Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Megan M. Harper"'
Autor:
Megan M Harper, Miranda Lin, Michael J Cavnar, Prakash K Pandalai, Reema A Patel, Mei Gao, Joseph Kim
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0270832 (2022)
Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease with limited therapeutic options. Immune checkpoint inhibitors (ICIs) have demonstrated promising results in many cancers, but thus far have yi
Externí odkaz:
https://doaj.org/article/64643cfe7ca7498b8ffacd84c3bc4c2d
Autor:
Reema A Patel, MD, Miranda Lin, BS, Megan M Harper, MS, MD, Sandra J Beck, MD, Charles S Dietrich, MD, Jill M Kolesar, PhD, MS, Susanne M Arnold, MD, John Hahn, MD, Prakash K Pandalai, MD, Shadi A Qasem, MD, Joseph Kim, MD
Publikováno v:
Current Problems in Cancer: Case Reports, Vol 4, Iss , Pp 100074- (2021)
Malignant mesothelioma is a rare disease that typically occurs in older patients with prolonged exposure to asbestos. The majority of mesothelioma occurs in the pleura. Less frequently, patients will develop peritoneal mesothelioma without pleural in
Externí odkaz:
https://doaj.org/article/765f258bf3fb4fd58c0b9c2af74bb75d
Autor:
Minsig Choi, Megan M. Harper, Prakash K. Pandalai, Sherif R. Z. Abdel-Misih, Reema A. Patel, Carleton S. Ellis, Ellen Reusch, Jeri Reynolds, Caterina Vacchi-Suzzi, Jinha M. Park, Georgios V. Georgakis, Joseph Kim
Publikováno v:
Annals of Surgical Oncology. 30:804-813
Autor:
Gao, Hannah G. McDonald, Megan M. Harper, Kristen Hill, Anqi Gao, Angelica L. Solomon, Charles J. Bailey, Miranda Lin, Mautin Barry-Hundeyin, Michael J. Cavnar, Samuel H. Mardini, Prakash J. Pandalai, Reema A. Patel, Jill M. Kolesar, Justin A. Rueckert, Lawrence Hookey, Mark Ropeleski, Shaila J. Merchant, Joseph Kim, Mei
Publikováno v:
Cancers; Volume 15; Issue 11; Pages: 3036
Gastric adenocarcinoma (GAd) is the third leading cause of cancer-related deaths worldwide. Most patients require perioperative chemotherapy, yet methods to accurately predict responses to therapy are lacking. Thus, patients may be unnecessarily expo
Autor:
Hannah G. McDonald, Emily B. Cassim, Megan M. Harper, Erin E. Burke, Emily F. Marcinkowski, Michael J. Cavnar, Prakash K. Pandalai, Joseph Kim
Publikováno v:
Surgical oncology clinics of North America. 32(1)
Investigator-initiated trials (IITs) are designed by principal investigators who identify important, unaddressed clinical gaps and opportunities to answer these questions through clinical trials. Surgical oncologists are poised to lead IITs due to th
Autor:
Minsig, Choi, Megan M, Harper, Prakash K, Pandalai, Sherif R Z, Abdel-Misih, Reema A, Patel, Carleton S, Ellis, Ellen, Reusch, Jeri, Reynolds, Caterina, Vacchi-Suzzi, Jinha M, Park, Georgios V, Georgakis, Joseph, Kim
Publikováno v:
Annals of Surgical Oncology. 30:814-815
Autor:
Megan M. Harper, Miranda Lin, Shadi A. Qasem, Reema A. Patel, Michael J. Cavnar, Prakash K. Pandalai, Mei Gao, Joseph Kim
Publikováno v:
Cancers; Volume 14; Issue 13; Pages: 3051
We recently demonstrated that immune checkpoint PD-1 was endogenously expressed in pancreatic ductal adenocarcinoma (PDAC) cells. Our data indicated that PD-1 proteins are not exclusive to immune cells and have unrecognized signal transduction cascad
Publikováno v:
Journal of Clinical Medicine. 11:2840
Peritoneal carcinomatosis (PC) is a poor prognostic factor for all malignancies. This extent of metastatic disease progression remains difficult to treat with systemic therapies due to poor peritoneal vascularization resulting in limited drug deliver
Autor:
Mei Gao, Charles J. Bailey, Megan M. Harper, Michael J. Cavnar, Prakash Pandalai, Shadi A. Qasem, Joseph Kim
Publikováno v:
Cancer Research. 82:A029-A029
Background: Pancreatic ductal adenocarcinoma (PDAC) is highly drug resistant with no change in therapeutic approach for the last decade. The PDAC tumor microenvironment (TME) is highly desmoplastic and associated with altered treatment response. Our
Autor:
Miranda Lin, Joseph Kim, Michael J. Cavnar, Samuel H. Mardini, Prakash K. Pandalai, Shadi Qasem, Moamen Gabr, Reema A. Patel, Megan M. Harper, Mei Gao
Publikováno v:
Journal of the American College of Surgeons. 232(4)
Background Organoids are excellent 3-dimensional in vitro models of gastrointestinal cancers. However, patient-derived organoids (PDOs) remain inconsistent and unreliable for rapid actionable drug sensitivity testing due to size variation and limited