahide Nejo, Kira M Downey, David Diebold, Min Lu, Brandon Nicolay, Hideho Okada
Publikováno v:
Journal for immunotherapy of cancer, vol 10, iss 5
BackgroundLong-term prognosis of WHO grade II, isocitrate dehydrogenase (IDH)-mutated low-grade glioma (LGG) is poor due to high risks of recurrence and malignant transformation into high-grade glioma. Immunotherapy strategies are attractive given th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5327e3311d9f2d9383543f4b19111e8
https://escholarship.org/uc/item/37d5t20s
https://escholarship.org/uc/item/37d5t20s
Publikováno v:
Neurooncol Pract
Neuro-oncology practice, vol 7, iss 5
Neuro-oncology practice, vol 7, iss 5
Malignant gliomas, including glioblastoma (GBM) as the most aggressive type of adult CNS tumors, are notoriously resistant to current standard of care treatments, including surgery, systemic chemotherapy, and radiation therapy (RT). This lack of effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a861deeae146fa68402db7ad1ea1cfaa
https://doi.org/10.1093/nop/npaa007
https://doi.org/10.1093/nop/npaa007
Autor:
Blake L. Scott, Megan Montoya, Ahlam Farzan, Melanie Cruz, Mitchell Jaskela, Beatrice Smith, Madeleine LaGoy, Jennifer Marshall
Publikováno v:
Maternal and child health journal. 26(3)
In recent years, catastrophic hurricanes have devastated numerous areas, prompting a need to build resilience particularly in at-risk populations that rely on health care and social services. The Maternal and Child Health (MCH) workforce covers a wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c44b94f0ae78ced8404b4b279e36c3
https://pubmed.ncbi.nlm.nih.gov/35039975
https://pubmed.ncbi.nlm.nih.gov/35039975
Autor:
Tiffany A Chen, David Diebold, Yitzhar E. Goretsky, Hideho Okada, Bjoern Schwer, Yafei Hou, Jayne Skinner, Hong-Erh Liang, Abigail L Mende, Ryosuke Naka, Pavlina Chuntova, Kira Downey, Megan Montoya, Gary Kohanbash, Takahide Nejo, Akane Yamamichi
BackgroundRigorous preclinical studies of chimeric antigen receptor (CAR) immunotherapy will require large quantities of consistent and high-quality CAR-transduced T (CART)-cells that can be used in syngeneic mouse glioblastoma (GBM) models. To this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b86bcff4afeb945f4ecee99fa7142dc
https://doi.org/10.1101/2021.01.31.429020
https://doi.org/10.1101/2021.01.31.429020
Autor:
Pavlina Chuntova, Megan Montoya, Noriyuki Kasahara, Nikhil V. Mummaneni, Manish K. Aghi, Matheus P. Pereira, Jacob S. Young, Sara Collins, Alexander F Haddad, Sabraj Gill, Jordan Spatz
Publikováno v:
Neurosurgery. 67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6603700684e2064963cf2e1936e6434f
https://doi.org/10.1093/neuros/nyaa447_843
https://doi.org/10.1093/neuros/nyaa447_843
Autor:
Noriyuki Kasahara, Manish K. Aghi, Alexander F Haddad, Megan Montoya, Polly Chuntova, Sara Collins, Jordan Spatz, Jacob S. Young, Sabraj Gill, Elaina Wang
Publikováno v:
Neuro-Oncology. 23:vi166-vi166
Glioblastoma (GBM) leads to severe systemic and local immunosuppression, and immunotherapies have had limited clinical success. Here, we evaluated the treatment efficacy of RLI, a superagonist of T-cell activator IL-15, delivered to tumor cells using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0402e36e072ec22adb281f3ae83f800c
https://doi.org/10.1093/neuonc/noab196.652
https://doi.org/10.1093/neuonc/noab196.652
Autor:
Sara Collins, Alicia Freedman, Akihito Inagaki, Alexander F Haddad, Noriyuki Kasahara, Megan Montoya, Maria Barcova
Publikováno v:
Neuro-Oncology. 23:vi170-vi170
Amphotropic retroviral replicating vector (RRV) Toca 511, expressing the yeast cytosine deaminase (CD) prodrug activator gene, showed promising evidence of therapeutic benefit and increased survival in early-phase trials for recurrent high-grade glio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d1627d87ee93a4c7b416b9bd3b23242
https://doi.org/10.1093/neuonc/noab196.672
https://doi.org/10.1093/neuonc/noab196.672
Autor:
Sebastien Ronseaux, Kira Downey, Brandon Nicolay, Rohini Narayanaswamy, Megan Montoya, Christine Hudson, Hideho Okada, Polly Chuntova
Publikováno v:
Neuro Oncol
Recent studies have demonstrated the impacts of 2-HG on the anti-tumor immune response in isocitrate dehydrogenase (IDH)-mutant gliomas. Our laboratory has reported that mutant IDH1 (IDH1R132H) suppresses STAT1, the master regulator of IFN-responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610be558b0dcc30dae348599b00ac9ba
https://doi.org/10.1093/neuonc/noaa215.369
https://doi.org/10.1093/neuonc/noaa215.369