Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV.

Autor: Christopher Chiu, Megan McCausland, John Sidney, Fuh-Mei Duh, Nadine Rouphael, Aneesh Mehta, Mark Mulligan, Mary Carrington, Andreas Wieland, Nicole L Sullivan, Adriana Weinberg, Myron J Levin, Bali Pulendran, Bjoern Peters, Alessandro Sette, Rafi Ahmed

Publikováno v: PLoS Pathogens, Vol 10, Iss 3, p e1004008 (2014)

Human herpesviruses are important causes of potentially severe chronic infections for which T cells are believed to be necessary for control. In order to examine the role of virus-specific CD8 T cells against Varicella Zoster Virus (VZV), we generate

Externí odkaz: https://doaj.org/article/af80c0ad3e1c4b5783089177fff3ccd3

2020 White Paper on Recent Issues in Bioanalysis: BAV Guidance, CLSI H62, Biotherapeutics Stability, Parallelism Testing, CyTOF and Regulatory Feedback (Part 2A – Recommendations on Biotherapeutics Stability, PK LBA Regulated Bioanalysis, Biomarkers Assays, Cytometry Validation & Innovation Part 2B – Regulatory Agencies’ Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine)

Autor: Andrew P Mayer, Jinhui Zhang, Sam Haidar, Sandra Nuti, Shyam Sarikonda, Therese Solstad, Megan McCausland, Fabian Junker, Elana Cherry, Susan M. Spitz, Tahseen Mirza, Anna Edmison, Patrick Faustino, Yan Zhang, Rafiq Islam, Steven Eck, Christèle Gonneau, Fabio Garofolo, Nilufer Tampal, Kevin Maher, Lisa Patti-Diaz, Kun Peng, Alberto Robert, Yow-Ming Wang, Rachel Palmer, Marcela Araya, Lakshmi Amaravadi, Alison Joyce, Daniela Verthelyi, Giane Sumner, Andrew Exley, Sally Fischer, Gustavo Mendes Lima Santos, Michael McGuinness, Yoshiro Saito, Alessandra Vitaliti, Naveen Dakappagari, Daniel Baltrukonis, Christina Satterwhite, Gregory Hopkins, Gregor Jordan, Akiko Ishii-Watabe, Arindam Dasgupta, David Lanham, Priscila Camillo Teixeira, Mitra Azadeh, Stephen Vinter, Sumit Kar, Lucia Zhang, Linda Terry, Michael Nathan Hedrick, João Pedras-Vasconcelos, Shabnam Tangri, Florian Neff, Natasha Savoie, Weili Yan, Matthew Andisik, Mohsen Rajabi Abhari, Richard Siggers, Lindsay King, Diaa Shakleya, Isabelle Cludts, Nisha Palackal, Meiyu Shen, Ulrike Sommer, Sylvie Bertholet, Susan Kirshner, Cherie Green, Christine Grimaldi, Susan Stojdl, Kristina McGuire, Vilma Decman, Jose Estevam, Suman Dandamudi, Seema Kumar, Richard Wnek, Catherine Soo, Haoheng Yan, Jan Welink, Rebecca Elliott, Abbas Bandukwala

Publikováno v: Bioanalysis. 13:295-361

The 14th edition of the Workshop on Recent Issues in Bioanalysis (14th WRIB) was held virtually on June 15-29, 2020 with an attendance of over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5706237408b458c58ed63921b541745
https://doi.org/10.4155/bio-2021-0005

With great power comes great responsibility: high-dimensional spectral flow cytometry to support clinical trials

Autor: Megan McCausland, Chris Groves, Vilma Decman, Yi-Dong Lin, Tania Nevers

Publikováno v: Bioanalysis. 13(21)

Flow cytometry is a powerful technology used in research, drug development and clinical sample analysis for cell identification and characterization, allowing for the simultaneous interrogation of multiple targets on various cell subsets from limited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b64f1bce0a35471982575c76de44b9
https://pubmed.ncbi.nlm.nih.gov/34708658

Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans

Autor: Nadine Rouphael, Megan McCausland, Chakravarthy Chennareddy, Mario Cortese, Carl W. Davis, Cathy Y. Chang, Ali H. Ellebedy, Rafi Ahmed, Mark J. Mulligan, Veronika Chromikova, Arvind Rajabhathor, Daniel Stadlbauer, Scott D. Boyd, Florian Krammer, Julianna Han, Cheyann Kazemian, Katherine J. L. Jackson, Daved H. Fremont, Ya Nan Dai, Raffael Nachbagauer, Aaron J. Schmitz, Veronika I. Zarnitsyna, Mary Bower, Wafaa B. Alsoussi, Andrew B. Ward, Bali Pulendran, Rustom Antia, Lilin Lai

Publikováno v: Proc Natl Acad Sci U S A

There is a need for improved influenza vaccines. In this study we compared the antibody responses in humans after vaccination with an AS03-adjuvanted versus nonadjuvanted H5N1 avian influenza virus inactivated vaccine. Healthy young adults received t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fe10373226b129cd9d237a2baaed9c
https://pubmed.ncbi.nlm.nih.gov/32661157

Novel multiplex assay platforms to detect influenza A hemagglutinin subtype‐specific antibody responses for high‐throughput and in‐field applications

Autor: Kimberly M. Weber, Katharine Sturm-Ramirez, Elizabeth LeMasters, Min Z. Levine, Angelo H. Gunasekera, Javan Esfandiari, Jacqueline M. Katz, James Stevens, Joseph D. Miller, Zhu-Nan Li, Vic Veguilla, Sharifa Nasreen, Jessica F. Trost, Sean Gregory, Megan McCausland, Jens Wrammert

Publikováno v: Influenza and Other Respiratory Viruses

Background Detections of influenza A subtype specific antibody responses are often complicated by the presence of cross-reactive antibodies. We developed two novel multiplex platforms for antibody detection. The multiplexed magnetic fluorescence micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a87a2532cbd2aefde6bbe72fd420a94
http://europepmc.org/articles/PMC5410722