Výsledky vyhledávání - "Megan M. Marlow"

Akademický článek

Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF

Publikováno v: Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)

Abstract Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs. Obj

Externí odkaz: https://doaj.org/article/f75a5266ef724db48db905d69406f78e

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Akademický článek

The Effects of the Combination of Mesenchymal Stromal Cells and Nanofiber-Hydrogel Composite on Repair of the Contused Spinal Cord

Autor: Agnes E. Haggerty, Ines Maldonado-Lasunción, Yohshiro Nitobe, Kentaro Yamane, Megan M. Marlow, Hua You, Chi Zhang, Brian Cho, Xiaowei Li, Sashank Reddy, Hai-Quan Mao, Martin Oudega

Publikováno v: Cells, Vol 11, Iss 7, p 1137 (2022)

A bone marrow-derived mesenchymal stromal cell (MSC) transplant and a bioengineered nanofiber-hydrogel composite (NHC) have been shown to stimulate nervous tissue repair in the contused spinal cord in rodent models. Here, these two modalities were co

Externí odkaz: https://doaj.org/article/aa22a86eeecd4ac7860a7b887676db52

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Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF

Publikováno v: Respiratory research, vol 22, iss 1
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)

Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs. Objectives W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8943da51a8a3553a1e3711bc9a9ed07
https://escholarship.org/uc/item/5q12m0vq

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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

Publikováno v: Sci Transl Med
Science translational medicine, vol 12, iss 557

Hepatic stellate cells (HSCs) drive hepatic fibrosis. Therapies that inactivate HSCs have clinical potential as antifibrotic agents. We previously identified acid ceramidase (aCDase) as an antifibrotic target. We showed that tricyclic antidepressants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a4b8c3ed8a9921917b7e90c8313188
https://europepmc.org/articles/PMC7976849/

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The effect of a nanofiber-hydrogel composite on neural tissue repair and regeneration in the contused spinal cord

Publikováno v: Biomaterials, 245. Elsevier B.V.
Biomaterials

An injury to the spinal cord causes long-lasting loss of nervous tissue because endogenous nervous tissue repair and regeneration at the site of injury is limited. We engineered an injectable nanofiber-hydrogel composite (NHC) with interfacial bondin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2dea0358d1cef1bf4ab2931097ce66
https://hdl.handle.net/20.500.11755/410169a6-e434-402b-ac6f-7d22ae7fae2f

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Targeting Glioblastoma Stem Cells with 2-Deoxy-D-Glucose (2-DG) Potentiates Radiation-Induced Unfolded Protein Response (UPR)

Autor: Winston M. Walters, Brian Marples, Alexis J. Musick, Gregor A. Rodriguez, Nicolas de Cordoba, Ricardo J. Komotar, Jeffrey S. Prince, Regina M. Graham, Steven Vanni, Eric Barbarite, Megan M. Marlow, Sumedh S. Shah

Publikováno v: Cancers
Volume 11
Issue 2
Cancers, Vol 11, Iss 2, p 159 (2019)

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, and despite optimized treatment options, median survival remains dismal. Contemporary evidence suggests disease recurrence results from expansion of a robustly radior

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ffa1028beb7d647762142688faf90d

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Transradial access: lessons learned from cardiology

Autor: Mauricio G. Cohen, Eric C. Peterson, Samir Sur, Brian Snelling, Megan M. Marlow, Sumedh S. Shah

Publikováno v: Journal of neurointerventional surgery. 10(5)

Innovations in interventional cardiology historically predate those in neuro-intervention. As such, studying trends in interventional cardiology can be useful in exploring avenues to optimise neuro-interventional techniques. One such cardiology innov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3c2db56d51843e3a907cac1df14c10
https://pubmed.ncbi.nlm.nih.gov/28963366

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Extracellular matrix components as therapeutics for spinal cord injury

Autor: Martin Oudega, Megan M. Marlow, Agnes E. Haggerty

Publikováno v: Neuroscience letters. 652

There is no treatment for people with spinal cord injury that leads to significant functional improvements. The extracellular matrix is an intricate, 3-dimensional, structural framework that defines the environment for cells in the central nervous sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7283f294ceb7d57b7a851b7f83674e5
https://pubmed.ncbi.nlm.nih.gov/27702629

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Treatment of adult and pediatric high-grade gliomas with Withaferin A: antitumor mechanisms and future perspectives

Autor: Regina M. Graham, Eduardo A. Veliz, Sumedh Subodh Shah, Megan M. Marlow, Michael E. Ivan

Publikováno v: Journal of natural medicines. 71(1)

Resistance mechanisms employed by high-grade gliomas allow them to successfully evade current standard treatment of chemotherapy and radiation treatment. Withaferin A (WA), utilized in Ayurvedic medicine for centuries, is attracting attention for its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928a58d17e7e52fc6e939671aa810cd7
https://pubmed.ncbi.nlm.nih.gov/27372348

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