Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Megan M Weivoda"'
Autor:
Ming Xu, Allyson K Palmer, Husheng Ding, Megan M Weivoda, Tamar Pirtskhalava, Thomas A White, Anna Sepe, Kurt O Johnson, Michael B Stout, Nino Giorgadze, Michael D Jensen, Nathan K LeBrasseur, Tamar Tchkonia, James L Kirkland
Publikováno v:
eLife, Vol 4 (2015)
Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy. Here we show that primary human senescent fat progenitors secrete activin A and directly inhi
Externí odkaz:
https://doaj.org/article/ec852c46c83c4207854436df1e2e57e8
Autor:
Madison L. Doolittle, Brittany A. Eckhardt, Stephanie J. Vos, Sarah Grain, Jennifer L. Rowsey, Ming Ruan, Dominik Saul, Joshua N. Farr, Megan M. Weivoda, Sundeep Khosla, David G. Monroe
Publikováno v:
JBMR Plus, Vol 7, Iss 10, Pp n/a-n/a (2023)
ABSTRACT Estrogen regulates bone mass in women and men, but the underlying cellular mechanisms of estrogen action on bone remain unclear. Although both estrogen receptor (ER)α and ERβ are expressed in bone cells, ERα is the dominant receptor for s
Externí odkaz:
https://doaj.org/article/fce9a970aa3344afb432ff2b7082076c
Autor:
Rachelle W. Johnson, Megan M. Weivoda
Publikováno v:
JBMR Plus, Vol 5, Iss 10, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/903feb2cdbae4416be191e51d293716c
Autor:
Megan M. Weivoda, Chee Kian Chew, David G. Monroe, Joshua N. Farr, Elizabeth J. Atkinson, Jennifer R. Geske, Brittany Eckhardt, Brianne Thicke, Ming Ruan, Amanda J. Tweed, Louise K. McCready, Robert A. Rizza, Aleksey Matveyenko, Moustapha Kassem, Thomas Levin Andersen, Adrian Vella, Matthew T. Drake, Bart L. Clarke, Merry Jo Oursler, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy s
Externí odkaz:
https://doaj.org/article/801d47b97fd94e109d4d6b51b08d8de3
Autor:
Sam W. Z. Olechnowicz, Megan M. Weivoda, Seint T. Lwin, Szi K. Leung, Sarah Gooding, Guido Nador, Muhammed Kassim Javaid, Karthik Ramasamy, Srinivasa R. Rao, James R. Edwards, Claire M. Edwards
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Interactions between multiple myeloma (MM) and bone marrow (BM) are well documented to support tumour growth, yet the cellular mechanisms underlying pain in MM are poorly understood. We have used in vivo murine models of MM to show significa
Externí odkaz:
https://doaj.org/article/d8afcd0e1a894dd9a3e3bba9c52aefc9
Autor:
Megan M Weivoda, Elizabeth W Bradley
Publikováno v:
Journal of Bone and Mineral Research. 38:359-369
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8b7658b6172d76ca9da3e1b5b0d7e30
https://doi.org/10.1002/jbmr.4773
https://doi.org/10.1002/jbmr.4773
Publikováno v:
Semin Cell Dev Biol
Bone remodeling consists of resorption by osteoclasts (OCs) and formation by osteoblasts (OBs). Precise coordination of these activities is required for the resorbed bone to be replaced with an equal amount of new bone in order to maintain skeletal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe967fe396450a5103699bcc9edfe13
https://europepmc.org/articles/PMC8840962/
https://europepmc.org/articles/PMC8840962/
Autor:
Brittany A Negley, McKenzie M Fulcer, Jennifer L Onken, David G. Monroe, Daniel G. Fraser, Joshua N. Farr, Brianne S Thicke, Andre J. Van Wijnen, Megan M. Weivoda, Ruben Aquino-Martinez, Sundeep Khosla
Publikováno v:
Journal of Bone and Mineral Research. 34:135-144
Developing novel approaches to treat skeletal disorders requires an understanding of how critical molecular factors regulate osteoblast differentiation and bone remodeling. We have reported that (1) retinoic acid receptor-related orphan receptor beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c9332b10e22cbe5d2f1a09ad392b04
https://doi.org/10.1002/jbmr.3586
https://doi.org/10.1002/jbmr.3586
Autor:
Bart O. Williams, Alan K. Howe, Merry Jo Oursler, Larry Pederson, Ming Ruan, Christine M Hachfeld, Rachel A Davey, Megan M. Weivoda, Yasuhiro Kobayashi, Sundeep Khosla, Jennifer J. Westendorf, Jeffrey D Zajac
Publikováno v:
Journal of Bone and Mineral Research. 34:1546-1548
Although there has been extensive characterization of the Wnt signaling pathway in the osteoblast lineage, the effects of Wnt proteins on the osteoclast lineage are less well studied. We found that osteoclast lineage cells express canonical Wnt recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df26116b7ec428ea047d420f3c16a4a4
https://doi.org/10.1002/jbmr.3740
https://doi.org/10.1002/jbmr.3740
Autor:
Ming Ruan, Joshua N. Farr, Douglas Forrest, Brianne S Thicke, Megan M. Weivoda, Hong Liu, Kristy M. Nicks, John R. Hawse, Jennifer L Onken, Daniel G. Fraser, Sundeep Khosla, David G. Monroe, Brittany A Negley
Publikováno v:
Journal of Bone and Mineral Research. 33:720-731
There is a clinical need to identify new molecular targets for the treatment of osteoporosis, particularly those that simultaneously inhibit bone resorption while stimulating bone formation. We have previously shown in overexpression studies that ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8419fd767db37b8aa47fc82d9a0a5d
https://doi.org/10.1002/jbmr.3351
https://doi.org/10.1002/jbmr.3351