Výsledky vyhledávání - "Megan M. Spence"

Investigating the Order Parameters of Saturated Lipid Molecules under Various Curvature Conditions on Spherical Supported Lipid Bilayers

Autor: Lauren E. Marbella, Bocheng Yin, Megan M. Spence

Publikováno v: The Journal of Physical Chemistry B. 119:4194-4202

The conformations and motions of lipid molecules under different membrane curvatures have important implications for transmembrane protein function, binding events, and overall membrane organization. This work reports on the local order parameters of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df97a3d3e523840095ca7d91f5ea212
https://doi.org/10.1021/jp510322t

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Functionalized xenon as a biosensor

Autor: Shao Q. Yao, David E. Wemmer, Ivan E. Dimitrov, Megan M. Spence, Feng Tian, E. Janette Ruiz, Seth M. Rubin, Alexander Pines, Peter G. Schultz

Publikováno v: Proceedings of the National Academy of Sciences. 98:10654-10657

The detection of biological molecules and their interactions is a significant component of modern biomedical research. In current biosensor technologies, simultaneous detection is limited to a small number of analytes by the spectral overlap of their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d7eb5e9be979e8a0636266f056f45e
https://doi.org/10.1073/pnas.191368398

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Characterization of the Effects of Nonspecific Xenon–Protein Interactions on 129Xe Chemical Shifts in Aqueous Solution: Further Development of Xenon as a Biomolecular Probe

Autor: Megan M. Spence, Seth M. Rubin, David E. Wemmer, Alexander Pines

Publikováno v: Journal of Magnetic Resonance. 152:79-86

The sensitivity of 129 Xe chemical shifts to weak nonspecific xenon‐protein interactions has suggested the use of xenon to probe biomolecular structure and interactions. The realization of this potential necessitates a further understanding of how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b7c95cc162db4a4b1031407c2f3e42
https://doi.org/10.1006/jmre.2001.2389

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Development of a functionalized Xenon biosensor

Autor: Nicolas Winssinger, Seth M. Rubin, E. Janette Ruiz, David E. Wemmer, Megan M. Spence, Thomas J. Lowery, Alexander Pines, Peter G. Schultz

Publikováno v: Spence, Megan M.; Ruiz, E. Janette; Rubin, Seth M.; Lowery, Thomas J.; Winssinger, Nicolas; Schultz, Peter G.; et al.(2004). Development of a functionalized Xenon biosensor. Lawrence Berkeley National Laboratory. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/4ws7365n
Journal of the American Chemical Society, Vol. 126, No 46 (2004) pp. 15287-15294

NMR-based biosensors that utilize laser-polarized xenon offer potential advantages beyond current sensing technologies. These advantages include the capacity to simultaneously detect multiple analytes, the applicability to in vivo spectroscopy and im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79ef955d1d756ef9c57816fd633cac5
http://www.escholarship.org/uc/item/4ws7365n

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Applications of laser-polarized 129Xe to biomolecular assays

Autor: Seth M. Rubin, Peter G. Schultz, E. Janette Ruiz, Alexander Pines, Nicolas Winssinger, Megan M. Spence, Thomas J. Lowery, David E. Wemmer

Publikováno v: Magnetic Resonance Imaging, Vol. 21, No 10 (2003) pp. 1235-1239

The chemical shift sensitivity and significant signal enhancement afforded by laser-polarized 129Xe have motivated the application of 129Xe NMR to biological imaging and spectroscopy. Recent research done by our group has used laser-polarized 129Xe i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3f9a9f0fd71870b4331a3dec3d4878
https://pubmed.ncbi.nlm.nih.gov/14725931

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Amplification of Xenon NMR and MRI by remote detection

Autor: Sunil Saxena, Juliette A. Seeley, Megan M. Spence, Adam J. Moulé, Alexander Pines, Songi Han, Kimberly L. Pierce

Publikováno v: Moule, Adam J.; Spence, Megan M.; Han, Song-I.; Seeley, Juliette A.; Pierce, Kimberly L.; Saxena, Sunil; et al.(2003). Amplification of Xenon NMR and MRI by remote detection. Lawrence Berkeley National Laboratory. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/3wr0k64c

A technique is proposed in which an NMR spectrum or MRI is encoded and stored as spin polarization and is then moved to a different physical location to be detected. Remote detection allows the separate optimization of the encoding and detection step

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca15ac8e25c0b0a6272f6664e97d3c3e
http://www.escholarship.org/uc/item/3wr0k64c

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Evidence of nonspecific surface interactions between laser-polarized xenon and myoglobin in solution

Autor: Megan M. Spence, David E. Wemmer, Seth M. Rubin, Boyd M. Goodson, Alexander Pines

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 97(17)

The high sensitivity of the magnetic resonance properties of xenon to its local chemical environment and the large 129 Xe NMR signals attainable through optical pumping have motivated the use of xenon as a probe of macromolecular structure and dynami

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https://pubmed.ncbi.nlm.nih.gov/10931956

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Dynamics of Bicelle Model Membrane Promote Domain Formation

Autor: Hyo Soon Cho, Megan M. Spence

Publikováno v: Biophysical Journal. 98:219a

We have created a magnetically-aligned bicelle model membrane system (containing POPC, DMPC, and cholesterol) that laterally separates to form lipid domains. Lipid domains have been observed in a number of ternary systems (cholesterol, saturated lipi

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https://doi.org/10.1016/j.bpj.2009.12.1180

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