Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Megan M Shuey"'
Autor:
Megan M Shuey, Frederic T Billings, Shouzou Wei, Ginger L Milne, Hui Nian, Chang Yu, Nancy J Brown
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0175292 (2017)
Twenty to thirty percent of patients undergoing cardiac surgery develop acute kidney injury (AKI). In mice, inhibition of soluble epoxide hydrolase (sEH) attenuates renal injury following ischemia-reperfusion. We tested the hypothesis that functional
Externí odkaz:
https://doaj.org/article/89f5e6d017f94ee787bf194b3ec3094c
Autor:
Jeewoo Kim, Ariel Williams, Hannah Noh, Megan M. Shuey, Todd L. Edwards, Digna R. Velez Edwards, Jacklyn N. Hellwege
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 128-129 (2024)
OBJECTIVES/GOALS: Uterine fibroids are benign tumors of the uterus with a high disease prevalence and burden, yet there are few multi-ancestry genetic studies. This is the largest and most diverse fibroid GWAS to-date. Our goal is to identify novel g
Externí odkaz:
https://doaj.org/article/d875c36e29194fe6a46c0f0328562f8b
Autor:
Nicole D. Armstrong, Vinodh Srinivasasainagendra, Farah Ammous, Themistocles L. Assimes, Amber L. Beitelshees, Jennifer Brody, Brian E. Cade, Yii-Der Ida Chen, Han Chen, Paul S. de Vries, James S. Floyd, Nora Franceschini, Xiuqing Guo, Jacklyn N. Hellwege, John S. House, Chii-Min Hwu, Sharon L. R. Kardia, Ethan M. Lange, Leslie A. Lange, Caitrin W. McDonough, May E. Montasser, Jeffrey R. O’Connell, Megan M. Shuey, Xiao Sun, Rikki M. Tanner, Zhe Wang, Wei Zhao, April P. Carson, Todd L. Edwards, Tanika N. Kelly, Eimear E. Kenny, Charles Kooperberg, Ruth J. F. Loos, Alanna C. Morrison, Alison Motsinger-Reif, Bruce M. Psaty, Dabeeru C. Rao, Susan Redline, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Albert V. Smith, Marguerite R. Irvin, Donna K. Arnett
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Apparent treatment-resistant hypertension (aTRH) is characterized by the use of four or more antihypertensive (AHT) classes to achieve blood pressure (BP) control. In the current study, we conducted single-variant and gene-based analyse
Externí odkaz:
https://doaj.org/article/7b206fd782484f169fb7415ed4c3d533
Autor:
Mohammad Shahbazi, Xindi Zhang, Paul C. Dinh, Victoria A. Sanchez, Matthew R. Trendowski, Megan M. Shuey, Tessa Nguyen, Regeneron Genetics Center, Darren R. Feldman, David J. Vaughn, Chunkit Fung, Christian Kollmannsberger, Neil E. Martin, Lawrence H. Einhorn, Nancy J. Cox, Robert D. Frisina, Lois B. Travis, Mary Eileen Dolan
Publikováno v:
Cancer Medicine, Vol 12, Iss 3, Pp 2999-3012 (2023)
Abstract Purpose Deficits in speech understanding constitute one of the most severe consequences of hearing loss. Here we investigate the clinical and genetic risk factors for symmetric deterioration of speech recognition thresholds (SRT) among cance
Externí odkaz:
https://doaj.org/article/aedaa37449a4452f9310279b835a3e66
Autor:
Megan M. Shuey, Kyung Min Lee, Jacob Keaton, Nikhil K. Khankari, Joseph H. Breeyear, Venexia M. Walker, Donald R. Miller, Kent R. Heberer, Peter D. Reaven, Shoa L. Clarke, Jennifer Lee, Julie A. Lynch, Marijana Vujkovic, Todd L. Edwards
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104674- (2023)
Summary: Background: The identification of new uses for existing drug therapies has the potential to identify treatments for comorbid conditions that have the added benefit of glycemic control while also providing a rapid, low-cost approach to drug (
