Relations Between Bone Quantity, Microarchitecture, and Collagen Cross‐links on Mechanics Following In Vivo Irradiation in Mice

Autor: Megan M Pendleton, Shannon R Emerzian, Saghi Sadoughi, Alfred Li, Jennifer W Liu, Simon Y Tang, Grace D O'Connell, Jean D Sibonga, Joshua S Alwood, Tony M Keaveny

Publikováno v: JBMR Plus, Vol 5, Iss 11, Pp n/a-n/a (2021)

ABSTRACT Humans are exposed to ionizing radiation via spaceflight or cancer radiotherapy, and exposure from radiotherapy is known to increase risk of skeletal fractures. Although irradiation can reduce trabecular bone mass, alter trabecular microarch

Externí odkaz: https://doaj.org/article/58ae334e547645b9a909a70b799bcf1b

High-precision method for cyclic loading of small-animal vertebrae to assess bone quality

Autor: Megan M. Pendleton, Saghi Sadoughi, Alfred Li, Grace D. O'Connell, Joshua S. Alwood, Tony M. Keaveny

Publikováno v: Bone Reports, Vol 9, Iss , Pp 165-172 (2018)

One potentially important bone quality characteristic is the response of bone to cyclic (repetitive) mechanical loading. In small animals, such as in rats and mice, cyclic loading experiments are particularly challenging to perform in a precise manne

Externí odkaz: https://doaj.org/article/b66c33c2b7044ff69cb56fc395e72527

Effects of ex vivo ionizing radiation on collagen structure and whole-bone mechanical properties of mouse vertebrae

Autor: Jennifer W. Liu, Simon Y. Tang, Shannon R. Emerzian, Megan M. Pendleton, Grace D. O'Connell, Joshua S. Alwood, Tony M. Keaveny

Publikováno v: Bone

Bone can become brittle when exposed to ionizing radiation across a wide range of clinically relevant doses that span from radiotherapy (accumulative 50 Gy) to sterilization (~35,000 Gy). While irradiation-induced embrittlement has been attributed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4005913f7a8967c408ba8523f8032de6
https://pubmed.ncbi.nlm.nih.gov/31445224

Dietary countermeasure mitigates simulated spaceflight-induced osteopenia in mice.

Autor: Steczina S; Blue Marble Space Institute of Science, Seattle, WA, 98154, USA.; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, 94035, USA., Tahimic CGT; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, 94035, USA.; KBR, Moffett Field, California, USA., Pendleton M; Department of Mechanical Engineering, University of California, Berkeley, Berkeley, CA, 94720, USA., M'Saad O; Space Life Sciences Training Program, NASA Ames Research Center, Moffett Field, CA, 94035, USA., Lowe M; Blue Marble Space Institute of Science, Seattle, WA, 98154, USA.; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, 94035, USA., Alwood JS; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, 94035, USA., Halloran BP; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA., Globus RK; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, 94035, USA., Schreurs AS; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, 94035, USA. ann-sofie.schreurs@nasa.gov.; Universities Space Research Association, Moffett Field, CA, USA. ann-sofie.schreurs@nasa.gov.

Publikováno v: Scientific reports [Sci Rep] 2020 Apr 16; Vol. 10 (1), pp. 6484. Date of Electronic Publication: 2020 Apr 16.