Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Megan M. McNulty"'
1
Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels
Autor: Megan M. McNulty, Ravi D. Shah, Gabrielle B. Edgerton, Gregory M. Lipkind, Dorothy A. Hanck, Harry A. Fozzard
Publikováno v: The Journal of Physiology. 581:741-755
Our homology molecular model of the open/inactivated state of the Na+ channel pore predicts, based on extensive mutagenesis data, that the local anaesthetic lidocaine docks eccentrically below the selectivity filter, such that physical occlusion is i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5641a357f124c775b28d4b7309b62566
https://doi.org/10.1113/jphysiol.2007.130161
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2
State-Dependent Verapamil Block of the Cloned Human Cav3.1 T-Type Ca2+ Channel
Autor: Benjamin S. Freeze, Dorothy A. Hanck, Megan M. McNulty
Publikováno v: Molecular Pharmacology. 70:718-726
Verapamil is a potent phenylalkylamine antihypertensive believed to exert its therapeutic effect primarily by blocking high-voltage-activated L-type calcium channels. It was the first clinically used calcium channel blocker and remains in clinical us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85b3164cbe24f4776a125d8e3bb62b1
https://doi.org/10.1124/mol.106.023473
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3
State-Dependent Mibefradil Block of Na+ Channels
Autor: Megan M. McNulty, Dorothy A. Hanck
Publikováno v: Molecular Pharmacology. 66:1652-1661
Mibefradil is a T-type Ca2+ channel antagonist with reported cross-reactivity with other classes of ion channels, including K+, Cl-, and Na+ channels. Using whole-cell voltage clamp, we examined mibefradil block of four Na+ channel isoforms expressed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9258150647b6de6bdaafeeec262d8c32
https://doi.org/10.1124/mol.66.6.1652
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4
Using Lidocaine and Benzocaine to Link Sodium Channel Molecular Conformations to State-Dependent Antiarrhythmic Drug Affinity
Autor: Megan M. McNulty, Harry A. Fozzard, Elena Nikitina, Michael F. Sheets, Dorothy A. Hanck, Gregory M. Lipkind
Rationale : Lidocaine and other antiarrhythmic drugs bind in the inner pore of voltage-gated Na channels and affect gating use-dependently. A phenylalanine in domain IV, S6 (Phe1759 in Na V 1.5), modeled to face the inner pore just below the selectiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0406fadd7df4e84ce625cf74e094c016
https://europepmc.org/articles/PMC2735213/
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6
An inner pore residue (Asn406) in the Nav1.5 channel controls slow inactivation and enhances mibefradil block to T-type Ca2+ channel levels
Autor: Dorothy A. Hanck, Megan M. McNulty, John W. Kyle, Gregory M. Lipkind
Publikováno v: Molecular pharmacology. 70(5)
Mibefradil is a tetralol derivative once marketed to treat hyper-tension. Its primary target is the T-type Ca(2+) channel (IC(50), approximately 0.1-0.2 microM), but it also blocks Na(+),K(+),Cl(-), and other Ca(2+) channels at higher concentrations.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4bf673cf092d56681a647c34c307c87
https://pubmed.ncbi.nlm.nih.gov/16885209
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7
Profiling the array of Ca(v)3.1 variants from the human T-type calcium channel gene CACNA1G: alternative structures, developmental expression, and biophysical variations
Autor: Rebecca Stein, Mark C. Emerick, Robin Kunze, Dorothy A. Hanck, Melissa R. Regan, Megan M. McNulty, William S. Agnew
Publikováno v: Proteins. 64(2)
We describe the regulated transcriptome of CACNA1G, a human gene for T-type Ca v 3.1 calcium channels that is subject to extensive alternative RNA splicing. Fifteen sites of transcript variation include 2 alternative 5'-UTR promoter sites, 2 alternat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4215f50b014a01f219fd4b6940e3698
https://pubmed.ncbi.nlm.nih.gov/16671074
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8
Role of Domain IV/S4 outermost arginines in gating of T-type calcium channels
Autor: Maria Chikina, Megan M. McNulty, Ian W. Glaaser, Dorothy A. Hanck, Alice D. Lam
Publikováno v: Pflugers Archiv : European journal of physiology. 451(2)
The role of the outermost three charged residues of Domain IV/S4 in controlling gating of Ca(v)3.2 was investigated using single substitutions of each arginine with glutamine, cysteine, histidine, and lysine in a Flp-In-293 cell line, in which expres
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d317e593beb61e3b1a64a7a10149bf7
https://pubmed.ncbi.nlm.nih.gov/16133267
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9
Evidence that a copper-metallothionein complex is responsible for fluorescence in acid-secreting cells of the Drosophila stomach
Autor: Megan M. McNulty, Michael C. Puljung, Ronald R. Dubreuil, Greg Jefford
Publikováno v: Cell and tissue research. 304(3)
Copper cells were originally identified in Drosophila midgut epithelium by their striking orange fluorescence in copper-fed larvae. Here, we examined copper cell fluorescence in light of the previous observations that (1) a similar fluorescent signal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783a3884d703440f3425a660c84c42f7
https://pubmed.ncbi.nlm.nih.gov/11456415
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