Výsledky vyhledávání - "Megan McKerlie"

Phosphorylated (pT371)TRF1 is recruited to sites of DNA damage to facilitate homologous recombination and checkpoint activation

Autor: Megan McKerlie, John R. Walker, Xu-Dong Zhu, Florence R. Wilson, Taylor R. H. Mitchell

Publikováno v: Nucleic Acids Research

TRF1, a duplex telomeric DNA-binding protein, plays an important role in telomere metabolism. We have previously reported that a fraction of endogenous TRF1 can stably exist free of telomere chromatin when it is phosphorylated at T371 by Cdk1; howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7672d8a062a53a80243a2877a25ce8c
https://doi.org/10.1093/nar/gkt775

Zobrazit plný text záznamu

Cyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of sister telomeres

Autor: Megan McKerlie, Xu-Dong Zhu

Publikováno v: Nature communications

Cyclin B-Cdk1 is a key mediator of mitotic entry; however, little is known about its role in the separation of sister chromatids. Here we report that upon mitotic entry, Cdk1 specifically phosphorylates threonine 371 of TRF1, a telomere binding prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ff42fadf71bd77f2de96184a265324
https://pubmed.ncbi.nlm.nih.gov/21712819

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání