Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Megan M. Wyatt"'
Autor:
Kelsey B. Bennion, Danya Liu, Abdelhameed S. Dawood, Megan M. Wyatt, Katie L. Alexander, Mohamed S. Abdel-Hakeem, Chrystal M. Paulos, Mandy L. Ford
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The regulatory circuits dictating CD8+ T cell responsiveness versus exhaustion during anti-tumor immunity are incompletely understood. Here we report that tumor-infiltrating antigen-specific PD-1+ TCF-1− CD8+ T cells express the immunosupp
Externí odkaz:
https://doaj.org/article/ac5c51a14c4148dcaf211da0aa6ca675
Autor:
Hannah M. Knochelmann, Joshua D. Horton, Sixue Liu, Kent Armeson, John M. Kaczmar, Megan M. Wyatt, Mary S. Richardson, Shirley H. Lomeli, Ying Xiong, Evan M. Graboyes, Eric J. Lentsch, Joshua D. Hornig, Judith Skoner, Seth Stalcup, Maria V. Spampinato, Elizabeth Garrett-Mayer, Elizabeth C. O’Quinn, Cynthia D. Timmers, Martin J. Romeo, John M. Wrangle, M. Rita I. Young, Mark P. Rubinstein, Terry A. Day, Roger S. Lo, Chrystal M. Paulos, David M. Neskey
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 10, Pp 100426- (2021)
Summary: Oral cavity squamous cell carcinoma (OCSCC) is a prevalent surgically treated subset of head and neck cancer with frequent recurrence and poor survival. Immunotherapy has demonstrated efficacy in recurrent/metastatic head and neck cancer. Ho
Externí odkaz:
https://doaj.org/article/106d0eef51b345229c78936aef78ee40
Autor:
Guillermo O. Rangel Rivera, Hannah M. Knochelmann, Connor J. Dwyer, Aubrey S. Smith, Megan M. Wyatt, Amalia M. Rivera-Reyes, Jessica E. Thaxton, Chrystal M. Paulos
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Emerging reports show that metabolic pathways can be targeted to enhance T cell-mediated immunity to tumors. Yet, tumors consume key metabolites in the host to survive, thus robbing T cells of these nutrients to function and thrive. T cells are often
Externí odkaz:
https://doaj.org/article/b97a96fc05df4b82bb16cd5baaca35a4
Autor:
Stefanie R. Bailey, Michelle H. Nelson, Kinga Majchrzak, Jacob S. Bowers, Megan M. Wyatt, Aubrey S. Smith, Lillian R. Neal, Keisuke Shirai, Carmine Carpenito, Carl H. June, Michael J. Zilliox, Chrystal M. Paulos
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The role of human CD4+ T cell subsets in cancer immunotherapy is still unclear. Here, the authors show that CD26 identifies three CD4+ T cell subsets with distinct immunological properties in both healthy individuals and cancer patients.
Externí odkaz:
https://doaj.org/article/63f1a5f94c67463f9202a2a71250b8b7
Autor:
Connor J. Dwyer, Hannah M. Knochelmann, Aubrey S. Smith, Megan M. Wyatt, Guillermo O. Rangel Rivera, Dimitrios C. Arhontoulis, Eric Bartee, Zihai Li, Mark P. Rubinstein, Chrystal M. Paulos
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Adoptive T cell transfer therapy (ACT) using tumor infiltrating lymphocytes or lymphocytes redirected with antigen receptors (CAR or TCR) has revolutionized the field of cancer immunotherapy. Although CAR T cell therapy mediates robust responses in p
Externí odkaz:
https://doaj.org/article/825995c99c0a4d7983aee31e01cf63b3
Autor:
Hannah M. Knochelmann, Aubrey S. Smith, Connor J. Dwyer, Megan M. Wyatt, Shikhar Mehrotra, Chrystal M. Paulos
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Genetic redirection of T lymphocytes with chimeric antigen receptors (CARs) has soared from treating cancers preclinically to FDA approval for hematologic malignancies and commercial-grade production scale in under 30 years. To date, solid tumors are
Externí odkaz:
https://doaj.org/article/229323c4814e4454ae5f589352312db2
Autor:
Jacob S. Bowers, Kinga Majchrzak, Michelle H. Nelson, Bulent Arman Aksoy, Megan M. Wyatt, Aubrey S. Smith, Stefanie R. Bailey, Lillian R. Neal, Jeffrey E. Hammerbacher, Chrystal M. Paulos
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibition by Idelalisib (CAL-101) in hematological malignancies directly induces apoptosis in cancer cells and disrupts immunological tolerance by depleting regulatory T cells. Yet, little is known about
Externí odkaz:
https://doaj.org/article/692b7233642b4e4695b1d1a1960096eb
Autor:
Gregory B Lesinski, Chrystal M Paulos, Hannah M Knochelmann, Megan M Wyatt, Guillermo O Rangel Rivera, Anna C Cole, Megen C Wittling
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 6 (2024)
Background How distinct methods of host preconditioning impact the efficacy of adoptively transferred antitumor T helper cells is unknown.Methods CD4+ T cells with a transgenic T-cell receptor that recognize tyrosinase-related peptide (TRP)-1 melanom
Externí odkaz:
https://doaj.org/article/fe2e22541bba40599235ed797c618c73
Autor:
Megan M. Wyatt, Logan W. Huff, Michelle H. Nelson, Lillian R. Neal, Andrew R. Medvec, Guillermo O. Rangel Rivera, Aubrey S. Smith, Amalia M. Rivera Reyes, Hannah M. Knochelmann, James L. Riley, Gregory B. Lesinski, Chrystal M. Paulos
Publikováno v:
Molecular Therapy.
Autor:
Chrystal M. Paulos, Laura L. Carter, Weiping Zou, Jacques Moisan, Chauncey J. Spooner, Megan M. Wyatt, Xikui Liu, Kinga Majchrzak, Xiao Hu
Adoptive T-cell transfer therapy is an FDA- approved treatment for leukemia that relies on the ex vivo expansion and reinfusion of a patient's immune cells, which can be engineered with a chimeric antigen receptor (CAR) for more efficient tumor recog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d038dd577344f768f7d9f83e5b76b18
https://doi.org/10.1158/0008-5472.c.6510324
https://doi.org/10.1158/0008-5472.c.6510324