Discovery of an indole-substituted furanone with tubulin polymerization inhibition activity

Autor: Deborah O. Kwansare, Kaitlynn A. Sockett, Namita D. Neerukonda, Patricia Mowery, Erin T. Pelkey, Megan M. Lafferty, Nathan R. Webster, Marissa A. McFadden, Kelsey Pierce, Brianna Hurysz, Roslyn R. Patel, Nathanyal J. Truax, Madison M. Filkorn

Publikováno v: Bioorganicmedicinal chemistry letters. 41

Analogs of diarylpyrrolinone lead compound 1 were prepared and tested for anti-proliferative activity in U-937 cancer cells. Alterations of 1 focused on modifying the two nitrogen atoms: a) the pyrrolinone nitrogen atom was substituted with a propyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc9b6c5e1071b7a94a6b5b2fdfb1e9e
https://pubmed.ncbi.nlm.nih.gov/33775833

Synthesis of Benzo[a]carbazoles and an Indolo[2,3-a]carbazole from 3-Aryltetramic Acids

Autor: Deborah O. Kwansare, Maeve H. Kean, Fernando Banales Mejia, Erin T. Pelkey, Megan M. Lafferty, Nathanyal J. Truax

Publikováno v: The Journal of Organic Chemistry. 81:6808-6815

A simple and flexible approach to 3-pyrrolin-2-one fused carbazoles is disclosed. The key step involves the BF3-mediated electrophilic substitution of indoles with N-alkyl-substituted 3-aryltetramic acids, which provides access to indole-substituted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4e24e6f84df878c9919479b112b471
https://doi.org/10.1021/acs.joc.6b01072

"This has reinvigorated me": perceived impacts of an innovation training program on employee experience and innovation support.

Autor: Newell S; Center to Improve Veteran Involvement in Care (CIVIC), VA Portland Health Care System, Portland, Oregon, USA., Cutrona SL; Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.; Center for Healthcare Organization and Implementation Research (CHOIR), VA Bedford Healthcare System, Bedford, Massachusetts, USA., Lafferty M; Portland VA Research Foundation, Portland, Oregon, USA., Lerner B; VA San Francisco Health Care System, San Francisco, California, USA., Vashi AA; Center for Innovation to Implementation (Ci2i), VA Palo Alto Health Care System, Menlo Park, California, USA.; Department of Emergency Medicine, University of California San Francisco, San Francisco, California, USA.; Department of Emergency Medicine (Affiliated), Stanford University, Palo Alto, California, USA., Jackson GL; Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), VA Durham Health Care System, Durham, North Carolina, USA.; Peter O'Donnell Jr. School of Public Health, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Amrhein A; Innovators Network, VHA Innovation Ecosystem, US Department of Veterans Affairs, Washington, District of Columbia, USA., Cole B; Innovators Network, VHA Innovation Ecosystem, US Department of Veterans Affairs, Washington, District of Columbia, USA., Tuepker A; Center to Improve Veteran Involvement in Care (CIVIC), VA Portland Health Care System, Portland, Oregon, USA.; Department of Family Medicine and Division of General Internal Medicine and Geriatrics, Oregon Health and Science University, Portland, Oregon, USA.

Publikováno v: Journal of health organization and management [J Health Organ Manag] 2024 Oct 10; Vol. ahead-of-print (ahead-of-print). Date of Electronic Publication: 2024 Oct 10.

Prevalence and Correlates of VA-Purchased Community Care Use Among Post-9/11-Era Veterans With Traumatic Brain Injury.

Autor: Govier DJ; Center to Improve Veteran Involvement in Care, VA Portland Healthcare System, Portland, Oregon (Drs Govier, Lafferty, Mulcahy, O'Neil, and Carlson and Ms Gilbert); Oregon Health & Science University-Portland State University School of Public Health, Portland, Oregon (Drs Govier, Mulcahy, and Carlson); Center of Innovation for Complex Chronic Care, Edward Hines Jr VA Hospital, Hines, Illinois (Ms Jacob); Center for Healthcare Organization and Implementation Research, VA Boston Healthcare System, Boston, Massachusetts (Drs Pogoda and Zogas); Boston University School of Public Health, Boston, Massachusetts (Dr Pogoda); Boston University Chobanian & Avedisian School of Medicine Section of General Internal Medicine, Boston, Massachusetts (Dr Zogas); Oregon Health & Science University, Portland, Oregon (Dr O'Neil); and Informatics, Decision-Enhancement and Analytic Sciences Center of Innovation, Salt Lake City, Utah, and University of Utah, Salt Lake City, Utah (Dr Pugh)., Gilbert TA, Jacob RL, Lafferty M, Mulcahy A, Pogoda TK, Zogas A, O'Neil ME, Pugh MJ, Carlson KF

Publikováno v: The Journal of head trauma rehabilitation [J Head Trauma Rehabil] 2024 May-Jun 01; Vol. 39 (3), pp. 207-217. Date of Electronic Publication: 2023 Aug 14.

VA-Delivered or VA-Purchased Care: Important Factors for Veterans Navigating Care Decisions.

Autor: Lafferty M; Center to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, OR, USA. megan.lafferty@va.gov., Govier DJ; Center to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, OR, USA.; Oregon Health & Science University - Portland State University School of Public Health, Portland, OR, USA., Golden SE; Center to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, OR, USA., Disher NG; Center to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, OR, USA., Hynes DM; Center to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, OR, USA.; Health Management and Policy Program, College of Public Health and Human Sciences and Center for Quantitative Life Sciences, Oregon State University, Corvallis, OR, USA.; School of Nursing, Oregon Health & Science University, Portland, OR, USA., Slatore CG; Center to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, OR, USA.; Division of Pulmonary & Critical Care Medicine, Department of Medicine, Oregon Health & Science University, Portland, OR, USA.

Publikováno v: Journal of general internal medicine [J Gen Intern Med] 2023 May; Vol. 38 (7), pp. 1647-1654. Date of Electronic Publication: 2023 Mar 15.