Výsledky vyhledávání - "Megan M Y Hong"

Inducing mismatch repair deficiency sensitizes immune-cold neuroblastoma to anti-CTLA4 and generates broad anti-tumor immune memory

Autor: Mikal El-Hajjar, Lara Gerhardt, Megan M Y Hong, Mithunah Krishnamoorthy, Rene Figueredo, Xiufen Zheng, James Koropatnick, Saman Maleki Vareki

Publikováno v: Molecular Therapy. 31:535-551

Immune checkpoint blockade can induce potent and durable responses in patients with highly immunogenic mismatch repair-deficient tumors; however, these drugs are ineffective against immune-cold neuroblastoma tumors. To establish a role for a T cell-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6be47af0ce3e39a6867edc567c153a
https://doi.org/10.1016/j.ymthe.2022.08.025

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IL-12 and IL-27 Promote CD39 Expression on CD8(+) T Cells and Differentially Regulate the CD39(+)CD8(+) T Cell Phenotype

Autor: Lara Gerhardt, Megan M. Y. Hong, Yeganeh Yousefi, Rene Figueredo, Saman Maleki Vareki

Publikováno v: J Immunol

Tumor-specific CD8+ T cells are critical components of antitumor immunity; however, factors that modulate their phenotype and function have not been completely elucidated. Cytokines IL-12 and IL-27 have recognized roles in promoting CD8+ T cells’ e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0b318f116ee3adde3077bc08370f6f
https://europepmc.org/articles/PMC10152038/

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