Externí odkaz:
https://doaj.org/article/0a32e0fd304d4bea90a5c225732f57ca
Autor:
Xindi Zhang, Matthew R. Trendowski, Emma Wilkinson, Mohammad Shahbazi, Paul C. Dinh, Megan M. Shuey, Regeneron Genetics Center, Darren R. Feldman, Robert J. Hamilton, David J. Vaughn, Chunkit Fung, Christian Kollmannsberger, Robert Huddart, Neil E. Martin, Victoria A. Sanchez, Robert D. Frisina, Lawrence H. Einhorn, Nancy J. Cox, Lois B. Travis, M. Eileen Dolan
Publikováno v:
Cancer Medicine, Vol 11, Iss 14, Pp 2801-2816 (2022)
Abstract Purpose Cisplatin is a critical component of first‐line chemotherapy for several cancers, but causes peripheral sensory neuropathy, hearing loss, and tinnitus. We aimed to identify comorbidities for cisplatin‐induced neurotoxicities amon
Externí odkaz:
https://doaj.org/article/44f25d0b9c9c44fea27f757e2ecf0dda
Autor:
Megan M. Shuey, Shi Huang, Rebecca T. Levinson, Eric Farber‐Eger, Katherine N. Cahill, Joshua A. Beckman, John R. Koethe, Heidi J. Silver, Kevin D. Niswender, Nancy J. Cox, Frank E. Harrell Jr., Quinn S. Wells
Publikováno v:
Obesity Science & Practice, Vol 8, Iss 1, Pp 124-130 (2022)
Abstract Objective Body mass index (BMI) is the most commonly used predictor of weight‐related comorbidities and outcomes. However, the presumed relationship between height and weight intrinsic to BMI may introduce bias with respect to prediction o
Externí odkaz:
https://doaj.org/article/c9dcc97893e74c4389f00826c3db4abb
Autor:
Victoria A. Sanchez, Megan M. Shuey, Paul C. Dinh, Patrick O. Monahan, Sophie D. Fosså, Howard D. Sesso, M. Eileen Dolan, Lawrence H. Einhorn, David J. Vaughn, Neil E. Martin, Darren R. Feldman, Kurt Kroenke, Chunkit Fung, Robert D. Frisina, Lois B. Travis
Publikováno v:
Journal of Clinical Oncology. 41:2211-2226
PURPOSE Cisplatin is widely used and highly ototoxic, but patient-reported functional impairment because of cisplatin-related hearing loss (HL) and tinnitus has not been comprehensively evaluated. PATIENTS AND METHODS Testicular cancer survivors (TCS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ea69c90cea501d0b83f250baa1ac3f1
https://doi.org/10.1200/jco.22.01456
https://doi.org/10.1200/jco.22.01456
Autor:
Ambra Pozzi, Scott M. Williams, F. Peter Guengerich, John R. Falck, Jorge H. Capdevila, Megan M. Shuey, James M. Luther, Roy Zent, Shouzuo Wei, Shaojun Mei, Manuel Chiusa, Mahesha H. Gangadhariah, Lindsay N. Sausville
This file contains the primer sequence of CYP2C9* variants (Supplementary Table S1); the SNPs genotyped in the BioVU NSCLC study (Supplementary Table S2); quality control measures of SNPs in the BioVU NSCLC study (Supplementary Table S3); clinical an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308f7412116c1324a40a6f5c93f46538
https://doi.org/10.1158/0008-5472.22426270.v1
https://doi.org/10.1158/0008-5472.22426270.v1
Autor:
Ambra Pozzi, Scott M. Williams, F. Peter Guengerich, John R. Falck, Jorge H. Capdevila, Megan M. Shuey, James M. Luther, Roy Zent, Shouzuo Wei, Shaojun Mei, Manuel Chiusa, Mahesha H. Gangadhariah, Lindsay N. Sausville
Increased expression of cytochrome P450 CYP2C9, together with elevated levels of its products epoxyeicosatrienoic acids (EET), is associated with aggressiveness in cancer. Cytochrome P450 variants CYP2C9*2 and CYP2C9*3 encode proteins with reduced en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff77c3335eea0c969f51ecdd1f48097
https://doi.org/10.1158/0008-5472.c.6512281
https://doi.org/10.1158/0008-5472.c.6512281